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Spatial metabolomics as a new avenue in plant developmental biology: insights into serine biosynthesis during spermatogenesis in <i><b>Marchantia polymorpha</b></i>. [PDF]
Plant Signal BehavTabeta H, Uzaki M, Hirai MY.
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Mechanism of eukaryotic serine racemase-catalyzed serine dehydration
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020Eukaryotic serine racemase (SR) is a pyridoxal 5'-phosphate enzyme belonging to the Fold-type II group, which catalyzes serine racemization and is responsible for the synthesis of D-Ser, a co-agonist of the N-methyl-d-aspartate receptor. In addition to racemization, SR catalyzes the dehydration of D- and L-Ser to pyruvate and ammonia.
Tomokazu, Ito +8 more
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Serine hydroxymethyltransferase revisited
Current Opinion in Chemical Biology, 2005Recent structural data and the properties of several active site mutants of serine hydroxymethyltransferase have resolved some key questions concerning the catalytic mechanism and broad substrate specificity of this enzyme. In the tetrahydrofolate-dependent conversion of serine to glycine, an early proposed mechanism involved a retroaldol cleavage and ...
Verne, Schirch, Doletha Me, Szebenyi
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Current Opinion in Neurology, 2004
Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J, de Koning, Leo W J, Klomp
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Serine-deficiency disorders comprise a new group of neurometabolic diseases and are caused by defects in the biosynthesis of the amino acid L-serine. In contrast to most neurometabolic disorders, serine-deficiency disorders are potentially treatable. Furthermore, the severe neurological symptoms observed in patients underscore the important roles of ...
Tom J, de Koning, Leo W J, Klomp
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Current Opinion in Clinical Nutrition and Metabolic Care, 2013
Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky +2 more
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Here, we discuss the recent data on the role of different N-methyl D-aspartate receptor (NMDAR) coagonists, D-serine and glycine, in regulating NMDAR activity and neurotoxicity.D-Serine originates from both neurons and astrocytes, from where it is released by different mechanisms.
Inna, Radzishevsky +2 more
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Synthesis of photodeprotectable serine derivatives. “Caged serine”
Bioorganic & Medicinal Chemistry Letters, 1992Abstract The synthesis of O-(4,5-dimethoxy-2-nitrobenzyl)serine has been accomplished by treatment of an FMOC-aziridinecarboxylate with nitroveratryl alcohol followed by hydrolysis. Irradiation with a Pyrex-filtered 450W Hanovia lamp releases serine with a half-life of 4.4 min. o-Nitrobenzyl serinate is prepared by direct esterification.
Michael C. Pirrung, David S. Nunn
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