Results 81 to 90 of about 1,766,628 (360)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Sensitivity, Specificity, and Predictive Values: Foundations, Pliabilities, and Pitfalls in Research and Practice

Frontiers in Public Health, 2017
Within the context of screening tests, it is important to avoid misconceptions about sensitivity, specificity, and predictive values. In this article, therefore, foundations are first established concerning these metrics along with the first of several ...
Robert Trevethan
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Polymerization shrinkage stress of composite resins and resin cements – What do we need to know?

Brazilian Oral Research, 2017
Polymerization shrinkage stress of resin-based materials have been related to several unwanted clinical consequences, such as enamel crack propagation, cusp deflection, marginal and internal gaps, and decreased bond strength.
Carlos José SOARES, André Luis FARIA-E-SILVA, Monise de Paula RODRIGUES, Andomar Bruno Fernandes VILELA, Carmem Silvia PFEIFER, Daranee TANTBIROJN, Antheunis VERSLUIS   +6 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Performance of a rapid diagnostic test for the detection of visceral leishmaniasis in a large urban setting

Revista da Sociedade Brasileira de Medicina Tropical, 2013
Introduction Rapid diagnostic tests (RDTs) may improve the early detection of visceral leishmaniasis (VL), but their real-world performance requires additional study.
Alexandre Sampaio Moura, Helen Maria Ramos de Oliveira Lopes, Maria Vitoria Assumpcao Mourao, Maria Helena Franco Morais   +3 more
doaj   +1 more source

Proper Estimation of Sensitivity and Specificity [PDF]

Clinical and Vaccine Immunology, 2006
I write to express concern about the diagnostic accuracy statements of Eda et. al. concerning a new Johne's disease enzyme-linked immunosorbent assay (ELISA) (2). The diagnostic sensitivity of this new ELISA for bovine paratuberculosis, reported to be 100%, was based on only 64 (according to the Materials and Methods) or 51 (according to the Results)
openaire   +2 more sources

PTU-075 Systematic Review And Meta-analysis: Sensitivity And Specificity Of Tc-99m Hmpao Labelled White Cell Scintigraphy In The Diagnosis Of Active Inflammatory Bowel Disease [PDF]

, 2014
C. Neol Williams, Alexander C. Ford, Andrew Poullis   +2 more
openalex   +1 more source