Results 101 to 110 of about 2,923,375 (341)

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Cloud-based data-intensive framework towards fault diagnosis in large-scale petrochemical plants [PDF]

, 2016
Industrial Wireless Sensor Networks (IWSNs) are expected to offer promising monitoring solutions to meet the demands of monitoring applications for fault diagnosis in large-scale petrochemical plants, however, involves heterogeneity and Big Data problems
Chen, Yuanfang, Huo, Zhiqiang, Mukherjee, Mithun, Shu, Lei, Zhou, Zhangbing   +4 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Tolerating failures of continuous-valued sensors [PDF]

One aspect of fault tolerance in process control programs is the ability to tolerate sensor failure. A methodology for transforming a process control program that cannot tolerate sensor failures onto one that can is presented.
Marzullo, Keith
core   +1 more source

Fault-tolerant observer design with a tolerance measure for systems with sensor failure [PDF]

, 2016
A fault-tolerant switching observer design methodology is proposed. The aim is to maintain a desired level of closed-loop performance under a range of sensor fault scenarios while the fault-free nominal performance is optimized.
Jaimoukha, IM, Segundo Sevilla, Zhang, C
core   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Flight test results of the Strapdown hexad Inertial Reference Unit (SIRU). Volume 1: Flight test summary [PDF]

Flight test results of the strapdown inertial reference unit (SIRU) navigation system are presented. The fault-tolerant SIRU navigation system features a redundant inertial sensor unit and dual computers.
Bjorkman, W. S., Hruby, R. J.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

A New Belief-Rule-Based Method for Fault Diagnosis of Wireless Sensor Network

IEEE Access, 2018
In the technology of wireless sensor network (WSN), wireless sensor fault diagnosis based on fusion data analysis has attracted attention in the wireless sensor field.
Wei He, Pei-Li Qiao, Zhi-Jie Zhou, Guan-Yu Hu, Zhi-Chao Feng, Hang Wei   +5 more
doaj   +1 more source