Results 61 to 70 of about 4,751,605 (346)
Development of a Biocontained Toluene-Degrading Bacterium for Environmental Protection
Microbiology Spectrum, 2021 Biocontainment is a safeguard strategy for preventing uncontrolled proliferation of genetically engineered microorganisms (GEMs) in the environment. Biocontained GEMs are designed to survive only in the presence of a specific molecule.
Masahito Ishikawa +2 more
doaj +1 more source
Sequence modeling and design from molecular to genome scale with Evo
bioRxivThe genome is a sequence that completely encodes the DNA, RNA, and proteins that orchestrate the function of a whole organism. Advances in machine learning combined with massive datasets of whole genomes could enable a biological foundation model that ...
Eric Nguyen +15 more
semanticscholar +1 more source
Single-cell sequencing in stem cell biology
Genome Biology, 2016 Cell-to-cell variation and heterogeneity are fundamental and intrinsic characteristics of stem cell populations, but these differences are masked when bulk cells are used for omic analysis. Single-cell sequencing technologies serve as powerful tools to dissect cellular heterogeneity comprehensively and to identify distinct phenotypic cell types, even ...
Lu Wen, Fuchou Tang
openaire +3 more sources
Population Ecology, EarlyView.Population size and dynamics fundamentally shape speciation by influencing genetic drift, founder events, and adaptive potential. Small populations may speciate rapidly due to stronger drift, whereas large populations harbor more genetic diversity, which can alter divergence trajectories. We highlight theoretical models that incorporate population size
Ryo Yamaguchi +3 more
wiley +1 more source
Journal of Microbiology & Biology Education, 2017 Essential or enduring understandings are often defined as the underlying core concepts or “big ideas” we’d like our students to remember when much of the course content has been forgotten.
Pamela A. Marshall
doaj +1 more source
Synthetic biology open language (SBOL) version 3.0.0
Journal of Integrative Bioinformatics, 2020 Synthetic biology builds upon genetics, molecular biology, and metabolic engineering by applying engineering principles to the design of biological systems.
Baig Hasan +14 more
doaj +1 more source
Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk
Nature Genetics, 2018 Key challenges for human genetics, precision medicine and evolutionary biology include deciphering the regulatory code of gene expression and understanding the transcriptional effects of genome variation.
Jian Zhou +5 more
semanticscholar +1 more source
Skin microbiota in health and disease: From sequencing to biology [PDF]
The Journal of Dermatology, 2020 AbstractMicrobiota live in a closely regulated interaction with their environment, and vice versa. The presence and absence of microbial entities is greatly influenced by features of the niche in which they thrive. Characteristic of this phenomenon is that different human skin sites harbor niche‐specific communities of microbes.
Ederveen, T.H.A. +7 more
openaire +5 more sources
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
G-quadruplexes and their regulatory roles in biology
Nucleic Acids Research, 2015 ‘If G-quadruplexes form so readily in vitro, Nature will have found a way of using them in vivo’ (Statement by Aaron Klug over 30 years ago). During the last decade, four-stranded helical structures called G-quadruplex (or G4) have emerged from being a ...
D. Rhodes, H. Lipps
semanticscholar +1 more source