Results 91 to 100 of about 4,125,791 (291)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

A Deterministic Algorithm for Alpha-Numeric Sequence Comparison with Application to Protein Sequence Detection

Journal of Algorithms & Computational Technology, 2015
This paper is an extension of a deterministic algorithm, [1, 2], that was initially designed to measure the rate of similarity between DNA sequences, and any sequences made up with symbols of alphabets of cardinality 4.
A. Kheniche, N. Brahimi, A. Salhi
doaj   +1 more source

Shortfall Risk Approximations for American Options in the multidimensional Black--Scholes Model [PDF]

, 2010
We show that shortfall risks of American options in a sequence of multinomial approximations of the multidimensional Black--Scholes (BS) market converge to the corresponding quantities for similar American options in the multidimensional BS market with ...
Dolinsky, Yan
core  

The Ages of Pre-main-sequence Stars

, 1998
The position of pre-main-sequence or protostars in the Hertzsprung--Russell diagram is often used to determine their mass and age by comparison with pre-main-sequence evolution tracks.
Alexander, Anders, Baraffe, Bell, Boss, Carpenter, Christopher A. Tout, Cohen, D'Antona, Eggleton, Eggleton, Eggleton, Gullbring, Hartmann, Hartmann, Hayashi, Henyey, Hillenbrand, Ian A. Bonnell, Iglesias, Kenyon, Kenyon, Kroupa, Larson, Larson, Lin, Low, Mario Livio, Mercer-Smith, Muzerolle, Palla, Pols, Rees, Rubin, Siess, Siess, Stahler, Stahler, Stahler, Stahler, Stahler, Tout, Tout, Warner, Winkler, Woolley   +45 more
core   +2 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Comparison of sequence-dependent tiling array normalization approaches

BMC Bioinformatics, 2009
Background The detection of enriched DNA or RNA fragments by tiling microarrays has become more and more popular. These microarrays contain a high number of small probes covering genomic loci.
Vingron Martin, Chung Ho-Ryun
doaj   +1 more source

The NIST compilation of ionization potentials revisited (I): From He-like to Xe-like ions

, 2015
The National Institute of Standards and Technology (NIST) database on ionization potentials for neutral atoms and ions is examined. For each isoelectronic sequence, we construct a regularized perturbative series that exactly matches the large-$Z$ and $Z ...
Gil, Gabriel, Gonzalez, Augusto
core   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source