Results 141 to 150 of about 10,729 (166)
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The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer
Clinical and Translational Oncology, 2023Ovarian cancer (OC) is the most deadly tumor that may develop in a woman's reproductive system. It is also one of the most common causes of death among those who have been diagnosed with cancer in women. An adapter protein known as sequestosome 1(SQSTM1) or p62 is primarily responsible for the transportation, degradation, and destruction of a wide ...
Maryam Rabiei +1 more
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Sequestosome 1/p62: a multi-domain protein with multi-faceted functions
Frontiers in Biology, 2012The Sequestosome 1/p62 protein has been implicated in the regulation of a multitude of cellular processes such as NF-κB signaling, NRF2-driven oxidative stress response, protein turnover through the ubiquitin-proteasome pathway and the autophagosome/lysosome pathway, apoptosis and cellular metabolism.
Haining Zhu, József Gal, Zhu Haining
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Molecular and Cellular Neurosciences, 2005
The mechanisms implicated in the aggregation of ubiquitinated proteins detected in neurodegenerative disorders remain elusive. We report that prostaglandin J2 (PGJ2), an endogenous product of inflammation, up-regulates sequestosome 1/p62 in a time- and dose-dependent manner in human neuroblastoma SK-N-SH cells.
Maria Figueiredo-Pereira
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The mechanisms implicated in the aggregation of ubiquitinated proteins detected in neurodegenerative disorders remain elusive. We report that prostaglandin J2 (PGJ2), an endogenous product of inflammation, up-regulates sequestosome 1/p62 in a time- and dose-dependent manner in human neuroblastoma SK-N-SH cells.
Maria Figueiredo-Pereira
exaly +3 more sources
Journal of Dermatology, 2014
AbstractThe expression of autophagy‐related markers has occasionally been reported to correlate with the clinical stage of disease in patients with solid cancer, indicating autophagy activation. However, there have been no such reports for cutaneous squamous cell carcinoma.
Nagisa, Yoshihara +3 more
exaly +3 more sources
AbstractThe expression of autophagy‐related markers has occasionally been reported to correlate with the clinical stage of disease in patients with solid cancer, indicating autophagy activation. However, there have been no such reports for cutaneous squamous cell carcinoma.
Nagisa, Yoshihara +3 more
exaly +3 more sources
Veterinary Pathology, 2014
Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich +5 more
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Canine cutaneous mast cell tumors (MCT) are common, frequently malignant neoplasms that are currently graded histologically for provision of prognostic information. Continuing evidence of subsets of MCT within certain grades (with differing survival times) indicate the need for biomarkers that will facilitate better patient stratification and also ...
T, Rich +5 more
openaire +2 more sources
Neuroscience, 2010
This study evaluated the protective role of p38 mitogen-activated protein kinase (p38 MAPK) inhibitors and sequestosome 1 (Sqstm1/A170/p62), a stress-induced signal modulator, in acoustic injury of the cochlea in mice. Two weeks after the exposure of mice to acoustic stress, threshold shifts of the auditory brainstem response (ABR) from the pre ...
K, Tabuchi +9 more
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This study evaluated the protective role of p38 mitogen-activated protein kinase (p38 MAPK) inhibitors and sequestosome 1 (Sqstm1/A170/p62), a stress-induced signal modulator, in acoustic injury of the cochlea in mice. Two weeks after the exposure of mice to acoustic stress, threshold shifts of the auditory brainstem response (ABR) from the pre ...
K, Tabuchi +9 more
openaire +2 more sources
Journal of Agricultural and Food Chemistry
Bacillus thuringiensis produces insecticidal crystal (Cry) proteins that target and destroy insect pest midgut epithelial cells, ultimately leading to larval death. However, exposure to sublethal concentrations of Cry proteins can activate defense responses to counteract toxicity.
Sirui Li +8 more
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Bacillus thuringiensis produces insecticidal crystal (Cry) proteins that target and destroy insect pest midgut epithelial cells, ultimately leading to larval death. However, exposure to sublethal concentrations of Cry proteins can activate defense responses to counteract toxicity.
Sirui Li +8 more
openaire +2 more sources
Acta Ophthalmologica, 2012
AbstractPurpose The pathogenesis of AMD involves impaired protein degradation in RPE cells. The ubiquitin‐proteasome pathway and the lysosomal pathway including autophagy are the major proteolytic systems in eukaryotic cells. Recently, p62/sequestosome 1 (p62) has been shown to be a key player linking the proteasomal and lysosomal clearance systems. In
J VIIRI +3 more
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AbstractPurpose The pathogenesis of AMD involves impaired protein degradation in RPE cells. The ubiquitin‐proteasome pathway and the lysosomal pathway including autophagy are the major proteolytic systems in eukaryotic cells. Recently, p62/sequestosome 1 (p62) has been shown to be a key player linking the proteasomal and lysosomal clearance systems. In
J VIIRI +3 more
openaire +1 more source
Neuroscience Letters, 2017
Sequestosome 1 (SQSTM1) also known as ubiquitin-binding protein p62 (p62) is a cargo protein involved in the degradation of misfolded proteins via selective autophagy. Disruption of autophagy and resulting accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress.
Takashi, Tominaga +12 more
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Sequestosome 1 (SQSTM1) also known as ubiquitin-binding protein p62 (p62) is a cargo protein involved in the degradation of misfolded proteins via selective autophagy. Disruption of autophagy and resulting accumulation of misfolded proteins in the endoplasmic reticulum (ER) leads to ER stress.
Takashi, Tominaga +12 more
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2022
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases, part of the motor neuron disease (MND) spectrum, that share genetic and pathologic features which lead to the rapid degeneration of motor neurons in the brain and spinal cord. Thus, at both a clinical and molecular level, patients may present with pure
openaire +1 more source
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative diseases, part of the motor neuron disease (MND) spectrum, that share genetic and pathologic features which lead to the rapid degeneration of motor neurons in the brain and spinal cord. Thus, at both a clinical and molecular level, patients may present with pure
openaire +1 more source