Results 61 to 70 of about 1,805,611 (181)
Pharmaceuticals, 2020 Treatment with several antipsychotic drugs exhibits a tendency to induce weight gain and diabetic complications. The proposed mechanisms by which the atypical antipsychotic drug olanzapine increases body weight include central dysregulations leading to ...
Christian Carpéné +8 more
doaj +1 more source
The ROS-generating and antioxidant systems in the liver of rats treated with prednisolone and vitamin D(3) [PDF]
The Ukrainian Biochemical Journal, 2014 The mechanisms of glucocorticoid-induced disturbances of liver function is currently not fully clarified. Vitamin D3 was previously shown to play an important role in the regulation of impaired oxidative metabolism and detoxification function of the ...
I. O. Shymanskyy +5 more
doaj +1 more source
Biomedicines, 2021 SZV 1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime) is a novel multi-target candidate under preclinical development for neuropathic pain. It inhibits amine oxidase copper containing 3, transient receptor potential ankyrin 1 and vanilloid 1 (TRPV1 ...
Ádám István Horváth +17 more
doaj +1 more source
Oxime Derivatives: A Valid Pharmacophore in Medicinal Chemistry
ChemistrySelect, Volume 9, Issue 27, July 18, 2024.Oximes are considered as versatile pharmacophores in discovery new class of medicinally active agents. The incorporation of hydroxylamine‐containing moieties to the carbonyl compounds can generate variety oximes. The current review focused on 49 reports, describing about various activities, including antimicrobial, anticancer, anti‐inflammatory ...
Namitha Chandran +13 more
wiley +1 more source
Aldolase B knockdown prevents high glucose-induced methylglyoxal overproduction and cellular dysfunction in endothelial cells. [PDF]
PLoS ONE, 2012 We used cultured endothelial cells as a model to examine whether up-regulation of aldolase B and enhanced methylglyoxal (MG) formation play an important role in high glucose-induced overproduction of advanced glycosylation endproducts (AGEs), oxidative ...
Jianghai Liu +5 more
doaj +1 more source
Molecular Cloning and Characterization of Rat Semicarbazide-Sensitive Amine Oxidase
Biological and Pharmaceutical Bulletin, 2005 Semicarbazide-sensitive amine oxidase (SSAO) (EC 1.4.3.6) is widely distributed in nature and catalyzes the oxidative deamination of primary amines. Although SSAO full-length cDNA sequences have been reported for some mammalian species, only a partial 5'-terminal sequence has been confirmed in the rat.
Ochiai, Yoshinori +3 more
openaire +3 more sources
Semicarbazide-sensitive Amine Oxidase Activity in White Adipose Tissue of the Insulin-deficient Rat
, 1995 We have investigated whether the effects in white adipose tissue due to insulin deficiency might also be related to an alteration of histamine levels which are regulated by semicarbazide-sensitive amine oxidase.
G Ignesti +4 more
core +1 more source
, 2000 Aims Experimental evidence has suggested that semicarbazide-sensitive amine oxidase is involved in vascular endothelial damage and in the process of atherosclerosis, through the formation of reactive aldehydes, hydrogen peroxide and ammonia from ...
De Kam, PJ +3 more
core +1 more source
Resveratrol Anti-Obesity Effects: Rapid Inhibition of Adipocyte Glucose Utilization
Antioxidants, 2019 Studies in animal models of diabetes and obesity have shown that resveratrol mitigates complications of metabolic diseases, beyond those resulting from oxidative stress.
Christian Carpéné +7 more
doaj +1 more source
Inhibition of chickpea seedling copper amine oxidases by tetraethylenepentamine [PDF]
Copper amine oxidases are important enzymes, which contribute to the regulation of monoand polyamine levels. Each monomer contains one Cu(II) ion and 2,4,5-trihydroxyphenylalanine (TPQ) as cofactors.
اسدی, اسداله +2 more
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