Results 141 to 150 of about 1,124,600 (388)

Association of metformin administration after septic shock with short-term and long-term survival in septic shock patients with diabetes

Annals of Intensive Care
Background In addition to glycemic control, the anti-inflammatory effects and protective effect of metformin on sepsis have been reported in animal studies, which may be beneficial for patients with septic shock.
Bo-Yeong Jin, Sukyo Lee, Woosik Kim, Jong-Hak Park, Hanjin Cho, Sungwoo Moon, Sejoong Ahn   +6 more
doaj   +1 more source

Septic Shock in Pyogenic Liver Abscess: Clinical Considerations

The Korean Journal of Gastroenterology, 2016
Background : /Aims: Pyogenic liver abscess (PLA) is a life-threatening condition, despite advances in diagnostic technology and strategies for treatment. A strong predictor of mortality in this condition is septic shock.
A Reum Cho, Tae Hee Lee, Min Ji Park, Sun Hee Oh, Joo Ah Lee, Joo Ho Park, Ki Hyun Ryu, Hoon Sup Koo, Kyung Ho Song, Sun Moon Kim, Kyu Chan Huh, Young Woo Choi, Young Woo Kang   +12 more
doaj   +1 more source

Comparative safety and efficacy of vasopressors for mortality in septic shock: A network meta-analysis

, 2015
© 2015, © The Intensive Care Society 2015.Introduction: Septic shock is a life-threatening condition requiring vasopressor agents to support the circulatory system. Several agents exist with choice typically guided by the specific clinical scenario.
Gordon, AC, Gurusamy, KS, Maruthappu, M, Nagendran, M   +3 more
core   +1 more source

Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy

Annals of Intensive Care, 2018
In patients with septic shock, the administration of fluids during initial hemodynamic resuscitation remains a major therapeutic challenge. We are faced with many open questions regarding the type, dose and timing of intravenous fluid administration ...
M. Malbrain, N. Van Regenmortel, B. Saugel, B. de Tavernier, P. Van Gaal, O. Joannes-Boyau, J. Teboul, T. Rice, M. Mythen, X. Monnet   +9 more
semanticscholar   +1 more source

Targeted Inhibition of CD74+ Macrophages by Luteolin via CEBPB/P65 Signaling Ameliorates Osteoarthritis Progression

Advanced Science, EarlyView.
This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng, Bo Yu, Lei Zhang, Zhaowen Xue, Lutian Yao, Qingjun Yang, Zitao Liu, Sizhi Wu, Yongquan Huang, Xiaofei Zheng, Huiying Guo, Songwei Huan, Tao Jiang, Huajun Wang, Yulong Wei, Tao Gui   +15 more
wiley   +1 more source

Immune Predictors of Radiotherapy Outcomes in Cervical Cancer

Advanced Science, EarlyView.
This study reveals dynamic immune remodeling in cervical cancer following radiotherapy. Single‐cell analysis identifies the C3/C3AR1 axis as a central mediator of epithelial–myeloid crosstalk, whose inhibition reduces treatment efficacy in mice. Guided by these insights, the eight‐feature machine‐learning model: Cervical Cancer Radiotherapy Immune ...
Linghao Wang, Jie Zhu, Zequn Ding, Zhiyuan Xie, Xingchen Liu, Feihong Zhang, Xiaojun Liu, Yan Zhang, Haiyan Chen   +8 more
wiley   +1 more source

DRESS syndrome presenting like septic shock [PDF]

, 2013
G. Parkins, Benjamin White
openalex   +1 more source

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
In HCC, circZNF79(5) binds to YBX1 and functions as an oncogene, recruits BRCC36 to remove K63‐linked ubiquitin chains to stabilize YBX1 protein, and promotes HCC progression via the HIF‐1 signaling pathway. Conversely, circZNF79(5) silencing activates the AMPK/mTOR pathway, inducing p62‐mediated selective autophagic degradation of YBX1.
Xueqiang Guo, Lingling Xi, Yukun Liu, Wenbao Lv, Tianzi Li, Andong Ju, Zhenlin Fan, Yaping Shen, Zhuang Qian, Weiyun Wang, Zhuo Liang, Wenjuan Song, Kaiwen Chang, Shuangping Ma, Junhe Zhang, Tao Han, Kun You, Cunshuan Xu, Lei Wang, Weisheng Guo, Wenjie Ren   +20 more
wiley   +1 more source

Extracorporeal membrane oxygenation in adult patients with sepsis and septic shock: Why, how, when, and for whom

, 2023
Hongling Zhang, Youdong Xu, Xin Huang, Shunyin Yang, Ruiting Li, Yongran Wu, Xiaojing Zou, Yu Yuan, You Shang   +8 more
openalex   +1 more source