Results 51 to 60 of about 6,501 (215)

N‐Amidinyl‐Benzodiazaborines as Novel Boron‐Based Scaffolds: Synthesis and Application in Retromer Stabilization

Advanced Synthesis &Catalysis, Volume 368, Issue 11, 3 June 2026.
In this work, we successfully synthesized a library of novel N‐amidinyl‐benzodiazaborines, showing how these heteroaryl guanyl hydrazones are able to stabilize the retromer, a protein complex involved in the disposal of misfolded and aggregated proteins, whose malfunction is observed in multiple neurodegenerative diseases.
Alessandro Dimasi, Arianna Montoli, Michele Buonaguro, Leonardo Maiorana, Giovanni Macetti, Eleonora Colombo, Luca Muzio, Greta Donati, Daniele Passarella, Pierfausto Seneci, Valerio Fasano   +10 more
wiley   +1 more source

Quantitation of the DNA Adduct of Semicarbazide in Organs of Semicarbazide-Treated Rats by Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry: A Comparative Study with the RNA Adduct

, 2016
Semicarbazide is a widespread food contaminant that is produced by multiple pathways. However, the toxicity of semicarbazide to human health remains unclear.
Wan Chan (1376217), Yinan Wang (478812), Tin-Yan Wong (1629214)   +2 more
core   +1 more source

Toxicological Evaluation of the Undesirable Components in Processed Infant Foods Using Artificial Intelligence

Future Postharvest and Food, Volume 3, Issue 2, Page 185-205, June 2026.
The detection of toxins in baby food using artificial intelligence. ABSTRACT Infant foods and baby formulas are becoming increasingly popular across the globe owing to their ease of consumption and nutritional value specific to infants. Impurities may find their way into the food chain at any point from the acquisition of raw materials to final ...
Poornima Singh, Anurag Singh, Ashutosh Upadhyay, Navneet Kumar   +3 more
wiley   +1 more source

Synthesis of Steroidal Thiadiazoles from Steroidal Ketones

Molecules, 2005
Syntheses of steroidal heterocycles containing a five-membered N,S- heterocycle attached at the 6,7 positions of the B ring are reported. 5α-Cholestane-6-one (1), its 3β-acetoxy- (2) and 3β-chloro- (3) analogues reacted with semicarbazide and ...
M. Akhtar, M. Alam, M. Mushfiq
doaj   +1 more source

A molecular tuner: Substituent controlled π/π···hole induced selective colorimetric intramolecular push-pull fluoride sensor

Chemical Engineering Journal Advances, 2022
Controlling the anion selectivity of synthetic anion receptors towards a particular anion is challenging task for researcher. In the case of bipodal receptors this become trickier since anion can approach the recognition elements of receptors from any ...
Vanthana Jeyasingh, Kumaresan Murugesan, Sudha Lakshminarayanan, Narayanan Selvapalam, Geetha Dass, Lakshminarayanan Piramuthu   +5 more
doaj   +1 more source

Unveiling the Power of Deuterium in Drug Discovery: A Comprehensive Overview

MedComm, Volume 7, Issue 6, June 2026.
The role of deuterium replacement in drug discovery, its progress, opportunities, and challenges. ABSTRACT Deuterium, the heavy isotope of hydrogen, has unfolded as a cornerstone in modern drug discovery due to its potential to influence metabolic stability and pharmacokinetic behavior.
Mukta Lele, Ajit Manchare, Swapnali Parit, Amol D. Gholap, Krishna Jadhav, Navnath Hatvate, Keshav Raj Paudel, Satish Rojekar   +7 more
wiley   +1 more source

Temporal and spatial distribution of semicarbazide in western Laizhou Bay

, 2016
Semicarbazide (SEM), an industrial raw material and the marker residue of nitrofurazone as a veterinary drug, has become a new type of marine pollutant. A standard method (ultra-performance liquid chromatography-tandem mass spectrometry, UPLC-MS/MS) was ...
Liu, YH, Zhou, QL, Xia, CH (reprint author), Chinese Acad Sci, Yantai Inst Coastal Zone Res, Yantai 264003, Peoples R China., Xia, CH, Song, XK, Gong, XH, Wang, ZQ, Xia, CH (reprint author), Ludong Univ, Yantai 264025, Peoples R China. Email:article0535@163.com, Xu, YJ, Tian, XH   +9 more
core   +1 more source

Methylamine Activates Glucose Uptake in Human Adipocytes Without Overpassing Action of Insulin or Stimulating its Secretion in Pancreatic Islets

Medicines, 2019
Background: Methylamine, a natural soluble amine present in foods, is known to be a substrate of primary amine oxidase (PrAO) widely expressed in animal tissues.
Christian Carpéné, Pascale Mauriège, Nathalie Boulet, Simon Biron, Jean-Louis Grolleau, Maria José Garcia-Barrado, Mari Carmen Iglesias-Osma   +6 more
doaj   +1 more source

Methylxanthines Inhibit Primary Amine Oxidase and Monoamine Oxidase Activities of Human Adipose Tissue

Medicines, 2020
Background: Methylxanthines including caffeine and theobromine are widely consumed compounds and were recently shown to interact with bovine copper-containing amine oxidase.
Wiem Haj Ahmed, Cécile Peiro, Jessica Fontaine, Barry J. Ryan, Gemma K. Kinsella, Jeff O’Sullivan, Jean-Louis Grolleau, Gary T.M. Henehan, Christian Carpéné   +8 more
doaj   +1 more source

On‐Demand Chemically Degradable Hydrogels for Biological Applications

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
This review explores the mechanisms and kinetics of chemically induced on‐demand degradation in hydrogels designed for painless dressing removal and traceless dissolution across various biological applications. Covalent bond cleavage and noncovalent disruption triggers are compared, highlighting opportunities for load‐bearing scaffolds with faster ...
Xinyi Sheng, Justin Kim
wiley   +1 more source