Discovery of water-soluble semicarbazide-containing sulfonamide derivatives possessing favorable anti-glaucoma effect in vivo and drug-like properties [PDF]
Saudi Pharmaceutical JournalIn order to obtain topical and non-irritating anti-glaucoma drugs, novel semicarbazide-containing sulfonamide derivatives were designed and synthetized by sugar tail method in this study.
Yingxia Xie +3 more
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Molecular Engineering of Binder for Improving the Mechanical Properties and Recyclability of Energetic Composites [PDF]
Nanomaterials, 2023 Mechanical properties and reprocessing properties are of great significance to the serviceability and recyclability of energetic composites. However, the mechanical robustness of mechanical properties and dynamic adaptability related to reprocessing ...
Jing Yang +6 more
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New 4-(Morpholin-4-Yl)-3-Nitrobenzhydrazide Based Scaffold: Synthesis, Structural Insights, and Biological Evaluation [PDF]
MoleculesThe search for new antimicrobial agents is one of the major challenges in contemporary medicinal chemistry due to the global issue of increasing drug resistance.
Michał Janowski +8 more
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Anticancer Activity and Safety Profile of Novel 1-(4-Fluorophenoxyacetyl)-4-substituted Thio/Semicarbazide Derivatives [PDF]
MoleculesCompounds with thiosemicarbazide and semicarbazide scaffolds are among the most promising structures in medicinal chemistry due to the possibility of forming multiple hydrogen bonds.
Paweł Kozyra +7 more
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Synthesis and Biological Evaluation of 1-(2-(6-Methoxynaphthalen-2-yl)-6-methylnicotinoyl)-4-Substituted Semicarbazides/Thiosemicarbazides as Anti-Tumor Nur77 Modulators [PDF]
Molecules, 2022 Nur77 is an orphan nuclear receptor that participates in the occurrence and development of a variety of tumors. Many agonists of Nur77 have been reported to have significant anticancer effects.
Hongyu Hu +7 more
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PECULIARITIES OF ISOCYANATES INTERACTION WITH HYDRAZINE DERIVATIVES [PDF]
Тонкие химические технологии, 2018 The results of studies on chemical transformations of organic and organosilicon isocyanates in their interaction with hydrazine derivatives have been summarized in this review.
A. D. Kirilin +4 more
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Synthesis, Characterization, Anticancer, Antioxidant, and In Silico Evaluation of Semicarbazides and Thiosemicarbazides [PDF]
ACS OmegaAnam Shahzadi +8 more
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Ecotoxicology and Environmental Safety, 2023 Semicarbazide (SEM), the metabolite of antibiotic nitrofurazone, is often used as the biomarker to determine the use of nitrofurazone. Frequent false-positive events of SEM have brought great trouble to the aquatic industry in international trade.
Yi Zhang +5 more
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Progress on the Origin and Formation Mechanism of Semicarbazide in Crustacean Aquatic Products
Progress in Fishery Sciences, 2023 Nitrofurazone is a synthetic antimicrobial drug developed by the Eaton Institute in the United States in the 1950s. Nitrofurazone can play an inhibitory or bactericidal role by interfering with the glucose metabolism process and oxidase system in ...
Shengjun CHEN +7 more
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Molecules, 2015 This study addressed the design and syntheses of diverse ligands, which were then successfully treated with Ni (II) ion to afford a series of nickel complexes. α-Chloroformylarylhydrazine hydrochlorides 6 contain two different functional groups. One is
Mei-Hsiu Shih +3 more
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