Results 141 to 150 of about 1,083,142 (408)

Goal-directed resuscitation for patients with early septic shock.

New England Journal of Medicine, 2014
BACKGROUND Early goal-directed therapy (EGDT) has been endorsed in the guidelines of the Surviving Sepsis Campaign as a key strategy to decrease mortality among patients presenting to the emergency department with septic shock. However, its effectiveness
S. Peake, A. Delaney, M. Bailey, R. Bellomo, P. Cameron, D. J. Cooper, A. Higgins, A. Holdgate, B. Howe, S. Webb, Patricia Williams   +10 more
semanticscholar   +1 more source

Prefrontal FGF1 Signaling is Required for Accumbal Deep Brain Stimulation Treatment of Addiction

Advanced Science, EarlyView.
This research delineates that a cortical‐accumbal pathway and local FGF1 signaling in the medial prefrontal cortex are critical for NAc‐DBS to be effective in altering morphine CPP. These findings demonstrate a top‐down motif to regulate the therapeutic effects of subcortical DBS on addiction and support the potential for addiction treatments involving
Wan‐Kun Gong, Xue Li, Le Wang, Qian Yang, Alix Tiran‐Cappello, Zhichao Liang, James Samsom, Quanying Liu, He Lin, Christelle Baunez, Fang Liu, Ti‐Fei Yuan   +11 more
wiley   +1 more source

Evaluating recommender systems for AI-driven biomedical informatics [PDF]

arXiv, 2019
Motivation: Many researchers with domain expertise are unable to easily apply machine learning to their bioinformatics data due to a lack of machine learning and/or coding expertise. Methods that have been proposed thus far to automate machine learning mostly require programming experience as well as expert knowledge to tune and apply the algorithms ...
arxiv  

Surviving sepsis campaign: research priorities for sepsis and septic shock

Intensive Care Medicine, 2018
ObjectiveTo identify research priorities in the management, epidemiology, outcome and underlying causes of sepsis and septic shock.DesignA consensus committee of 16 international experts representing the European Society of Intensive Care Medicine and ...
C. Coopersmith, D. De Backer, C. Deutschman, R. Ferrer, I. Lat, F. Machado, G. Martin, I. Martín-Loeches, M. Nunnally, M. Antonelli, Laura Evans, J. Hellman, S. Jog, J. Kesecioglu, M. Levy, A. Rhodes   +15 more
semanticscholar   +1 more source

Autophagy Related 5 Promotes Mitochondrial Fission and Inflammation via HSP90‐HIF‐1α‐Mediated Glycolysis in Kidney Fibrosis

Advanced Science, EarlyView.
When the normal kidney is subjected to injurious stimuli, it can lead to persistent activation of ATG5. The activation of ATG5 promotes HSP90‐HIF‐1α interaction, resulting in stabilization of HIF‐1α and subsequent activation of glycolysis. Consequently, this process contributes to mitochondrial fission and inflammation, ultimately culminating in kidney
Yan Hu, Jinqing Li, Hui Chen, Yingfeng Shi, Xiaoyan Ma, Yi Wang, Xialin Li, Qin Zhong, Yishu Wang, Daofang Jiang, Shougang Zhuang, Na Liu   +11 more
wiley   +1 more source

Noninvasive ventilation failure in patients with hypoxemic respiratory failure: the role of sepsis and septic shock

Therapeutic Advances in Respiratory Disease, 2019
Background: Sepsis and septic shock are common in noninvasive ventilation (NIV) patients. However, studies on the association between sepsis and NIV failure are lacking.
Jun Duan, Lijuan Chen, Guopeng Liang, Weiwei Shu, Liucun Li, Ke Wang, Shengyu Wang, Xiaoyi Liu, Chunfeng He, Dehua He, Qimin Chen, Bilin Wei, Baixu Chen, Yuzhen Shu, Yao Tian, Liping Fan, Xiaoli Han, Rui Zhang, Xiangmei Yang, Yan Peng, Dong Wan, Xiaoying Chen, Lin Ye, Shijing Tian, Qiong Huang, Lei Jiang, Linfu Bai, Lintong Zhou   +27 more
doaj   +1 more source

Melatonin and cortisol exhibit different circadian rhythm profiles during septic shock depending on timing of onset: a prospective observational study

Annals of Intensive Care, 2018
Background Septic shock has been found to disrupt circadian rhythms. Moreover, timing of onset has been associated with different circadian profiles in experimental studies.
Eleni N. Sertaridou, Ioanna G. Chouvarda, Konstantinos I. Arvanitidis, Eirini K. Filidou, George C. Kolios, Ioannis N. Pnevmatikos, Vasilios E. Papaioannou   +6 more
doaj   +1 more source

Evolution of neutrophil apoptosis in septic shock survivors and nonsurvivors [PDF]

, 2012
Producción CientíficaThe aims were to analyze the temporal evolution of neutrophil apoptosis, to determine the differences in neutrophil apoptosis among 28-day survivors and nonsurvivors, and to evaluate the use of neutrophil apoptosis as a predictor of ...
Bermejo Martín, Jesús Francisco, Bobillo, Felipe, Bustamante Munguira, Juan, Castrodeza Sanz, José Javier, Fierro Lorenzo, María Inmaculada, Fonteriz García, Rosalba Inés, Gómez Herreras, José Ignacio, Gómez Sánchez, Esther, Heredia Rodríguez, María, Tamayo Gómez, Eduardo, Álvarez González, Francisco Javier   +10 more
core   +2 more sources

Mortality related to severe sepsis and septic shock among critically ill patients in Australia and New Zealand, 2000-2012.

Journal of the American Medical Association (JAMA), 2014
IMPORTANCE Severe sepsis and septic shock are major causes of mortality in intensive care unit (ICU) patients. It is unknown whether progress has been made in decreasing their mortality rate. OBJECTIVE To describe changes in mortality for severe sepsis
K. Kaukonen, M. Bailey, Satoshi Suzuki, D. Pilcher, R. Bellomo   +4 more
semanticscholar   +1 more source

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source