Results 141 to 150 of about 10,678 (163)
AbstractThe expression of autophagy‐related markers has occasionally been reported to correlate with the clinical stage of disease in patients with solid cancer, indicating autophagy activation. However, there have been no such reports for cutaneous squamous cell carcinoma.
Nagisa Yoshihara, Takashi Ueno
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This study evaluated the protective role of p38 mitogen-activated protein kinase (p38 MAPK) inhibitors and sequestosome 1 (Sqstm1/A170/p62), a stress-induced signal modulator, in acoustic injury of the cochlea in mice. Two weeks after the exposure of mice to acoustic stress, threshold shifts of the auditory brainstem response (ABR) from the pre ...
Keiji Tabuchi +9 more
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Bacillus thuringiensis produces insecticidal crystal (Cry) proteins that target and destroy insect pest midgut epithelial cells, ultimately leading to larval death. However, exposure to sublethal concentrations of Cry proteins can activate defense responses to counteract toxicity.
Sirui Li +8 more
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AbstractPurpose The pathogenesis of AMD involves impaired protein degradation in RPE cells. The ubiquitin‐proteasome pathway and the lysosomal pathway including autophagy are the major proteolytic systems in eukaryotic cells. Recently, p62/sequestosome 1 (p62) has been shown to be a key player linking the proteasomal and lysosomal clearance systems. In
Johanna Viiri +3 more
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Frank M. LaFerla, Kara M. Neely
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Maurizio Molinari, Ilaria Fregno
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Veterinary Pathology, 2014
Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich +5 more
openaire +2 more sources
Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich +5 more
openaire +2 more sources
2022
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases, part of the motor neuron disease (MND) spectrum, that share genetic and pathologic features which lead to the rapid degeneration of motor neurons in the brain and spinal cord. Thus, at both a clinical and molecular level, patients may present with pure
openaire +1 more source
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases, part of the motor neuron disease (MND) spectrum, that share genetic and pathologic features which lead to the rapid degeneration of motor neurons in the brain and spinal cord. Thus, at both a clinical and molecular level, patients may present with pure
openaire +1 more source
Sequestosome 1 Is Part of the Interaction Network of VAPB
International Journal of Molecular Sciences, 2021Christina James +2 more
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