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Parametric Inference for Biological Sequence Analysis [PDF]
One of the major successes in computational biology has been the unification, using the graphical model formalism, of a multitude of algorithms for annotating and comparing biological sequences.
B. Sturmfels+5 more
core +4 more sources
Differential expression analysis for sequence count data [PDF]
*Motivation:* High-throughput nucleotide sequencing provides quantitative readouts in assays for RNA expression (RNA-Seq), protein-DNA binding (ChIP-Seq) or cell counting (barcode sequencing).
A Agresti+32 more
core +3 more sources
What Can We Learn from a Metagenomic Analysis of a Georgian Bacteriophage Cocktail?
Phage therapy, a practice widespread in Eastern Europe, has untapped potential in the combat against antibiotic-resistant bacterial infections. However, technology transfer to Western medicine is proving challenging. Bioinformatics analysis could help to
Henrike Zschach+11 more
doaj +1 more source
BEAST: Bayesian evolutionary analysis by sampling trees [PDF]
Background The evolutionary analysis of molecular sequence variation is a statistical enterprise. This is reflected in the increased use of probabilistic models for phylogenetic inference, multiple sequence alignment, and molecular population genetics ...
Drummond, Alexei J., Rambaut, Andrew
core +3 more sources
Asymptotic Analysis of q-Recursive Sequences [PDF]
For an integer $q\ge2$, a $q$-recursive sequence is defined by recurrence relations on subsequences of indices modulo some powers of~$q$. In this article, $q$-recursive sequences are studied and the asymptotic behavior of their summatory functions is analyzed.
arxiv +1 more source
Bayesian prediction of microbial oxygen requirement [v1; ref status: indexed, http://f1000r.es/1m6]
Background: Prediction of the optimal habitat conditions for a given bacterium, based on genome sequence alone would be of value for scientific as well as industrial purposes. One example of such a habitat adaptation is the requirement for oxygen.
Dan B. Jensen, David W. Ussery
doaj +1 more source
Motion sequence analysis in the presence of figural cues [PDF]
Published in final edited form as: Neurocomputing. 2015 January 5, 147: 485–491The perception of 3-D structure in dynamic sequences is believed to be subserved primarily through the use of motion cues.
Sinha, Pawan, Vaina, Lucia M
core +1 more source
Quantification of within-sample genetic heterogeneity from SNP-array data
Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement.
Pierre Martinez+5 more
doaj +1 more source
The study of microbial pangenomes relies on the computation of gene families, i.e. the clustering of coding sequences into groups of essentially similar genes. There is no standard approach to obtain such gene families.
Lars-Gustav Snipen, David W Ussery
doaj +1 more source
Gene expression, DNA methylation, and their organizational relationships are commonly altered in lung squamous cell carcinoma (LUSC). To elucidate these complex interactions, we reconstructed a differentially expressed gene network and a differentially ...
Yusri Dwi Heryanto+2 more
doaj +1 more source