Results 31 to 40 of about 7,328 (210)

Toward functional integration of 3D-printed meniscal scaffolds: A materials-driven systematic review of preclinical evidence and translational framework. [PDF]

J Exp Orthop
Abstract Purpose Meniscal injuries are among the most common knee disorders and a major risk factor for osteoarthritis. Although meniscectomy provides short‐term symptom relief, it irreversibly alters joint biomechanics, underscoring the need for regenerative strategies.
Ferrero A, Anzillotti G, Conte P, Resta S, Micalizzi S, Cappelli C, Mansour N, Oliva P, Kon E, D'Arrigo D.   +9 more
europepmc   +2 more sources

Amine oxidases as important agents of pathological processes of rhabdomyolysis in rats [PDF]

The Ukrainian Biochemical Journal, 2016
In this study we have tested an idea on the important role of amine oxidases (semicarbazide-sensitive amine oxidase, diamine oxidase, polyamine oxidase) as an additional source of oxidative/carbonyl stress under glycerol-induced rhabdomyolysis, since the
O. O. Gudkova, N. V. Latyshko, S. G. Shandrenko   +2 more
doaj   +1 more source

Exploring Novel Pyridine Carboxamide Derivatives as Urease Inhibitors: Synthesis, Molecular Docking, Kinetic Studies and ADME Profile

Pharmaceuticals, 2022
The rapid development of resistance by ureolytic bacteria which are involved in various life-threatening conditions such as gastric and duodenal cancer has induced the need to develop a new line of therapy which has anti-urease activity.
Ayesha Naseer, Faisal Abdulrhman Osra, Asia Naz Awan, Aqeel Imran, Abdul Hameed, Syed Adnan Ali Shah, Jamshed Iqbal, Zainul Amiruddin Zakaria   +7 more
doaj   +1 more source

Effects of the food contaminant semicarbazide on testicular morphology of juvenile Wistar rats

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2012
O objectivo do presente trabalho foi avaliar os efeitos da semicarbazida na morfologia testicular de ratos Wistar jovens. Os animais foram tratados durante 30 dias com hidrocloreto de semicarbazida incorporado na dieta, nas concentrações de 0, 3 e 6g/kg.
A Ramos, A. Pereira, A.S Cabrita, F. Capela e Silva   +3 more
doaj   +1 more source

Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators

Molecules, 2022
Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu, Jiangang Huang, Yin Cao, Zhaolin Zhang, Fengming He, Xianfu Lin, Qi Wu, Shengxian Zhao   +7 more
doaj   +1 more source

Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct

, 2016
Semicarbazide is a widespread food contaminant that is produced by multiple pathways. However, the toxicity of semicarbazide to human health remains unclear.
Wan Chan (1376217), Yinan Wang (478812), Tin-Yan Wong (1629214)   +2 more
core   +1 more source

The Enhanced Daily Excretion of Urinary Methylamine in Rats Treated with Semicarbazide or Hydralazine May Be Related to the Inhibition of Semicarbazide-sensitive Amine Oxidase Activities

, 1989
The effects of amine oxidase inhibitors upon the daily urinary excretion of monomethylamine (MMA), dimethylamine (DMA), trimethylamine (TMA) and ammonia in the rat have been examined.
S A Mcdougall, G A Lyles
core   +1 more source

The action of semicarbazide on the aggregation of the tropocollagen macromolecule [PDF]

Biochemical Journal, 1967
1. A difference in conformation was found between the collagen in solutions treated with semicarbazide hydrochloride and those treated with sodium chloride. This difference could be correlated with the difference in extent of aggregation between the fibrils precipitated from these solutions. 2.
S, Convy, C H, Wynn
openaire   +2 more sources

ANTAGONISM OF THE SPINAL ACTION OF DIAZEPAM BY SEMICARBAZIDE [PDF]

British Journal of Pharmacology, 1974
In spinal unanaesthetized cats, pretreatment with semicarbazide (200 mg/kg) 2–4.5 h prior to the administration of diazepam (1–4 mg/kg) completely blocked the enhancement of the segmental dorsal root reflex by the latter compound. Pyridoxine hydrochloride (200 mg/kg), given 3.5 h after semicarbazide, restored the spinal effect of diazepam administered ...
N R, Banna, S J, Jabbur, N E, Saadé
openaire   +2 more sources

Past, Present and Future Anti-Obesity Effects of Flavin-Containing and/or Copper-Containing Amine Oxidase Inhibitors

Medicines, 2019
Background: Two classes of amine oxidases are found in mammals: those with a flavin adenine dinucleotide as a cofactor, such as monoamine oxidases (MAO) and lysine-specific demethylases (LSD), and those with copper as a cofactor, including copper ...
Christian Carpéné, Nathalie Boulet, Alice Chaplin, Josep Mercader   +3 more
doaj   +1 more source