Results 161 to 170 of about 3,647 (218)

Intrinsically dominant conformational diversity in PDZ1 within the tandem PDZ1–PDZ2 of human syntenin‐1 underlied by crystal structures

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The intrinsic dynamic asymmetry between homologous PDZ domains in multidomain scaffold proteins offers insight into how they achieve multivalent partner recognition. Through a systematic x‐ray crystallographic analysis of tandem PDZ1–PDZ2 domains in human syntenin‐1 (SDCBP/MDA‐9), we solved nine high‐resolution structures and uncovered ...
Natsuno Ando, Yuya Hanazono, Koya Sakuma, Nobutaka Numoto, Ryusei Hamajima, Takeshi Tenno, Atsunori Oshima, Nobutoshi Ito, Hidekazu Hiroaki   +8 more
wiley   +1 more source

Stabilizing Plasmodium falciparum proteins for small molecule drug discovery

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Early‐stage drug discovery relies on the availability of stable protein for reliable biophysical characterization of ligand binding. However, many Plasmodium falciparum proteins are challenging to produce in heterologous systems, which limits their experimental utility.
Marius Amann, Tim Sträßer, Oliver Einsle, Stefan Günther   +3 more
wiley   +1 more source

Use of biomolecular emulator for characterizing flexible proteins by small‐angle x‐ray scattering

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Flexible proteins populate heterogeneous conformational ensembles that are essential for their function. Small‐angle x‐ray scattering (SAXS) is widely used to study protein structure in solution and to characterize conformational heterogeneity.
Yoni Haitin, Bar Manori, Moshe Giladi
wiley   +1 more source

Structural Analysis and Inhibitor Modeling of Bacterioferritin From Brucella abortus

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1170-1181, June 2026.
ABSTRACT Iron homeostasis in various pathogenic bacteria is regulated by bacterioferritins (Bfr) which function to store Fe3+ and release Fe2+ as needed for metabolic processes. The Bfr structure consists of 18 kDa subunits in which dimer pairs bind a heme molecule and are assembled into a highly symmetrical 24‐meric spherical structure with an ...
Lijun Liu, Elizabeth K. Harmon, Justin K. Craig, Huili Yao, Kevin P. Battaile, David K. Johnson, Sandhya Subramanian, Wesley C. Van Voorhis, Mario Rivera, Scott Lovell   +9 more
wiley   +1 more source

Snapshots of Motion: A Novel Structural Intermediate Reveals Conserved Dynamics in Archaeal DNA Ligases

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 6, Page 1245-1258, June 2026.
ABSTRACT We present the first x‐ray crystallographic structural evidence of an archaeal DNA ligase showing the AMP covalent adduct together with further cofactor hydrolysis, capturing a transient intermediary in the first step of the ligation reaction, triggered by the pyrophosphate hydrolysis.
A. X. Quintana‐Armas, E. Flores‐Hernández, C. Cardona‐Félix, E. Rudiño‐Piñera   +3 more
wiley   +1 more source

Integrating simultaneous interfacial shear rheology with neutron reflectometry for structural and dynamic analysis of fluid interfacial systems

Journal of Applied Crystallography, Volume 59, Issue 3, Page 751-764, June 2026.
We present a new setup at the FIGARO horizontal neutron reflectometer enabling simultaneous measurement of the structural and mechanical properties of liquid interfaces, combining neutron reflectometry with interfacial shear rheology.The study of the structure and mechanical properties of complex fluid interfaces has attracted growing interest in ...
Pablo Sánchez-Puga, Javier Tajuelo, Javier Carrascosa-Tejedor, Miguel Ángel Rubio, Philipp Gutfreund, Armando Maestro   +5 more
wiley   +1 more source

indexGIXS: software for visualizing and interactive indexing of grazing‐incidence scattering data

Journal of Applied Crystallography, Volume 59, Issue 3, Page 960-967, June 2026.
A program is described for visualizing grazing‐incidence scattering data and interactive indexing of the observed diffraction spots.Grazing‐incidence small‐ and wide‐angle X‐ray scattering are widely applied for the study of functional organic thin films, be it for the characterization of nanostructured morphologies in block copolymers, nanocomposites ...
Detlef-M. Smilgies, Ruipeng Li
wiley   +1 more source

50th anniversary of the Stanford SSRL synchrotron radiation and protein crystallography initiative. [PDF]

J Synchrotron Radiat
Helliwell JR, Nave C, Szebenyi DM.
europepmc   +1 more source

Automated serial electron diffraction: implementation in LibraEDT and its applications

Journal of Applied Crystallography, Volume 59, Issue 3, Page 858-868, June 2026.
We describe a continuous serial electron diffraction implementation in LibraEDT that enables automated data collection with real‐time frame evaluation, together with an accessible workflow for subsequent data processing.Serial electron diffraction (SerialED) offers an effective route for structure determination of beam‐sensitive materials, yet its ...
Moussa D. Faye Diouf, Danilo Marchetti, Paola Parlanti, Alessandro Pedrini, Mauro Gemmi   +4 more
wiley   +1 more source

Pinpointing Protein Crystal Structures over a Broad Temperature Range Using Hydrophobic Protection. [PDF]

ACS Omega
Ribeiro FS, Lima LMTR.
europepmc   +1 more source