Results 81 to 90 of about 245,833 (114)

Cellular senescence: from homeostasis to pathological implications and therapeutic strategies

Frontiers in Immunology
Cellular aging is a multifactorial and intricately regulated physiological process with profound implications. The interaction between cellular senescence and cancer is complex and multifaceted, senescence can both promote and inhibit tumor progression ...
Chunhong Li, Yixiao Yuan, YingDong Jia, Qiang Zhou, Qiang Wang, Xiulin Jiang   +5 more
doaj   +1 more source

Identification of cellular senescence-related genes as biomarkers for lupus nephritis based on bioinformatics

Frontiers in Genetics
BackgroundLupus nephritis (LN) is one of the most common and severe complications of systemic lupus erythematosus with unclear pathogenesis. The most accurate diagnosis criterion of LN is still renal biopsy and nowadays treatment strategies of LN are far
Wei Chen, Wei Chen, Xiaofang Wang, Xiaofang Wang, Guoshun Huang, Guoshun Huang, Qin Sheng, Enchao Zhou, Enchao Zhou   +8 more
doaj   +1 more source

PseudoCell: A Multivalued Logical Regulatory Network to Investigate Premature Senescence Dynamics and Heterogeneity

Aging Medicine
Purpose Premature cellular senescence is a pivotal process in aging and age‐related diseases, triggered by various stressors. However, this is not a homogeneous phenotype, but a heterogeneous cellular state composed of multiple senescence programs with ...
Vinícius Pierdoná, Patrícia Lavandoski, Rafael Moura Maurmann, Guilherme Antônio Borges, Jose Carlos Merino Mombach, Fátima Theresinha Costa Rodrigues Guma, Florencia María Barbé‐Tuana   +6 more
doaj   +1 more source

The Regulation of Cellular Senescence in Cancer

Biomolecules
Cellular senescence is a stable state of cell cycle arrest caused by telomere shortening or various stresses. After senescence, cells cease dividing and exhibit many age-related characteristics. Unlike the halted proliferation of senescence cells, cancer
Xianhong Zhang, Yue Gao, Siyu Zhang, Yixiong Wang, Yitian Du, Shuailin Hao, Ting Ni   +6 more
doaj   +1 more source

seneR: An R package for comprehensive senescence assessment and its application in type 2 diabetes and osteoarthritis

Computational and Structural Biotechnology Journal
Background: Cellular senescence is a key driver of aging and chronic diseases. However, accurately identifying senescent cells is challenging due to limitations of conventional biomarkers and senescence heterogeneity.
Yi Zhang, Xinming Zhang, Cheng Chen, Bing Li, Yao Lu, Xin Ma, Yunfeng Yang   +6 more
doaj   +1 more source

P429: THERAPY-INDUCED SENESCENCE TRIGGERS UPREGULATION OF ANTIGEN PRESENTATION VIA PRC2 INHIBITION AND PROMOTES ANTI-TUMOUR IMMUNITY IN ACUTE MYELOID LEUKAEMIA

HemaSphere, 2023
Diego Gilioli, Simona Fusco, Teresa Tavella, Kety Giannetti, Anastasia Conti, Santoro Antonella, Edoardo Carsana, Stefano Beretta, Martin Schönlein, Valentina Gambacorta, Federico Aletti, Matteo Giovanni Carrabba, Chiara Bonini, Fabio Ciceri, Ivan Merelli, Luca Vago, Clemens A. Schmitt, Raffaella DI Micco   +17 more
doaj   +1 more source

Regulation of Leaf Senescence by Cytokinin, Sugars, and Light. Effects on NADH-Dependent Hydroxypyruvate Reductase [PDF]

, 1998
The aim of this study was to investigate the interactions between cytokinin, sugar repression, and light in the senescence-related decline in photosynthetic enzymes of leaves. In transgenic tobacco (Nicotiana tabacum) plants that induce the production of
Lea, P.J., Leegood, R.C., Quick, W.P., von Schaewen, A., Wingler, A.   +4 more
core   +1 more source

Global m6A RNA and whole 5mC DNA methylation specifically contribute to cell replicative and premature senescence induced by extrinsic oxidative stress

mSystems
Hydrogen peroxide (H2O2) is a typical representative substance of environmental oxidative stress. Exogenous substances can alter epigenetic modifications from the DNA to the RNA level through oxidative stress.
Chenyu Zhu, Tingting Huang, Jiaqi Fu, Min Li, Luyi Tan, Xinyu Zhang, Wenli Cheng, Caiyun Lai, Zhangying Wang, Wenji Zhang, Wenjuan Zhang   +10 more
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Detection of senescence using machine learning algorithms based on nuclear features

Nature Communications
Cellular senescence is a stress response with broad pathophysiological implications. Senotherapies can induce senescence to treat cancer or eliminate senescent cells to ameliorate ageing and age-related pathologies.
Imanol Duran, Joaquim Pombo, Bin Sun, Suchira Gallage, Hiromi Kudo, Domhnall McHugh, Laura Bousset, Jose Efren Barragan Avila, Roberta Forlano, Pinelopi Manousou, Mathias Heikenwalder, Dominic J. Withers, Santiago Vernia, Robert D. Goldin, Jesús Gil   +14 more
doaj   +1 more source

Comprehensive Cellular Senescence Evaluation to Aid Targeted Therapies

Research
Drug resistance to a single agent is common in cancer-targeted therapies, and rational drug combinations are a promising approach to overcome this challenge. Many Food and Drug Administration-approved drugs can induce cellular senescence, which possesses
Xiaolan Zhou, Xiaofeng Zhu, Weixu Wang, Jing Wang, Haimei Wen, Yuqi Zhao, Jiayu Zhang, Qiushi Xu, Zhaozhao Zhao, Ting Ni   +9 more
doaj   +1 more source