Results 31 to 40 of about 33,270 (306)

Testicular germ-cell tumours and penile squamous cell carcinoma: Appropriate management makes the difference [PDF]

, 2019
Germ-cell tumours (GCT) of the testis and penile squamous cell carcinoma (PeSCC) are a rare and a very rare uro-genital cancers, respectively. Both tumours are well defined entities in terms of management, where specific recommendations - in the form of ...
Almar E., Arveux P., Autelitano M., Baldi I., Bara S., Barchielli A., Benfatto L., Benhamou E., Bento M. J., Biasoni D., Bielska-Lasota M., Blaszczyk J., Bordoni A., Botta L., Bouchardy C., Bouvier A. -M., Bouvier V., Brewster D. H., Calleja N., Candela P., Capocaccia R., Carulla M., Catanzaro M. A., Clough-Gorr K., Colecchia M., Colonna M., Comber H., De Angelis R., de Lacerda G. F., de Munain A. L., Diaz Garcia J. M., Diba C. S., Dimitrova N., Dusek L., Engel J., Eycken E. V., Falcini F., Ferretti S., Filiberti R. A., Fusco M., Galceran J., Gatta G., Gavin A., Gennaro V., Gentilini M., Giacomin A., Gozdz S., Grosclaude P., Guizard A. -V., Hackl M., Heidrich J., Henau K., Holleczek B., Huws D. W., Iannelli A., Johannesen T. B., Jonasson J. G., Kepska K., Knijn A., Konzelmann I., Kunkler I., Lapotre-Ledoux B., Larranaga N., Leinonen M., Luttmann S., M. Ess S., Madeddu A., Magi M., Malila N., Mallone S., Mangone L., Marani E., Marcos-Gragera R., Maspero S., Maynadie M., Mazzoleni G., Michiara M., Miranda A., Molinie F., Monnereau A., Moreno-Iribas C., Mousavi M., Navarro C., Nennecke A., Nicolai N., Pannozzo F., Pierannunzio D., Piffer S., Pildava S., Primic-Zakelj M., Rachtan J., Rashbass J., Ricci P., Robaszkiewic M., Rossi S., Rugge M., Salmeron D., Sanchez M. J., Santaquilani M., Schubert-Fritschle G., Schvartz C., Sekerija M., Sensi F., Serraino D., Smailyte G., Spagnoli G., Stabenow R., Stracci F., Sutera Sardo A., Tagliabue G., Tavilla A., Torrella-Ramos A., Trama A., Tretarre B., Troussard X., Tumino R., Usala M., Velten M., Visser O., Vitale F., Woronoff A. -S., Ziino A.   +121 more
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METTL3 potentiates resistance to cisplatin through m6A modification of TFAP2C in seminoma

Journal of Cellular and Molecular Medicine, 2020
Testicular germ cell tumours (TGCTs) rank as the most common malignancy in men aged 20‐34 years, and seminomas are the most type of TGCTs. As a crucial anti‐tumour agent with explicit toxicity, cisplatin may render resistance through intertwined ...
Jingchao Wei, Yinghao Yin, Jun Zhou, Hanfei Chen, jingxuan peng, Jianfu Yang, Yuxin Tang   +6 more
semanticscholar   +1 more source

Androgen receptor polymorphisms and testicular cancer risk [PDF]

, 2015
Testicular cancer (TC) is currently the most common malignant solid tumour in Caucasian males aged 15-39 years. Epidemiological evidence suggests that its onset may be due to an imbalance in the action of steroidal sex hormones and their receptors.
CARLINI, TANIA, F. Rizzo, GANDINI, Loredana, GIANNANDREA, FABRIZIO, GRASSETTI, Daniele, LENZI, Andrea, LOMBARDO, Francesco, MASCIANDARO, PAOLA, PAOLI, Donatella, V. Figura   +9 more
core   +1 more source

Prognostic factors in seminomas with special respect to HCG: Results of a prospective multicenter study [PDF]

, 1999
Objective: In a prospective multicenter trial, it was our intention to elucidate clinical prognostic factors of seminomas with special reference to the importance of human chorionic gonadotropin (HCG) elevations in histologically pure seminomas. Methods:
Bussar-Maatz, R., Dieckmann, K. P., Fassbinder, J., Hartmann, M., Löhrs, U., Mann, K., Schubert, G. E., Weissbach, L.   +7 more
core   +1 more source

Nuclear Localization of PTTG1 Promotes Migration and Invasion of Seminoma Tumor through Activation of MMP-2

Cancers, 2020
Simple Summary Seminoma is the most common subtype of testicular germ cell tumors (TGCTs) and its molecular patterns have not been clarified. The pituitary tumor-transforming gene 1 (PTTG1) is a securin and its overexpression is reported in many cancers.
Emanuela Teveroni, F. Di Nicuolo, G. Bianchetti, A. Epstein, G. Grande, G. Maulucci, M. De Spirito, A. Pontecorvi, D. Milardi, F. Mancini   +9 more
semanticscholar   +1 more source

Three-gene prognostic biomarkers for seminoma identified by weighted gene co-expression network analysis.

PLoS ONE, 2020
Testicular germ cell tumors (TGCTs) are common in young males, and seminoma accounts for a large proportion of TGCTs. However, there are limited records on the exploration of novel biomarkers for seminoma.
Hualin Chen, Gang Chen, Yang Pan, Xiaoxiang Jin   +3 more
doaj   +1 more source

Testicular cancer and sperm DNA damage: short- and long-term effects of antineoplastic treatment [PDF]

, 2015
The aim of this study was to investigate sperm DNA damage induced by chemo- and radiotherapy in patients with testicular cancer to provide data on the extent and persistence of nuclear damage that might affect individual reproductive potential.
F. Rizzo, G. Leter, GALLO, MARIAGRAZIA, GANDINI, Loredana, LENZI, Andrea, LOMBARDO, Francesco, M. Spano, PAOLI, Donatella   +7 more
core   +1 more source

Kelch-like Protein 11 Antibodies in Seminoma-Associated Paraneoplastic Encephalitis.

New England Journal of Medicine, 2019
A 37-year-old man with a history of seminoma presented with vertigo, ataxia, and diplopia. An autoantibody specific for kelch-like protein 11 (KLHL11) was identified with the use of programmable phage display.
C. Mandel-Brehm, D. Dubey, T. Kryzer, B. O’Donovan, B. Tran, S. Vazquez, H. Sample, K. Zorn, Lillian M. Khan, Ian O. Bledsoe, A. McKeon, S. Pleasure, V. Lennon, J. Derisi, M. Wilson, S. Pittock   +15 more
semanticscholar   +1 more source

Giant seminoma case with very small yolk sac and embryo carcinoma components, detected by intensive histopathological examination

Human Pathology: Case Reports, 2016
We experienced the giant seminoma with 18 × 10 × 10 cm sized and about 2.6 kg weight of 25 year old patient. We intensively examined the histological tissue type distributions in this giant seminoma. Most of the tumor consisted of seminoma components. In
Takeo Nakaya, MD, Shuichiro Kobayashi, MD, Satoshi Kitahara, MD, Akira Tanaka, MD, Hiroshi Kamma, MD, Akio Komatsu, MD   +5 more
doaj   +1 more source

Transient increases in intracellular calcium and reactive oxygen species levels in TCam-2 cells exposed to microgravity [PDF]

, 2017
The effects of microgravity on functions of the human body are well described, including alterations in the male and female reproductive systems. In the present study, TCam-2 cells, which are considered a good model of mitotically active male germ cells,
Catizone, A, Guarnieri, S, Mariggiò, M. A., Morabito, C, Ricci, G, Schiraldi, C   +5 more
core   +2 more sources