Results 121 to 130 of about 29,786,749 (389)
Regulatory Sequence Analysis Tools [PDF]
Nucleic Acids Research, 2003 The web resource Regulatory Sequence Analysis Tools (RSAT) (http://rsat.ulb.ac.be/rsat) offers a collection of software tools dedicated to the prediction of regulatory sites in non-coding DNA sequences. These tools include sequence retrieval, pattern discovery, pattern matching, genome-scale pattern matching, feature-map drawing, random sequence ...
openaire +5 more sources
Frontiers in ImmunologyMycobacterium avium subspecies paratuberculosis (MAP) is a global concern in modern livestock production worldwide. The available vaccines against paratuberculosis do not offer optimal protection and interfere with the diagnosis of bovine tuberculosis ...
Kari Lybeck +7 more
doaj +1 more source
Protein sectors: statistical coupling analysis versus conservation
, 2014 Statistical coupling analysis (SCA) is a method for analyzing multiple sequence alignments that was used to identify groups of coevolving residues termed "sectors".
Colwell, Lucy J. +2 more
core +4 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Analysis of Haplotype Sequences
, 2016 In this era of whole-genome, next-generation sequencing, it is important to have a clear understanding of the concept of “haplotype”. We show here that most of the important regions of the genome can be described in terms of polymorphic frozen blocks (PFB). At each PFB, there are numerous, even hundreds, of alternative ancestral haplotypes. Haplotypes,
Lloyd, S.S., Steele, E.J., Dawkins, R.L.
openaire +3 more sources
Pathways to death: The co-occurrence of physical and mental health in the last years of life
Demographic Research, 2018 Background: Physical and mental health are important markers of quality of life. Little is known about how they unfold in tandem in the last years of life.
Marcel Raab, Anette Fasang, Moritz Hess
doaj +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Emerging Infectious Diseases, 2017 Whole-genome sequencing is rapidly replacing current molecular typing methods for surveillance purposes. Our study evaluates core-genome single-nucleotide polymorphism analysis for outbreak detection and linking of sources of Salmonella enterica serovar ...
Pernille Gymoese +5 more
doaj +1 more source
Automatic assessment of sequence diagrams [PDF]
, 2008 In previous work we showed how student-produced entity-relationship diagrams (ERDs) could be automatically marked with good accuracy when compared with human markers.
Smith, Neil, Thomas, Pete, Waugh, Kevin
core +1 more source
Molecular Therapy: Nucleic Acids, 2015 High-throughput sequence (HTS) analysis of combinatorial selection populations accelerates lead discovery and optimization and offers dynamic insight into selection processes. An underlying principle is that selection enriches high-fitness sequences as a
Khalid K. Alam, J. L. Chang, D. H. Burke
semanticscholar +1 more source