Results 121 to 130 of about 149,683 (183)

Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
Inhibition of focal adhesion kinase autophosphorylation (Y397) in adipocytes is associated with reduced glucose uptake, likely via the disruptions of Arp2/3 and Rac1 activity, leading to impaired cytoskeletal remodeling and consequential impairment of GLUT4 translocation. B = binding, GTP = GTP‐loading, P = phosphorylation.
Franziska Kopietz, Mathis Neuhaus, Andrea Borreguero‐Muñoz, Dmytro Kryvokhyzha, Karin G. Stenkula   +4 more
wiley   +1 more source

Growth inhibition of Saccharomyces cerevisiae by SUMO-specific nanobodies. [PDF]

Sci Rep
Suresh P, Jim SZ, Sahay I, Tang AY, Wijne C, Gan J, Pishesha N, Avalos JL, Ploegh H.   +8 more
europepmc   +1 more source

A Robust and Easy Protein Purification Method Using SpyDock-Modified Resin. [PDF]

Bio Protoc
Yang X, Lin Z, Xiang Y, Chen B, Lao Z.
europepmc   +1 more source

Identification of Key Active‐Site Positions Controlling the Chemoselectivity of Aspergillus Brasiliensis Unspecific Peroxygenase

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
Unspecific peroxygenase (UPO) from Aspergillus brasiliensis AbrUPO catalyzes the aromatic hydroxylation of substituted benzenes. By integrating structural elements from well‐characterized UPOs in AbrUPO variants, position 186 was identified as a critical determinant of enzyme chemoselectivity.
Fabian Schmitz, Maike Hoffrogge, Katja Koschorreck, Yasuhisa Fukuta, Alessandra Raffaele, Florian Tieves, Thomas Hilberath, Frank Hollmann, Vlada B. Urlacher   +8 more
wiley   +1 more source

Interaction with IP6K1 supports pyrophosphorylation of substrate proteins by the inositol pyrophosphate 5-InsP7. [PDF]

Biosci Rep
Hamid A, Ladke JS, Shah A, Ganguli S, Pal M, Singh A, Bhandari R.   +6 more
europepmc   +1 more source

Reduced Palmitoylation of SQSTM1/p62 in Huntington Disease Is Associated With Impaired Autophagy

The FASEB Journal, Volume 39, Issue 9, 15 May 2025.
Sequestosome 1 (SQSTM1)/p62 is a receptor for autophagy required to deliver damaged organelles and aggregated proteins to the lysosome for degradation. SQSTM1 undergoes palmitoylation, the reversible addition of the saturated fatty acid palmitate to cysteines.
F. Abrar, M. C. Davies, Y. Alshehabi, A. Kumar, A. Dang, Y. T. N. Nguyen, J. Collins, N. S. Caron, J. S. Choudhary, S. S. Sanders, M. O. Collins, M. R. Hayden, D. D. O. Martin   +12 more
wiley   +1 more source

Broccoli Sprout Extract Suppresses Particulate-Matter-Induced Matrix-Metalloproteinase (MMP)-1 and Cyclooxygenase (COX)-2 Expression in Human Keratinocytes by Direct Targeting of p38 MAP Kinase. [PDF]

Nutrients
Yun J, Kim JE.
europepmc   +1 more source

Development of an efficient expression system for human chaperone BiP in Pichia pastoris: production optimization and functional validation. [PDF]

Microb Cell Fact
Žitkus E, Čiplys E, Žiaunys M, Sakalauskas A, Slibinskas R.   +4 more
europepmc   +1 more source

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance. [PDF]

Nat Commun
Chauhan AS, Mackintosh MJW, Cassar J, Lanz AJ, Jamshad M, Mackay HL, Garvin AJ, Walker AK, Jhujh SS, Carlomagno T, Leney AC, Stewart GS, Morris JR.   +12 more
europepmc   +1 more source

Advances in the structural characterization and pharmacological activity of Salvia miltiorrhiza polysaccharides. [PDF]

Front Chem
Yang K, Liu YJ, Zhang JN, Chen YJ, Yang J, Xiao JP, Lin HB, Yang HJ.   +7 more
europepmc   +1 more source