Results 61 to 70 of about 2,006 (201)

An integrated approach with new strategies for QSAR models and lead optimization [PDF]

, 2017
Compound testing set for huAChE collected from Guo et al.
Hui-Hui Hsu, Jinn-Moon Yang, Li-Jen Chang, Yen-Chao Hsu   +3 more
core   +2 more sources

Plasma Copper Level Correlates With Body Mass Index–Adjusted Body Weight Loss Grades and Total Fat Mass in Male Patients With Recurrent or Metastatic Head and Neck and Nasopharyngeal Cancers

European Journal of Cancer Care, Volume 2025, Issue 1, 2025.
Purpose There is a lack of comprehensive analysis on the associations between malnutrition, body composition, and clinical, anthropometric, biochemical, nutrition‐inflammation markers, mineral and trace element levels, cytokine concentrations, and antioxidant activity in patients with cancer.
Chun-Feng Wu, Pei-Hung Chang, Hang Huong Ling, Yi-Ping Pan, Yu-Ching Lin, Wen-Chi Chou, Chia-Lin Peng, Zih-Syuan Chen, Simon Hsia, Kun-Yun Yeh, Tarcilia Silva   +10 more
wiley   +1 more source

Phenelzine: An old drug that may hold clues to the development of new neuroprotective agents

Psychiatry and Clinical Psychopharmacology, 2021
The monoamine oxidase (MAO)-inhibiting antidepressant phenelzine (PLZ) is also used in the treatment of anxiety disorders such as panic disorder and social anxiety disorder and has been shown to have neuroprotective actions in an animal model of ...
Erin M. MacKenzie, Mee-Sook Song, Serdar Dursun, Sara Tomlinson, Kathryn G. Todd, Glen B. Baker   +5 more
doaj  

Procarbazine and antidepressants: a retrospective review of the risk of serotonin toxicity [PDF]

, 2013
Background Procarbazine is an anticancer agent that also inhibits monoamine oxidase, an enzyme responsible for the metabolism of various catecholamines, including serotonin.
Baker, Nicole M., Bostwick, Jolene R., Carpenter, Julia, Kraft, Shawna L.   +3 more
core   +1 more source

Molecular Cloning and Characterization of Rat Semicarbazide-Sensitive Amine Oxidase

Biological and Pharmaceutical Bulletin, 2005
Semicarbazide-sensitive amine oxidase (SSAO) (EC 1.4.3.6) is widely distributed in nature and catalyzes the oxidative deamination of primary amines. Although SSAO full-length cDNA sequences have been reported for some mammalian species, only a partial 5'-terminal sequence has been confirmed in the rat.
Yoshinori, Ochiai, Kunio, Itoh, Eiichi, Sakurai, Yorihisa, Tanaka   +3 more
openaire   +3 more sources

Endothelial Dysfunctions in Blood–Brain Barrier Breakdown in Alzheimer's Disease: From Mechanisms to Potential Therapies

CNS Neuroscience &Therapeutics, Volume 30, Issue 11, November 2024.
Blood–brain barrier (BBB) works as a crucial structure separating central nervous system (CNS) and circulating system. The highly organized endothelial junctions and transporters strictly restricts substance exchange across BBB to maintain the homeostasis of CNS.
Qian Yue, Xinyue Leng, Ningqing Xie, Zaijun Zhang, Deguang Yang, Maggie Pui Man Hoi   +5 more
wiley   +1 more source

Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeutics [PDF]

, 2016
The reactive dicarbonyl metabolite methylglyoxal (MG) is the precursor of the major quantitative advanced glycation endproducts (AGEs) in physiological systems - argininederived hydroimidazolones and deoxyguanosine-derived imidazopurinones.
Rabbani, Naila, Thornalley, Paul J., Xue, Mingzhan   +2 more
core   +1 more source

Properties of a Semicarbazide-Sensitive Amine Oxidase in Human Umbilical Artery

Journal of Pharmacy and Pharmacology, 1988
Abstract The metabolism of some aromatic amines by amine oxidase activities in human umbilical artery homogenates has been studied. The inhibitory effects of clorgyline showed that 5-hydroxytryptamine (5-HT) and tryptamine, 1 mM, were predominantly substrates for monoamine oxidase (MAO) type A, whereas MAO-A and B were both involved in ...
E, Precious, G A, Lyles
openaire   +2 more sources

Proof-of-Concept for the Analgesic Effect and Thermoregulatory Safety of Orally Administered Multi-Target Compound SZV 1287 in Mice: A Novel Drug Candidate for Neuropathic Pain

Biomedicines, 2021
SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth, Nikolett Szentes, Valéria Tékus, Maja Payrits, Éva Szőke, Emőke Oláh, András Garami, Eszter Fliszár-Nyúl, Miklós Poór, Cecília Sár, Tamás Kálai, Szilárd Pál, Krisztina Percze, Éva Nagyné Scholz, Tamás Mészáros, Blanka Tóth, Péter Mátyus, Zsuzsanna Helyes   +17 more
doaj   +1 more source

Advanced glycoxidation and lipoxidation end products (AGEs and ALEs): an overview of their mechanisms of formation [PDF]

, 2013
Advanced lipoxidation end products (ALEs) and advanced glycation end products (AGEs) have a pathogenetic role in the development and progression of different oxidative-based diseases including diabetes, atherosclerosis, and neurological disorders.
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core   +1 more source