Results 41 to 50 of about 6,501 (215)

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

open access: yesPharmaceuticals, 2022
The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity.
Ayesha Naseer   +7 more
doaj   +1 more source

Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators

open access: yesMolecules, 2022
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu   +7 more
doaj   +1 more source

ANTAGONISM OF THE SPINAL ACTION OF DIAZEPAM BY SEMICARBAZIDE [PDF]

open access: yesBritish Journal of Pharmacology, 1974
In spinal unanaesthetized cats, pretreatment with semicarbazide (200 mg/kg) 2–4.5 h prior to the administration of diazepam (1–4 mg/kg) completely blocked the enhancement of the segmental dorsal root reflex by the latter compound. Pyridoxine hydrochloride (200 mg/kg), given 3.5 h after semicarbazide, restored the spinal effect of diazepam administered ...
N R, Banna, S J, Jabbur, N E, Saadé
openaire   +2 more sources

Effects of the food contaminant semicarbazide on testicular morphology of juvenile Wistar rats

open access: yesArquivo Brasileiro de Medicina Veterinária e Zootecnia, 2012
O objectivo do presente trabalho foi avaliar os efeitos da semicarbazida na morfologia testicular de ratos Wistar jovens. Os animais foram tratados durante 30 dias com hidrocloreto de semicarbazida incorporado na dieta, nas concentrações de 0, 3 e 6g/kg.
A Ramos   +3 more
doaj   +1 more source

Subcellular Location of Semicarbazide-sensitive Amine Oxidase in Rat Aorta

open access: yes, 1980
With tyramine as substrate, a considerable part of the amine oxidase activity of rat aorta was inhibited by 0.1 mM semicarbazide. The residual activity was little affected by 1 mM semiicarbazide.
Godfraind, Theophile   +2 more
core   +1 more source

Semicarbazide Functionalized Flax Fibers for Effective Adsorption of Cr(VI) from Wastewater Samples

open access: yes, 2021
Semicarbazid modified flax fiber (SC.MFF) was successfully synthesized for the removal of Cr(IV) from different wastewater samples. Preparation of the SC.MFF material occurred in two main steps, the first step is the oxidation of the flax fibers by ...
Mohamed, Hashem   +3 more
core   +1 more source

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

open access: yesMedicines, 2019
Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper ...
Christian Carpéné   +3 more
doaj   +1 more source

Integrative proteomics and metabolomics reveal the stress response of semicarbazide in the sea cucumber Apostichopus japonicus

open access: yesFrontiers in Marine Science, 2022
Semicarbazide (SMC), also known as carbamoyl hydrazide, is a key intermediate for the organic synthesis of drugs, pesticides, and a panoply of other applications.
Lixin Lu   +8 more
doaj   +1 more source

Advances in organic UV filters for sunscreens over the past decade

open access: yesPhotochemistry and Photobiology, EarlyView.
Highlighted organic UV filter frameworks that have been described for sunscreens over the past decade divided into three groups: derivatives of or inspired by approved organic UV filters, natural product‐based compounds, and miscellaneous. Abstract Ultraviolet (UV) radiation is a major environmental factor in photoaging, erythema, and skin cancer ...
Gabriela Zanella Marcon   +4 more
wiley   +1 more source

Azasulfurylpeptide Modulation of CD36-Mediated Inflammation Without Effect on Neovascularization

open access: yesBiomedicines, 2018
Modulation of the cluster of differentiation-36 receptor (CD36) has proven promising for dampening pro-inflammatory macrophage signaling. For example, azapeptides (e.g., 1 and 2) bind CD36 selectively with high affinity, mitigate Toll-like receptor (TLR)
Stéphane Turcotte   +8 more
doaj   +1 more source

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