Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Genetic sex validation for sample tracking in next-generation sequencing clinical testing
BMC Research NotesObjective Data from DNA genotyping via a 96-SNP panel in a study of 25,015 clinical samples were utilized for quality control and tracking of sample identity in a clinical sequencing network.
Jianhong Hu +29 more
doaj +1 more source
GRIPT: a novel case-control analysis method for Mendelian disease gene discovery
Genome Biology, 2018 Despite rapid progress of next-generation sequencing (NGS) technologies, the disease-causing genes underpinning about half of all Mendelian diseases remain elusive.
Jun Wang +9 more
doaj +1 more source
On the Balancedness of M-Sequencing Games [PDF]
This paper studies m-sequencing games that arise from sequencing situations with m parallel and identical machines. These m-sequencing games, which involve n players, give rise to m-machine games, which involve m players.
Hamers, H.J.M., Klijn, F., Suijs, J.P.M.
core +1 more source
Improving nanopore read accuracy with the R2C2 method enables the sequencing of highly multiplexed full-length single-cell cDNA. [PDF]
, 2018 High-throughput short-read sequencing has revolutionized how transcriptomes are quantified and annotated. However, while Illumina short-read sequencers can be used to analyze entire transcriptomes down to the level of individual splicing events with ...
Byrne, Ashley +6 more
core +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Evaluation of recombination detection methods for viral sequencing [PDF]
, 2023 Frederick R. Jaya +2 more
openalex +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
On Games corresponding to Sequencing Situations with Precedence Relations [PDF]
In this paper we study a class of cooperative sequencing games that arise from one-machine sequencing situations in which chain precedence relations are imposed on the jobs. It is shown that these sequencing games are convex.cooperative games, sequencing
Bas van Velzen +2 more
core
Author Correction: Performance assessment of DNA sequencing platforms in the ABRF Next-Generation Sequencing Study [PDF]
, 2021 Jonathan Foox +26 more
openalex +1 more source