Results 21 to 30 of about 265,113 (235)

Efficient Hydrolysis of Gluten-Derived Celiac Disease-Triggering Immunogenic Peptides by a Bacterial Serine Protease from Burkholderia gladioli

Biomolecules, 2021
Celiac disease is an autoimmune disorder triggered by toxic peptides derived from incompletely digested glutens in the stomach. Peptidases that can digest the toxic peptides may formulate an oral enzyme therapy to improve the patients’ health condition ...
Yu-You Liu, Cheng-Cheng Lee, Jun-Hao Hsu, Wei-Ming Leu, Menghsiao Meng   +4 more
doaj   +2 more sources

Microcystin-LR-Induced Oxidative Stress, Transcriptome Changes, Intestinal Microbiota, and Histopathology in Rana chensinensis Tadpoles [PDF]

Animals
Microcystin-LR (MC-LR), produced by Cyanobacteria, is being detected in many types of waters, posing a universal threat to aquatic animals. However, there have been few comprehensive endpoints assessed, including oxidative stress, transcriptome changes ...
You Wang, Bingjie Wang, Zhuolin He, Jiaxin Chen, Chenyang Liu, Zhanqi Wang, Muhammad Irfan, Lixia Zhang   +7 more
doaj   +2 more sources

Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. [PDF]

Fly (Austin), 2011
Chen S, Yang H, Krinsky BH, Zhang A, Long M.   +4 more
europepmc   +2 more sources

Structural basis for dimerization, catalytic regulation, and substrate selectivity of the chloroplast S9D CGEP protease in Arabidopsis thaliana. [PDF]

Protein Sci
Abstract S9 proteases are widely distributed across the tree‐of‐life and play essential roles in protein processing. However, the structural and mechanistic basis for protease activity in the S9D subfamily, restricted to photosynthetic eukaryotes (e.g., plants), cyanobacteria, proteobacteria and flavobacteria, is unknown. Here, we report the first high‐
Ehrlich JJ, Routray P, Enns L, van Wijk KJ, Kawate T.   +4 more
europepmc   +2 more sources

Quantitative Metaproteomics and Activity-based Protein Profiling of Patient Fecal Microbiome Identifies Host and Microbial Serine-type Endopeptidase Activity Associated With Ulcerative Colitis

Molecular & Cellular Proteomics, 2022
The gut microbiota plays an important yet incompletely understood role in the induction and propagation of ulcerative colitis (UC). Organism-level efforts to identify UC-associated microbes have revealed the importance of community structure, but less is
Peter S. Thuy-Boun, Ana Y. Wang, A. Crissien-Martinez, Janice H. Xu, Sandip Chatterjee, Gregory S. Stupp, A. Su, Walter Coyle, D. Wolan   +8 more
semanticscholar   +1 more source

Self Purification of Two Serine Endopeptidases [PDF]

Proceedings of the National Academy of Sciences, 1972
We have reported that a serine protease from Pronase, homologous with bovine chymotrypsin, is both active and stable in 6 M guanidinium chloride. The present investigation examined the possibility that this unique property might be used to permit the enzyme to engage in its own purification by cleaving companion proteins to low-molecular ...
W M, Awad, M S, Ochoa, T P, Toomey
openaire   +2 more sources

Safety evaluation of the food enzyme subtilisin from the non‐genetically modified Bacillus paralicheniformis strain LMG S‐30155

EFSA Journal, 2023
The food enzyme subtilisin (serine endopeptidase, EC 3.4.21.62) is produced with the non‐genetically modified microorganism Bacillus paralicheniformis strain LMG S‐30155 by ENMEX SA de CV, now part of Kerry Food Ingredients (Cork) Ltd. The food enzyme is
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Claude Lambré, José Manuel Barat Baviera, Claudia Bolognesi, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Marcel Mengelers, Alicja Mortensen, Gilles Rivière, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Lieve Herman, Yrjö Roos, Magdalena Andryszkiewicz, Cristina Fernàndez‐Fraguas, Yi Liu, Silvia Peluso, Andrew Chesson   +23 more
doaj   +1 more source

Crystal structures of trypanosoma brucei oligopeptidase B broaden the paradigm of catalytic regulation in prolyl oligopeptidase family enzymes [PDF]

, 2013
Oligopeptidase B cleaves after basic amino acids in peptides up to 30 residues. As a virulence factor in bacteria and trypanosomatid pathogens that is absent in higher eukaryotes, this is a promising drug target.
Canning, Peter, Fülöp, Vilmos, Morty, Rory E., Rea, Dean   +3 more
core   +6 more sources

Identification and characterization of fusolisin, the Fusobacterium nucleatum autotransporter serine protease. [PDF]

PLoS ONE, 2014
Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. A serine endopeptidase of 61-65 kDa capable of damaging host tissue and of inactivating immune effectors was detected ...
Lior Doron, Shunit Coppenhagen-Glazer, Yara Ibrahim, Amir Eini, Ronit Naor, Graciela Rosen, Gilad Bachrach   +6 more
doaj   +1 more source

Comparative Transcriptome Analysis Reveals the Adaptation Mechanism to High Salinity in Litopenaeus vannamei

Frontiers in Marine Science, 2022
As an euryhaline commercial species, the Pacific white shrimp Litopenaeus vannamei can be cultured under a wide range of salinities. However, different families showed various tolerance to high salinity. In order to elucidate the underlying mechanisms, a
Zheng Luo, Zheng Luo, Yang Yu, Yang Yu, Qian Zhang, Zhenning Bao, Zhenning Bao, Jianhai Xiang, Fuhua Li, Fuhua Li, Fuhua Li, Fuhua Li   +11 more
doaj   +1 more source