Results 31 to 40 of about 2,335 (166)
Hypothalamic Astrocytes Exhibit Glycolytic Features Making Them Prone for Glucose Sensing
Glia, Volume 73, Issue 11, Page 2253-2272, November 2025.Main Points Hypothalamic astrocytes versus cortical astrocytes: are more glycolytic due to high Pkm2, Glut1 and Mct4 expression do not exhibit glutamate‐induced glycolysis detect glucose concentration variations via an AMPK sensor with altered lactate production.
Sarah Geller +11 more
wiley +1 more source
Synthesis and anticonvulsant activity of some 1-cyclohexylidine/ cycloheptylidine-4-substitued semicarbazide derivatives [PDF]
, 2020 Aryl semicarbazide derivatives are reported to possess anticonvulsant activity. On the other hand unsubstituted and small substituents (less than 3 carbon atom) containing cyclohexanones prevented both pentylenetetrazole and MES induced seizures ...
Gajbhiye, Asmita
core +1 more source
Batch Synthesis of Primaquine Diphosphate Anti‐Malarial Drug
Chemistry – A European Journal, Volume 31, Issue 59, October 22, 2025.According to the WHO, a child under the age of five dies every 2 minutes from malaria in Africa. It is therefore paramount that access and availability of anti‐malarial drugs must be improved. We report a process for the synthesis of Primaquine Diphosphate, where key intermediates were obtained in a much shorter reaction time compared to processes ...
Faith M. Akwi +2 more
wiley +1 more source
Preparation of substituted hydrazines [PDF]
, 1952 Thesis (M.A.)--Boston UniversityAlthough a large number of substituted hydrazines are known, the preparation of simple monoalkylhydrazines in a manner suitable for the large-scale economical synthesis has never been developed.
Briggs, Richard Maurice
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Synthesis of Novel Dihydropyridine‐Iminium Salts Containing a Selenazine Core
Asian Journal of Organic Chemistry, Volume 14, Issue 10, October 2025.An efficient method to develop novel dihydropyrido[3,2‐e][1,3]selenazines iminium salts. A comparative study of the key reagent selenourea towards thiourea and urea was carried out to assess the contribution of chalcogen to the pathway. DFT (density functional theory) calculations have predicted the optimized minimum energy structure for the hybrid ...
Reinier Lemos +6 more
wiley +1 more source
ChemistryEurope, Volume 3, Issue 5, September 18, 2025.A pH‐programmable site‐selective cysteine modification in peptides is reported using a triazine–thiol exchange, termed TriTEx. At acidic pH, internal cysteines are targeted while preserving N‐terminal sites; at neutral pH, N‐terminal cysteines are selectively modified via an irreversible S–N shift.
Katerina Gavriel +5 more
wiley +1 more source
Synthesis and anti-Aphid Aphis gossypii (Glover) activity of some new quinoline derivatives [PDF]
, 2010 A series of quinoline derivatives have been elaborated fromreaction of 2-(m- and p-acetylanilino)-quinolines 6a-b withaldehydes under Claisen-Schmidt conditions followed by cyclization with phenyl hydrazine and hydroxylamine.
El Kafafy, Abdel Kader +3 more
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Hazelnut: Explorations toward the Biocatalytic Synthesis of its Aroma Precursor
ChemBioChem, Volume 26, Issue 16, September 12, 2025.This article proposes a biosynthetic route for synthesizing filbertone, the principal flavor compound of hazelnut, through a multienzyme cascade. The pathway uses D‐amino acid oxidase, threonine deaminase, and a regioselective transketolase from Geobacillus stearothermophilus to produce a sustainable, natural hazelnut aroma precursor, addressing ...
Mireia Salvadó‐Pau +3 more
wiley +1 more source
Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]
, 2014 Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio +3 more
core +1 more source
Reviews in Aquaculture, Volume 17, Issue 4, September 2025.ABSTRACT Nitrofuran metabolites, including semicarbazide, pose significant risks to food safety, particularly in the aquatic industry. Bangladesh's shrimp industry faced major challenges due to nitrofuran contamination, leading to a voluntary export suspension to the European Union (EU).
S. M. Nazmul Alam
wiley +1 more source