Results 21 to 30 of about 2,665,426 (306)
Quantification of within-sample genetic heterogeneity from SNP-array data
Scientific Reports, 2017 Intra-tumour genetic heterogeneity (ITH) fosters drug resistance and is a critical hurdle to clinical treatment. ITH can be well-measured using multi-region sampling but this is costly and challenging to implement.
Pierre Martinez +5 more
doaj +1 more source
F1000Research, 2013 The study of microbial pangenomes relies on the computation of gene families, i.e. the clustering of coding sequences into groups of essentially similar genes. There is no standard approach to obtain such gene families.
Lars-Gustav Snipen, David W Ussery
doaj +1 more source
F1000Research, 2012 The study of microbial pangenomes relies on the computation of gene families, i.e. the clustering of coding sequences into groups of essentially similar genes. There is no standard approach to obtain such gene families.
Lars-Gustav Snipen, David W Ussery
doaj +1 more source
Scientific Reports, 2022 Gene expression, DNA methylation, and their organizational relationships are commonly altered in lung squamous cell carcinoma (LUSC). To elucidate these complex interactions, we reconstructed a differentially expressed gene network and a differentially ...
Yusri Dwi Heryanto +2 more
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Antibody repertoire sequencing analysis: Antibody repertoire sequencing analysis
Acta Biochimica et Biophysica Sinica, 2022 High-throughput sequencing for B cell receptor (BCR) repertoire provides useful insights for the adaptive immune system. With the continuous development of the BCR-seq technology, many efforts have been made to develop methods for analyzing the ever-increasing BCR repertoire data.
Zhang, Senxin +4 more
openaire +4 more sources
mSphere, 2018 Typing of methicillin-resistant Staphylococcus aureus (MRSA) is important in infection control and surveillance. The current nomenclature of MRSA includes the genetic background of the S.
Hülya Kaya +9 more
doaj +1 more source
Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells
Stem Cell Research, 2014 The shortage of molecular information on cell cycle changes along embryonic stem cell (ESC) differentiation prompts an in silico approach, which may provide a novel way to identify candidate genes or mechanisms acting in coordinating the two programs. We
Angela Re +4 more
doaj +1 more source
Is the pan-genome also a pan-selectome? [v1; ref status: indexed, http://f1000r.es/Vl9wKI]
F1000Research, 2012 The comparative genomics of prokaryotes has shown the presence of conserved regions containing highly similar genes (the 'core genome') and other regions that vary in gene content (the ‘flexible’ regions).
Francisco Rodriguez-Valera +1 more
doaj +1 more source
ANALYZING THE GENOMIC VARIATION OF MICROBIAL CELL FACTORIES IN THE ERA OF “NEW BIOTECHNOLOGY”
Computational and Structural Biotechnology Journal, 2012 The application of genome-scale technologies, both experimental and in silico, to industrial biotechnology has allowed improving the conversion of biomass-derived feedstocks to chemicals, materials and fuels through microbial fermentation. In particular,
Markus Herrgård, Gianni Panagiotou
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Dissecting spatio‐temporal protein networks driving human heart development and related disorders
Molecular Systems Biology, 2010 Aberrant organ development is associated with a wide spectrum of disorders, from schizophrenia to congenital heart disease, but systems‐level insight into the underlying processes is very limited. Using heart morphogenesis as general model for dissecting
Kasper Lage +20 more
doaj +1 more source