Results 91 to 100 of about 448,986 (305)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On Higher-Order Sequential Fractional Differential Inclusions with Nonlocal Three-Point Boundary Conditions

Abstract and Applied Analysis, 2014
We study a nonlinear three-point boundary value problem of sequential fractional differential inclusions of order ξ+1 with n ...
Bashir Ahmad, Sotiris K. Ntouyas
doaj   +1 more source

SemSeq4FD: Integrating global semantic relationship and local sequential order to enhance text representation for fake news detection. [PDF]

Expert Syst Appl, 2021
Wang Y, Wang L, Yang Y, Lian T.
europepmc   +1 more source

The sequential order of instructions

Journal of Technical Writing and Communication, 1999
Document designers who present procedural instructions can choose several formats: prose, table, logical tree, or flow chart. In all cases, however, it is essential that the instructions are ordered in a way that allows users to reach the outcome in as little time as possible.
Jansen, C.J.M., Steehouder, M.F.
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Deterministic parallel execution Of sequential programs

, 1994
Parallel discrete event simulation (PDES) research has led to the development of distributed order preserving protocols. Generalization of these protocols offers the prospect of parallel and yet deterministic execution of sequential program.
S.C. Winter, Kalantery, N., D.R. Wilson, Winter, S., N. Kalantery, Wilson, D.R.   +5 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Methamphetamine abuse impairs sequential working memory

Frontiers in Psychiatry
The ability to maintain and manipulate sequential information in working memory, referred to as sequential working memory, plays a vital role in our daily life.
Wang Yao, Hao Zhang, Shuaiqi Li, Sensen Song, Zheng Ye, Xiaolin Zhou   +5 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source