Results 261 to 270 of about 951,429 (338)

Serine Biosynthesis in Rat Liver

open access: hybrid, 1966
Harold J. Fallon   +2 more
openalex   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

open access: yesAdvanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu   +18 more
wiley   +1 more source

Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment. [PDF]

open access: yesNat Commun
Aviles-Huerta D   +20 more
europepmc   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

open access: yesAdvanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo   +15 more
wiley   +1 more source

Purification and Properties of d-Serine Dehydrase from Escherichia coli

open access: hybrid, 1966
Daniel Dupourque   +2 more
openalex   +1 more source

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