Results 41 to 50 of about 1,805,611 (181)

Endothelial cell-derived SSAO can increase MLC20 phosphorylation in VSMCs

Open Life Sciences, 2021
Vascular hyporesponsiveness in the shock decompensation period is an important factor leading to death. Myosin light chain 20 (MLC20) is the main effector protein that regulates vascular reactivity.
Zhang Yuxing, Zhang Xiliang, Cao Zhen, Huang Yun, Zheng Yuexin, Yang Xiaodong   +5 more
doaj   +1 more source

Versatile synthesis of novel tetrahydroquinolines as potentially active semicarbazide-sensitive amine oxidase (SSAO) inhibitors via tert-amino effect

ARKIVOC, 2016
Several aminomethyl tetrahydroquinoline derivatives were synthesized in a facile three-ste procedure, in order to develop a semicarbazide-sensitive amine oxidase (SSAO) inhibitor library as proved by in vitro test on rat aorta microsomal fraction.
Ruth Deme, Michele Schlich, Zoltán Mucsi, Gellért Karvaly, Gergő Tóth, Péter Mátyus   +5 more
doaj   +2 more sources

Copper-dependent amino oxidase 3 governs selection of metabolic fuels in adipocytes. [PDF]

PLoS Biology, 2018
Copper (Cu) has emerged as an important modifier of body lipid metabolism. However, how Cu contributes to the physiology of fat cells remains largely unknown.
Haojun Yang, Martina Ralle, Michael J Wolfgang, Neha Dhawan, Jason L Burkhead, Susana Rodriguez, Jack H Kaplan, G William Wong, Norman Haughey, Svetlana Lutsenko   +9 more
doaj   +1 more source

Effects of Chemical Structures Interacting with Amine Oxidases on Glucose, Lipid and Hydrogen Peroxide Handling by Human Adipocytes

Molecules, 2022
Benzylamine is a natural molecule present in food and edible plants, capable of activating hexose uptake and inhibiting lipolysis in human fat cells.
Christian Carpéné, Pénélope Viana, Zsuzsa Iffiú-Soltesz, Pál Tapolcsányi, Anna Ágota Földi, Péter Mátyus, Petra Dunkel   +6 more
doaj   +1 more source

Oral Administration of Semicarbazide Limits Weight Gain together with Inhibition of Fat Deposition and of Primary Amine Oxidase Activity in Adipose Tissue

Journal of Obesity, 2011
An enzyme hitherto named semicarbazide-sensitive amine oxidase (SSAO), involved in the oxidation of primary amines, is abundantly expressed in adipocytes.
Josep Mercader, Zsuzsa Iffiú-Soltész, Sandy Bour, Christian Carpéné   +3 more
doaj   +1 more source

Amine oxidase copper-containing 3 (AOC3) inhibition: a potential novel target for the management of diabetic retinopathy

International Journal of Retina and Vitreous, 2021
Background Diabetic retinopathy (DR), a microvascular complication of diabetes, is the leading cause of visual impairment in people aged 20–65 years and can go undetected until vision is irreversibly lost.
David S. Boyer, Joerg F. Rippmann, Michael S. Ehrlich, Remko A. Bakker, Victor Chong, Quan Dong Nguyen   +5 more
doaj   +1 more source

Increased atherosclerotic plaque in AOC3 knock-out in ApoE−/− mice and characterization of AOC3 in atherosclerotic human coronary arteries

Frontiers in Cardiovascular Medicine, 2022
IntroductionAmine oxidase copper containing 3 (AOC3) displays adhesion between leukocytes and endothelial cells and enzymatic functions. Given its controversial role in atherogenesis, we proposed to investigate the involvement of AOC3 in the formation of
Anna Filip, Soraya Taleb, Rümeyza Bascetin, Mohammad Jahangiri, Matthieu Bardin, Cindy Lerognon, Bruno Fève, Patrick Lacolley, Sirpa Jalkanen, Nathalie Mercier   +9 more
doaj   +1 more source

Inhibition of semicarbazide-sensitive amine oxidase (SSAO) by various antidepressants drugs in monkey platelets [PDF]

, 2016
I examined whether two or more distinct amine oxidases exist in monkey platelets. Km values of amine oxidase in monkey platelets were determined with benzylamine as substrate from the Lineweaver-Burk double reciprocal plots.
OBATA, Toshio
core   +1 more source

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue

Medicines, 2020
Background: Methylxanthines including caffeine and theobromine are widely consumed compounds and were recently shown to interact with bovine copper-containing amine oxidase.
Wiem Haj Ahmed, Cécile Peiro, Jessica Fontaine, Barry J. Ryan, Gemma K. Kinsella, Jeff O’Sullivan, Jean-Louis Grolleau, Gary T.M. Henehan, Christian Carpéné   +8 more
doaj   +1 more source

Interstitial renal fibrosis due to multiple cisplatin treatments is ameliorated by semicarbazide-sensitive amine oxidase inhibition [PDF]

, 2016
Elucidation of acute kidney diseases and disorders (AKD), including acute kidney injury (AKI), is important to prevent their progression to chronic kidney disease. Current animal AKI models are often too severe for use in evaluating human AKI. Therefore,
Negishi, Kousuke, Sugaya, Takeshi, Katagiri, Daisuke, Hamasaki, Yoshifumi, Nangaku, Masaomi, Doi, Kent, Noiri, Eisei   +6 more
core   +1 more source