Results 61 to 70 of about 775,502 (352)

Genetic variation in NSP4 of type 1 porcine reproductive and respiratory syndrome virus in China

BMC Veterinary Research
Background Porcine reproductive and respiratory syndrome virus (PRRSV) is characterized by a high mutation rate. Although research has largely focused on PRRSV-2, the detection rate of PRRSV-1 in China is increasing.
Huiyang Sha, Xiaolin Lan, Zhiyu Yang, Chen Lv, Hang Zhang, Qin Luo, Yajie Zheng, Gan Li, Weili Kong, Liangzong Huang, Jun Ma, Mengmeng Zhao   +11 more
doaj   +1 more source

Sensitive remote homology search by local alignment of small positional embeddings from protein language models

eLife
Accurately detecting distant evolutionary relationships between proteins remains an ongoing challenge in bioinformatics. Search methods based on primary sequence struggle to accurately detect homology between sequences with less than 20% amino acid ...
Sean R Johnson, Meghana Peshwa, Zhiyi Sun   +2 more
doaj   +1 more source

The nucleotide sequence of a human immnnoglobulin C-gamma-1 gene [PDF]

, 1982
We report the nucleotide sequence of a gene encoding the constant region of a human immnnoglobulin γ1 heavy chain (Cγ1). A comparison of this sequence with those of the Cγ2 and Cγ4 genes reveals that these three human Cγ genes share considerable homology
Berson, Bennett J., Ellison, Jay W., Hood, Leroy E.   +2 more
core  

Of bits and bugs [PDF]

, 2010
Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut, Kostrewa, Dirk, Niessing, Dierk, Roche, Stéphane, Söding, Johannes   +4 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Regional Differences in the Amino Acid Sequences of Fasciola hepatica Cathepsin L2 From a Turkish Isolate

Balkan Medical Journal, 2011
Objective: This study describes cloning and sequence analysis of the gene coding for the cathepsin L2 gene from a F. hepatica isolate from Turkey. Methods: The adult form of F.
Serpil Başpınar, Venhar Çelik, Dilek Turgut Balık, Mustafa Kaplan   +3 more
doaj  

Molecular cloning and expression analysis of a new stress-related AREB gene from Arachis hypogaea

Biologia Plantarum, 2013
An AREB gene, designated as AhAREB1, was cloned from peanut (Arachis hypogaea L.). The gene contains a 1 338-bp open reading frame that encodes a putative protein of 445 amino acids.
L. Hong, B. Hu, X. Liu, C. Y. He, Y. Yao, X. L. Li, L. Li   +6 more
doaj   +1 more source

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source