Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures
Aging Cell, Volume 24, Issue 5, May 2025.Longevity humans have “a youthful erythrocyte function and metabolism” with a youth‐like oxygen release and anti‐oxidative capability to combat tissue hypoxia and improve healthspan. ABSTRACT Longevity individuals have lower susceptibility to chronic hypoxia, inflammation, oxidative stress, and aging‐related diseases.
Fang Yu +17 more
wiley +1 more source
Natural Sciences, Volume 5, Issue 1-2, April 2025.ABSTRACT Thiosemicarbazones (TSCs) and their metal complexes have been subjected to study over several decades. Their medicinal importance as anticancer, antioxidant, antimicrobial, and antidiabetic has been explored. Continual efforts have been made toward activity enhancement that can be achieved by making suitable structural alterations or by ...
Ekhlakh Veg +5 more
wiley +1 more source
Inflammaging and Immunosenescence in the Post‐COVID Era: Small Molecules, Big Challenges
ChemMedChem, Volume 20, Issue 6, March 15, 2025.The post‐COVID syndromes are strictly dependent from inflammaging and immunosenescence, for which the available treatments, particularly immunotherapy, have limited impact and safety issues. Alternative targets are under validation to disclose, besides anti‐inflammatory drugs, new small molecular entities able to counteract the imbalance of ...
Fabio Francavilla +6 more
wiley +1 more source
Applied Organometallic Chemistry, Volume 39, Issue 1, January 2025.A series of novel ferrocene derivatives, mimics of the clinical antibiotics, nifuroxazide and nitrofurazone, termed ferroxazides and ferrazones, respectively, were synthesized and evaluated for antitrypanosomatid activities. The ferroxazide 15 bearing dimethylamino moiety was identified in vitro as hit against Trypanosoma congolense strain but ...
Christina Kannigadu +4 more
wiley +1 more source
Electrochemical Synthesis of Heterocyclic Compounds. Part 21.1 Anodic Oxidation of 1-Arylmethylenesemicarbazides in Methanol [PDF]
, 1989 Anodic oxidation of 1-arylmethylenesemicarbazides (1-5) was performed in methanol-tetraethylammonium perchlorate electrolyte solution by constant-current electrolysis.
Ibro Tabaković +2 more
core +3 more sources
SYNTHESIS AND IN VITRO BIOLOGICAL EVALUATION OF 1-HEPTA-O-BENZOYL-β-D-MALTOSYL-4- BENZOTHIAZOLYL SEMICARBAZIDES [PDF]
, 2020 The present work aims to synthesize and screen the antifungal and antibacterial activities of a series of new 1-hepta-O-benzoyl-β-D-maltosyl-4-benzothiazolyl semicarbazides by the interaction of hepta-O-benzoyl-β-D-maltosyl isocyanate and substituted 2 ...
Benzothiazolyl Semicarbazides +4 more
core
Expansion of the Diazacyclobutene Motif for Antiparasitic Evaluation [PDF]
, 2023 Molecules containing N-heterocycles are prevalent in pharmaceutical settings. The ability to generate highly functionalized molecules containing N-heterocycles in very few synthetic operations is valuable for drug discovery. Our group has developed a two-
Miller, Brock Alexander
core +1 more source
Study of highly fluorinated heterocyclic polymers for cryogenic bladder applications Final report, 15 Oct. 1968 - 15 Mar. 1970 [PDF]
Highly fluorinated heterocyclic polymers for cryogenic bladder ...
Fitzgerald, W. P., Jr., Sanders, B. Y.
core +1 more source
A Review on Synthesis, Characterization Methods and Biological Activities of Semicarbazone, Thiosemi-Carbazone and Their Transition Metal Complexes [PDF]
, 2019 Semicarbazones and thiosemicarbazones are compounds obtained by condensation of Semicarbazides and thiosemicarbazide with suitable aldehydes or ketones.
Muleta, Fekadu
core +1 more source
Efficient synthesis of tri- and difluoroacetyl hydrazides as useful building blocks for non-symmetrically substituted, fluoroalkylated 1,3,4-oxadiazoles [PDF]
, 2016 A convenient and efficient approach to 2-arylamino-5-fluoroalkyl-1,3,4-oxadiazoles has been established via heterocyclization of tri- and difluoroacetylated thiosemicarbazides using dicyclohexylcarbodiimide.
Heimgartner, Heinz +3 more
core +1 more source