Correlation between total nitrite/nitrate concentrations and monoamine oxidase (types A and B) and semicarbazide-sensitive amine oxidase enzymatic activities in human mesenteric arteries from non-diabetic and type 2 diabetic patients [PDF]
Brazilian Journal of Medical and Biological Research, 2012 The aim of this study was to determine the correlation between total nitrite/nitrate concentrations (NOx) and the kinetic parameters of monoamine oxidase enzymes (MAO-A and MAO-B) and semicarbazide-sensitive amine oxidase (SSAO) in human mesenteric ...
S.F. Nunes +4 more
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Inactivation of Semicarbazide-Sensitive Amine Oxidase Stabilizes the Established Atherosclerotic Lesions via Inducing the Phenotypic Switch of Smooth Muscle Cells. [PDF]
PLoS ONE, 2016 Given that the elevated serum semicarbazide-sensitive amine oxidase (SSAO) activity is associated with the severity of carotid atherosclerosis in clinic, the current study aims to investigate whether SSAO inactivation by semicarbazide is beneficial for ...
Ya Peng +6 more
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The role of vascular adhesion protein‐1 in diabetes and diabetic complications
Journal of Diabetes InvestigationVascular adhesion protein‐1 (VAP‐1) plays a dual role with its adhesive and enzymatic properties, facilitating leukocyte migration to sites of inflammation and catalyzing the breakdown of primary amines into harmful by‐products, which are linked to ...
I‐Weng Yen, Hung‐Yuan Li
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The role of “semicarbazide-sensitive amine oxidase” in the arterial wall
Artery Research, 2009 “Semicarbazide-sensitive amine oxidase” (SSAO) metabolizes primary amines into aldehydes, hydrogen peroxide and ammonia and is largely expressed in adipocytes, lymphatic endothelial cells and vascular smooth muscle cells (VSMCs). In vitro SSAO expression
N. Mercier
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Properties of a Semicarbazide-Sensitive Amine Oxidase in Human Umbilical Artery
Journal of Pharmacy and Pharmacology, 1988 Abstract The metabolism of some aromatic amines by amine oxidase activities in human umbilical artery homogenates has been studied. The inhibitory effects of clorgyline showed that 5-hydroxytryptamine (5-HT) and tryptamine, 1 mM, were predominantly substrates for monoamine oxidase (MAO) type A, whereas MAO-A and B were both involved in ...
E, Precious, G A, Lyles
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Association of <italic>AOC3</italic> Expression in Visceral Adipose Tissue and Circulating Soluble Vascular Adhesion Protein-1 with Arterial Stiffness Assessed by Cardio-Ankle Vascular Index in Japanese Patients with Severe Obesity [PDF]
Obesity FactsIntroduction: Soluble vascular adhesion protein-1 (sVAP-1), which is identical to semicarbazide-sensitive amine oxidase (SSAO), contributes to oxidative stress and vascular dysfunction.
Osamu Horikawa +9 more
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Paper de l'Amino-Oxidasa Sensible a Semicarbazida, SSAO/VAP-1, del teixit adipós en la diabetis "mellitus" [PDF]
, 2003 [cat] L'SSAO/VAP-1 és una proteïna amb una dualitat de funció; d'una banda, presenta activitat enzimàtica amino-oxidasa i, de l'altra, presenta propietats d'adhesió que la impliquen en l'extravasació de limfòcits en processos inflamatoris.
Abella Martí, Anna
core +7 more sources
Oxidative deamination of aliphatic amines by rat aorta semicarbazide-sensitive amine oxidase
Journal of Pharmacy and Pharmacology, 1990 AbstractRat aorta semicarbazide-sensitive amine oxidase (SSAO) exhibits very high affinity in the deamination of an homologous series of aliphatic amines of 1 to 18 straight chain carbon atoms. The Km value decreases substantially as the chain length of these amines increases. The Vmax values are higher for the short chain amines.
Peter H Yu
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Semicarbazide diminishes the signs of bleomycin-induced pulmonary fibrosis in rats [PDF]
The Ukrainian Biochemical Journal, 2021 The pathogenesis of pulmonary fibrosis (PF) is accompanied by extracellular matrix (ECM) deposition, oxidative stress, and inflammation progression, as well as hyperactivation of amine oxidases (AOs), which contribute to disease manifestation.
O. O. Hudkova +5 more
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Red-light photobiomodulation improves cognition and neuropsychiatric symptoms in post-stroke cognitive impairment: a randomized trial [PDF]
Frontiers in NeurologyIntroductionAcute stroke patients often develop post-stroke cognitive impairment (PSCI) and dysthymic disorders. Formaldehyde (FA) induces cognitive decline and depression; while red light (RL) at 630 nm can degrade FA by activating FA-dehydrogenase (FDH)
Xuerong Huang +20 more
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