Results 201 to 210 of about 775,502 (352)

Amino Acid Sequence Homology and Modeling of Cysteine Protease Cathepsin S

Pakistan Journal of Biological Sciences, 2000
Rukhshan Khurshid, Asmat Saleem .
openaire   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

Isolation and expression of terminal flower1 (TFL1) gene in clove (Syzygium aromaticum L.). [PDF]

BMC Res Notes
Darwati I, Santoso TJ, Rachmat A, Sutanto A, Bermawie N, Sisharmini A, Suryadi R, Rusmin D, Trisilawati O, Garvita RV, Yusron M, Suryani S, Anggraeni T.   +12 more
europepmc   +1 more source

Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1

Advanced Science, EarlyView.
Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang, Yi Liu, Zhiying Yao, Haolong Lai, Xiaoxin Chen, Ziqiu Wang, Yiqiong Bao, Tingting Li, Xiaoming Zhou, Xiabin Chen, Peiguo Yang   +10 more
wiley   +1 more source

Protein language models uncover carbohydrate-active enzyme function in metagenomics. [PDF]

BMC Bioinformatics
Thurimella K, Mohamed AMT, Li C, Vatanen T, Graham DB, Owens RM, La Rosa SL, Plichta DR, Bacallado S, Xavier RJ.   +9 more
europepmc   +1 more source

Molecular cloning of complementary deoxyribonucleic acid for an androgen-regulated epididymal protein: sequence homology with metalloproteins.

Molecular Endocrinology, 1988
N. Charest, David R. Joseph, Elizabeth M. Wilson, Frank S. French   +3 more
semanticscholar   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Structome-AlignViewer: On Confidence Assessment in Structure-Aware Alignments. [PDF]

Genome Biol Evol
Malik AJ, Mao S, Hugenholtz P, Ascher DB.   +3 more
europepmc   +1 more source

A Reactive Antagonist Strategy: Cysteine‐Directed Covalent Molecular Glue in Plant Hormone Receptor Regulation

Advanced Science, EarlyView.
The plant hormone jasmonate is perceived by COI1‐JAZ co‐receptors comprising a single F‐box protein COI1 and multiple JAZ repressors with overlapping functions, complicating genetic analysis. We present a reactive antagonist (RA) strategy that selectively promotes COI1 binding to a cysteine‐engineered JAZ variant while blocking wild‐type JAZs, enabling
Minoru Ueda, Kotaro Matsumoto, Takao Nomura, Yousuke Takaoka, Taichi Okumura, Wataru Kozaki, Hikaru Hoshikawa, Yuho Nishizato, Andrea Chini, Roberto Solano, Katsumi Maenaka   +10 more
wiley   +1 more source

OrthoML2GO: homology-based protein function prediction using orthogroups and machine learning. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Malyugin EV, Afonnikov DA.
europepmc   +1 more source