Semicarbazide-sensitive amine oxidase inhibition ameliorates albuminuria and glomerulosclerosis but does not improve tubulointerstitial fibrosis in diabetic nephropathy. [PDF]
PLoS One, 2020 Wong MY +8 more
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Beneficial Impact of Semicarbazide-Sensitive Amine Oxidase Inhibition on the Potential Cytotoxicity of Creatine Supplementation in Type 2 Diabetes Mellitus. [PDF]
Molecules, 2020 Papukashvili D, Rcheulishvili N, Deng Y.
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Semicarbazide-sensitive amine oxidase (SSAO): from cell to circulation.
Medical science monitor : international medical journal of experimental and clinical research, 2005 Semicarbazide-sensitive amine oxidase (SSAO) is a multi-functional enzyme widely present in nature. It converts primary amines into their corresponding aldehydes, while generating H(2)O(2) and NH(3). In mammals, SSAO circulates in plasma, while a membrane-bound form (often referred to as vascular adhesion protein-1, VAP-1) is found in many tissues and ...
Boomsma, F +4 more
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Oxidative deamination of aliphatic amines by rat aorta semicarbazide-sensitive amine oxidase
Journal of Pharmacy and Pharmacology, 1990 AbstractRat aorta semicarbazide-sensitive amine oxidase (SSAO) exhibits very high affinity in the deamination of an homologous series of aliphatic amines of 1 to 18 straight chain carbon atoms. The Km value decreases substantially as the chain length of these amines increases. The Vmax values are higher for the short chain amines.
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Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification. [PDF]
Oxid Med Cell Longev, 2020 Mercier N +7 more
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The role of “semicarbazide-sensitive amine oxidase” in the arterial wall
Artery Research, 2009 “Semicarbazide-sensitive amine oxidase” (SSAO) metabolizes primary amines into aldehydes, hydrogen peroxide and ammonia and is largely expressed in adipocytes, lymphatic endothelial cells and vascular smooth muscle cells (VSMCs). In vitro SSAO expression and activity increase during VSMC differentiation and SSAO participates in glucose uptake but its ...
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Studies of Monoamine Oxidase and Semicarbazide-Sensitive Amine Oxidase
Japanese Journal of Pharmacology, 1986 Yuichiro ARAL +2 more
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Effects of semicarbazide-sensitive amine oxidase inhibitors on morphology of aorta and kidney in diabetic rats. [PDF]
BMC Endocr Disord, 2019 Li C, Wang Z, Li X, Chen J.
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Inhibition of Semicarbazide-sensitive Amine Oxidase Reduces Atherosclerosis in Cholesterol-fed New Zealand White Rabbits. [PDF]
Sci Rep, 2018 Wang SH +10 more
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Antiglycation, radical scavenging, and semicarbazide-sensitive amine oxidase inhibitory activities of acetohydroxamic acid in vitro. [PDF]
Drug Des Devel Ther, 2017 Liu YH, Lu YL, Liu DZ, Hou WC.
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