Results 21 to 30 of about 1,873,067 (319)

SVhound: detection of regions that harbor yet undetected structural variation

BMC Bioinformatics, 2023
Background Recent population studies are ever growing in number of samples to investigate the diversity of a population or species. These studies reveal new polymorphism that lead to important insights into the mechanisms of evolution, but are also ...
Luis F. Paulin, Muthuswamy Raveendran, R. Alan Harris, Jeffrey Rogers, Arndt von Haeseler, Fritz J. Sedlazeck   +5 more
doaj   +1 more source

From Information Overload to Actionable Insights: Digital Solutions for Interpreting Cancer Variants from Genomic Testing

Journal of Molecular Pathology, 2021
Given the increase in genomic testing in routine clinical use, there is a growing need for digital technology solutions to assist pathologists, oncologists, and researchers in translating variant calls into actionable knowledge to personalize patient ...
Stephanie J. Yaung, Adeline Pek
doaj   +1 more source

Novel characterization discoveries of ferroptosis-associated molecules in COAD microenvironment based TCGA data

Frontiers in Molecular Biosciences, 2022
Background and Objective: One of the most recent forms of programmed cell death, ferroptosis, is crucial in tumorigenesis. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the antioxidant system’s ...
Salem Baldi, Yun He, Igor Ivanov, Yaping Sun, Wei Feng, Moath Refat, Shadi A. D. Mohammed, Salah Adlat, Zixuan Tian, Yi Wang, Yaping Gao, Hui Tian   +11 more
doaj   +1 more source

High-throughput Quant-iT PicoGreen assay using an automated liquid handling system

BioTechniques, 2019
Workflows in NGS facilities require high-standard practices and high-throughput pipelines to process the large number of samples received in a timely manner. Downstream protocols such as NGS library preparation require accurate estimation of nucleic acid
Kay Anantanawat, Nicola Pitsch, Caroline Fromont, Caroline Janitz   +3 more
doaj   +1 more source

Sequencing chess [PDF]

EPL (Europhysics Letters), 2016
We analyze the structure of the state space of chess by means of transition path sampling Monte Carlo simulation. Based on the typical number of moves required to transpose a given configuration of chess pieces into another, we conclude that the state space consists of several pockets between which transitions are rare.
atashpendar, Arshia, Schilling, Tanja, Voigtmann, Thomas   +2 more
openaire   +3 more sources

Comparison of SARS-CoV-2 sequencing using the ONT GridION and the Illumina MiSeq

BMC Genomics, 2022
Background Over 4 million SARS-CoV-2 genomes have been sequenced globally in the past 2 years. This has been crucial in elucidating transmission chains within communities, the development of new diagnostic methods, vaccines, and antivirals.
Derek Tshiabuila, Jennifer Giandhari, Sureshnee Pillay, Upasana Ramphal, Yajna Ramphal, Arisha Maharaj, Ugochukwu Jacob Anyaneji, Yeshnee Naidoo, Houriiyah Tegally, Emmanuel James San, Eduan Wilkinson, Richard J. Lessells, Tulio de Oliveira   +12 more
doaj   +1 more source

Genomic targets for high-resolution inference of kinship, ancestry and disease susceptibility in orang-utans (genus: Pongo)

BMC Genomics, 2020
Background Orang-utans comprise three critically endangered species endemic to the islands of Borneo and Sumatra. Though whole-genome sequencing has recently accelerated our understanding of their evolutionary history, the costs of implementing routine ...
Graham L. Banes, Emily D. Fountain, Alyssa Karklus, Hao-Ming Huang, Nian-Hong Jang-Liaw, Daniel L. Burgess, Jennifer Wendt, Cynthia Moehlenkamp, George F. Mayhew   +8 more
doaj   +1 more source

Chimeric Phi29 DNA polymerase with helix–hairpin–helix motifs shows enhanced salt tolerance and replication performance

Microbial Biotechnology, 2021
Summary Phi29 DNA polymerase (Phi29 Pol) has been successfully applied in DNA nanoball‐based sequencing, real‐time DNA sequencing from single polymerase molecules and nanopore sequencing employing the sequencing by synthesis (SBS) method.
Yaping Gao, Yun He, Liyi Chen, Xing Liu, Igor Ivanov, Xuerui Yang, Hui Tian   +6 more
doaj   +1 more source

Biological and technical factors in the assessment of blood-based tumor mutational burden (bTMB) in patients with NSCLC

Journal for ImmunoTherapy of Cancer, 2022
Background Patients treated with immunotherapy are at risk of considerable adverse events, and the ongoing struggle is to accurately identify the subset of patients who will benefit.
Kim Monkhorst, Daniel Klass, Milou Schuurbiers, Zhongyun Huang, Senglor Saelee, Manana Javey, Leonie de Visser, Daan van den Broek, Michel van den Heuvel, Alexander F Lovejoy   +9 more
doaj   +1 more source

High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens

International Journal of Microbiology, 2022
Background. Antimicrobial resistance is limiting treatment options for Neisseria gonorrhoeae infections. To aid or replace culture and the syndromic management approach, molecular assays are required for antimicrobial susceptibility testing to guide ...
Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus, Koleka P. Mlisana   +10 more
doaj   +1 more source