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Immune checkpoint inhibitors as senolytic agents
Cell Research, 2022Parminder Singh +2 more
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Senolytic therapy in mild Alzheimer’s disease: a phase 1 feasibility trial
Nature Medicine, 2023Mitzi M Gonzales +2 more
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Dual Activated Senolytic Prodrug
We present the concept of a precise senolytic prodrug activated in a two-stepmanner, functioning as a chemical AND gate. This design ensures therelease of a cytotoxic agent exclusively in senescent cells thatsimultaneously exhibit two key hallmarks of senescence: increased β-D-galactosidase activity detectable at suboptimal pH ≈6 (the commonly ...openaire +1 more source
Senolytic Therapy for Cerebral Ischemia-Reperfusion Injury
International Journal of Molecular Sciences, 2021Songhyun Lim, Tae Jung Kim, Sang-Bae Ko
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