Monoamine Oxidase and Cholinesterase Inhibition Profiles of Semicarbazone and Thiosemicarbazone Derivatives. [PDF]
Chem BiodiversThiosemicarbazones generally show higher MAO‐B inhibitory potential than their corresponding semicarbazones, and particularly T6 is the most potent, which contains R = H and X = S in its Tail Unit, with an IC50 value of 6.45 µM with SI of 3.6. ABSTRACT Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for ...
Bindra S +11 more
europepmc +2 more sources
Ribosomal Synthesis of Topologically Defined Thioisoindole-Bridged Bicyclic Peptides. [PDF]
Angew Chem Int Ed EnglA flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Zhang Y, Vinogradov AA, Sun Y, Suga H.
europepmc +3 more sources
Development of a Partial Proteolysis Targeting Chimera Library Based on Achiral Cereblon E3 Ligase Ligands and its Application for Bruton's Tyrosine Kinase Degraders. [PDF]
ChemMedChemA partial proteolysis targeting chimera (PROTAC) library bearing achiral phenyl dihydrouracil cereblon ligands is prepared. It is then applied to the rapid development of a full PROTAC library targeting Bruton's tyrosine kinase, which can be directly used for screening.
Almodóvar-Rivera CM +5 more
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Semicarbazide diminishes the signs of bleomycin-induced pulmonary fibrosis in rats [PDF]
The Ukrainian Biochemical Journal, 2021 The pathogenesis of pulmonary fibrosis (PF) is accompanied by extracellular matrix (ECM) deposition, oxidative stress, and inflammation progression, as well as hyperactivation of amine oxidases (AOs), which contribute to disease manifestation.
O. O. Hudkova +5 more
doaj +1 more source
Untargeted Metabolomics Analysis of Semicarbazide Metabolism in Procambarus clarkii under Nitrofurazone Stress [PDF]
Shipin Kexue, 2023 In this study, in order to investigate the metabolic pathway of semicarbazide, a metabolite of nitrofurazone, in crustacean aquatic products, the accumulation of nitrofurazone and its metabolites in Procambarus clarkii was evaluated at different time ...
CHEN Xiaxia, ZHANG Yi, XIANG Desheng, HU Shi, CHEN Xuechang, ZHANG Xiaojun
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The Effect of Semicarbazide on the Thyroid Gland of Juvenile Male Albino Rat and Possibility of Recovery: Histological and Immunohistochemical Study [PDF]
The Egyptian Journal of Histology, 2022 Background: Semicarbazide (SEM) is a byproduct of azodicarbonamide widely employed in the industry of plastic gaskets used in sealing glass jars, especially baby foods jars.Aim of the Study: To determine the effects and possibility of recovery of ...
noha Elswaidy, Heba Sharaf eldin
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Harmful Effect of Semicarbazide on the Ovary of Adult Albino Rats and the Possible Reversibility of the Induced Lesions (Biochemical and Histological Study) [PDF]
The Egyptian Journal of Histology, 2023 Introduction: Semicarbazide (SEM) has gained concerns about its existence, excessive exposure and possible hazards to the human health. Infants and children are at more risk of exposure to SEM because their high intake of food put in glass jars as jams ...
Zeinab Alazouny +2 more
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Acta Crystallographica Section E: Crystallographic Communications, 2022 The title polymer, [Cu(SO4)(CH5N3O)2]n, has been synthesized from aqueous solutions of CuSO4 and semicarbazide. In the crystal structure, the CuII atoms are chelated by two neutral semicarbazide molecules through the oxygen atom and a nitrogen atom of ...
Galiya Tadjieva +4 more
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Kinetics study of hydrazodicarbonamide synthesis reaction [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2013 In this study, the kinetics of hydrazodicarbonamide (HDCA) synthesis reaction was investigated. Hydrazodicarbonamide is prepared by reaction of urea and hydrazine in acidic medium. Synthesis of HDCA from urea and hydrazine is a two steps reaction.
Bakeri Gh., Rahimnejad M.
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Synthesis of 1,6-bis(semicarbazide)hexanes and 1,6-bis(1,2,4-triazol-5-one)hexanes and their antiproliferative and antimicrobial activity [PDF]
Journal of the Serbian Chemical Society, 2012 A series of 1,6-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-on-4- yl)hexanes (3a-g) were synthesized by the cyclization reaction of 1,6-bis(1- substituted-semicarbazide-4-yl)hexanes (2a-g) in alkaline medium.
Pitucha M. +3 more
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