Cells, shared memory and breaking the PTM code
Pau Creixell, Rune Linding
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The PDTIS bioinformatics platform: from sequence to function - DOI: 10.3395/reciis.v1i2.Sup.98en
Since the eighties, Bioinformatics has acquired a growing importance in the biological sciences. Due to the complexity of hardware and software tools, and the need for a specialized management of network infrastructure, data processing and storage, many ...
Thomas Dan Otto+3 more
doaj
Analysis of the code relating sequence to conformation in globular proteins. An informational analysis of the role of the residue in determining the conformation of its neighbours in the primary sequence [PDF]
Barry Robson, Roger H. Pain
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This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani+14 more
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Amino acid analysis and N—terminal sequence determination of P7 proteolipid apoprotein from human myelin [PDF]
J.L. Nussbaum+4 more
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Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen+12 more
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Tritium sequence analysis of oligoribonucleotides: a combination of post-labeling and thin-layer chromatographic techniques for the analysis of partial snake venom phosphodiesterase digests [PDF]
M. Sivarajan+4 more
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Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova+18 more
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