Results 11 to 20 of about 5,509 (177)

Monoamine Oxidase and Cholinesterase Inhibition Profiles of Semicarbazone and Thiosemicarbazone Derivatives. [PDF]

Chem Biodivers
Thiosemicarbazones generally show higher MAO‐B inhibitory potential than their corresponding semicarbazones, and particularly T6 is the most potent, which contains R = H and X = S in its Tail Unit, with an IC50 value of 6.45 µM with SI of 3.6. ABSTRACT Twenty semicarbazone and thiosemicarbazone derivatives (T1–T20) were synthesized and evaluated for ...
Bindra S, Jeong WK, Kabier M, Kumar S, Sudevan ST, Vishwakarma HC, Parambi DGT, Maliyakkal N, Kumar S, Pappachen LK, Kim H, Mathew B.   +11 more
europepmc   +2 more sources

Screening of Chemical Residues and Antimicrobial Resistance in Dehydrated Chicken Feet Intended as Dog Treats: A Pilot Study. [PDF]

Vet Med Int
The pet population is steadily increasing worldwide, and treats, which account for approximately 15% of the pet food market, are the fastest‐growing segment of the pet food industry. However, the widespread use of antimicrobials in poultry farms may pose a direct risk to pets’ health, leading to the emergence of antimicrobial resistance.
Marini C, Lipani F, Sabia C, Nicotra M, Iseppi R, Biscontini G, Cerquetella M, Meschiari M, Gregorio GD, Alagawany M, Tardugno R, Corbo F, Cerbo AD.   +12 more
europepmc   +2 more sources

Ribosomal Synthesis of Topologically Defined Thioisoindole-Bridged Bicyclic Peptides. [PDF]

Angew Chem Int Ed Engl
A flexible in vitro translation (FIT) system‐based strategy for ribosomal synthesis of thioisoindole‐bridged bicyclic (TiB) peptides is developed. The flexizyme substrate Ac‐Ala(NtBA)Sc‐CME is efficiently incorporated into FIT to generate ribosomal peptides bearing N‐terminal Ac‐Ala(NtBA)Sc as the cyclization handle, which after mild deprotection ...
Zhang Y, Vinogradov AA, Sun Y, Suga H.
europepmc   +3 more sources

Seventy-Day Toxicity Study in Juvenile Sprague-Dawley Rats with Semicarbazide (SEM) from Weaning to Sexual Maturity

Journal of Toxicology, 2022
The study was conducted to evaluate the toxicological effects, functional observation battery tests, and sexual maturity of semicarbazide oral gavage administration to juvenile Sprague-Dawley rats for 70 days at 0, 15, 30, and 60 mg/kg/day weaning to ...
Vijaykumar Malashetty, Raghunandan Deshpande, Somnathreddy Patil   +2 more
doaj   +1 more source

Kinetics study of hydrazodicarbonamide synthesis reaction [PDF]

Chemical Industry and Chemical Engineering Quarterly, 2013
In this study, the kinetics of hydrazodicarbonamide (HDCA) synthesis reaction was investigated. Hydrazodicarbonamide is prepared by reaction of urea and hydrazine in acidic medium. Synthesis of HDCA from urea and hydrazine is a two steps reaction.
Bakeri Gh., Rahimnejad M.
doaj   +1 more source

Synthesis of 1,6-bis(semicarbazide)hexanes and 1,6-bis(1,2,4-triazol-5-one)hexanes and their antiproliferative and antimicrobial activity [PDF]

Journal of the Serbian Chemical Society, 2012
A series of 1,6-bis(3-substituted-4,5-dihydro-1H-1,2,4-triazol-5-on-4- yl)hexanes (3a-g) were synthesized by the cyclization reaction of 1,6-bis(1- substituted-semicarbazide-4-yl)hexanes (2a-g) in alkaline medium.
Pitucha M., Rzymowska J., Olender A., Grzybowska-Szatkowska L.   +3 more
doaj   +1 more source

Effects of Acute and Chronic Exposure to Semicarbazide on the Sea Cucumber Apostichopus japonicus

Frontiers in Environmental Science, 2021
The effects of acute and chronic exposure to semicarbazide were carried out on the sea cucumber Apostichopus japonicus. A half-maximal lethal concentration of 3.72 g/L of semicarbazide hydrochloride (95% confidence interval 3.43–4.02 g/L) was deduced. At
Xiuhui Tian, Huanjun Li, Xiuzhen Zhang, Yingjiang Xu, Huawei Zhang, Dianfeng Han, Huan Liu, Bin Wang, Yanmei Cui, Huihui Liu, Quanli Zhou, Xianghong Gong   +11 more
doaj   +1 more source

A Mechanistic Study on the Non-genotoxic Carcinogenicity of the Food Contaminant Semicarbazide

SURE Journal: (Science Undergraduate Research Experience Journal), 2020
Semicarbazide was brought to the forefront of scientific discussions by the scientific community in the early 2000’s as the substance was discovered in several food products from both synthetic and natural sources.
Daniel P. Fitzpatrick
doaj   +1 more source

Study of the inhibitory effect of some thiourea compounds on the activity of enzyme purified polyamine oxidase from the blood of patients with type 1 diabetes [PDF]

مجلة التربية والعلم, 2013
The research included determination of  polyamine oxidase (PAO) activity in normal and diabeti patients type I females. It was found that the activity of  PAO in red blood cells (RBC) and plasma in  patients were significantly higher than that of normal ...
Nashwan Abbou, Khawla Al.Fleih, Eyad Hamid   +2 more
doaj   +1 more source

Toward functional integration of 3D-printed meniscal scaffolds: A materials-driven systematic review of preclinical evidence and translational framework. [PDF]

J Exp Orthop
Abstract Purpose Meniscal injuries are among the most common knee disorders and a major risk factor for osteoarthritis. Although meniscectomy provides short‐term symptom relief, it irreversibly alters joint biomechanics, underscoring the need for regenerative strategies.
Ferrero A, Anzillotti G, Conte P, Resta S, Micalizzi S, Cappelli C, Mansour N, Oliva P, Kon E, D'Arrigo D.   +9 more
europepmc   +2 more sources