Results 101 to 110 of about 185,677 (239)

Influence of the activation status and of ATP on phosphoribulokinase degradation [PDF]

, 2017
The light-regulated choroplast enzyme phosphoribulokinase (EC 2.7.1. 19) exists in two forms. In darkness this enzyme is present in an oxidized form, which is inactive. It is activated in the light by a thioredoxin-mediated reduction.
Feller, Urs, Kamber, Lea
core  

Experimental application of sum rules for electron energy loss magnetic chiral dichroism [PDF]

, 2007
We present a derivation of the orbital and spin sum rules for magnetic circular dichroic spectra measured by electron energy loss spectroscopy in a transmission electron microscope. These sum rules are obtained from the differential cross section calculated for symmetric positions in the diffraction pattern.
arxiv   +1 more source

Contributions of Genetic Variation in Astrocytes to Cell and Molecular Mechanisms of Risk and Resilience to Late‐Onset Alzheimer's Disease

Glia, Volume 73, Issue 6, Page 1166-1187, June 2025.
Main Points Generation and characterization of iPSC‐derived astrocytes from 44 aged humans. Congruence of gene expression profiles between astrocyte cultures and brain. Association of interferon response proteins with AD pathology resilience. ABSTRACT Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants
Hyo Lee, Richard V. Pearse II, Alexandra M. Lish, Cheryl Pan, Zachary M. Augur, Gizem Terzioglu, Pallavi Gaur, Meichen Liao, Masashi Fujita, Earvin S. Tio, Duc M. Duong, Daniel Felsky, Nicholas T. Seyfried, Vilas Menon, David A. Bennett, Philip L. De Jager, Tracy L. Young‐Pearse   +16 more
wiley   +1 more source

Preascitic Sodium Retention in Cirrhosis: A Role for Disregulated Proteolysis by Proprotein Convertases?

Liver International Communications, Volume 6, Issue 2, June 2025.
ABSTRACT Loss of effective arterial blood volume, secondary hyperaldosteronism, adrenergic activation and nonosmotic hypersecretion of vasopressin induce sodium and water retention in cirrhotic patients with ascites. The mechanisms of sodium retention that precede ascites formation remain elusive.
Giovanni Sansoè, Manuela Aragno, Florence Wong   +2 more
wiley   +1 more source

The mycotoxin Beauvericin is an uncompetitive inhibitor of Cathepsin B

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Beauvericin (BEA), a cyclic depsipeptide, is a mycotoxin of the enniatin family and the secondary metabolite of various toxigenic fungi. Multiple biological functions of BEA have been well investigated, such as anti‐cancer, anti‐inflammatory, anti‐microbial, and immune‐activating functions. In a recent study, we showed that BEA can target Toll‐
Xiaoli Yang, Pablo Cea‐Medina, Mohanraj Gopalswamy, Aparna Vaidya, Sonja Schavier, Shixin Oltzen, Sofie Moßner, Anfei Huang, Jing Qi, Johanna Maria Hölken, Nicole Teusch, Doreen M. Floss, Markus Uhrberg, Holger Gohlke, Stefanie Scheu   +14 more
wiley   +1 more source

FunClust: a web server for the identification of structural motifs in a set of non-homologous protein structures [PDF]

, 2008
The occurrence of very similar structural motifs brought about by different parts of non homologous proteins is often indicative of a common function. Indeed, relatively small local structures can mediate binding to a common partner, be it a protein, a ...
A Henschel, A Stark, A Via, AC Wallace, AD Hill, Allegra Via, Anna Tramontano, CT Porter, F Ferre, G Ausiello, G Ausiello, Gabriele Ausiello, GK Sandve, GR Stockwell, HM Berman, KA Denessiouk, LH Greene, M Novotny, M Shatsky, M Shatsky, Manuela Helmer-Citterich, N Hulo, P Puntervoll, P. Marcatili, Paolo Marcatili, PF Gherardini, Pier Federico Gherardini, S Jones, SL Moodie   +28 more
core   +4 more sources

Genetic and transcriptomic analysis of lentil seed imbibition and dormancy in relation to its domestication

The Plant Genome, Volume 18, Issue 2, June 2025.
Abstract Seed dormancy is an adaptation that delays germination to prevent the start of this process during unsuitable conditions. It is crucial in wild species but its loss was selected during crop domestication to ensure a fast and uniform germination. Water uptake, or imbibition, is the first step of germination.
Azalea Guerra‐García, Jana Balarynová, Petr Smykal, Eric J von Wettberg, Scott D. Noble, Kirstin E. Bett   +5 more
wiley   +1 more source

Synthetic Lethality of the lytE cwlO Genotype in Bacillus subtilis Is Caused by Lack of D,L-Endopeptidase Activity at the Lateral Cell Wall [PDF]

, 2012
Bacterial peptidoglycan acts as an exoskeleton to protect the bacterial cell. Although peptidoglycan biosynthesis by penicillin-binding proteins is well studied, few studies have described peptidoglycan disassembly, which is necessary for a dynamic ...
Hashimoto, Masayuki, Ooiwa, Seika, Sekiguchi, Junichi   +2 more
core   +1 more source

Serine Proteases: an Ab Initio Molecular Dynamics Study [PDF]

arXiv, 1999
In serine proteases (SP's), the H-bond between His-57 and Asp-102, and that between Gly-193 and the transition state intermediate play a crucial role for enzymatic function. To shed light on the nature of these interactions, we have carried out ab initio molecular dynamics simulations on complexes representing adducts between the reaction intermediate ...
arxiv  

Simplex and multiplex CRISPR/Cas9‐mediated knockout of grain protease inhibitors in model and commercial barley improves hydrolysis of barley and soy storage proteins

Plant Biotechnology Journal, Volume 23, Issue 6, Page 2418-2428, June 2025.
Summary Anti‐nutritional factors in plant seeds diminish the utilization of nutrients in feed and food. Among these, protease inhibitors inhibit protein degradation by exogenous proteases during digestion. Through conventional and selection‐gene‐free genome editing using ovules as explants, we used simplex and multiplex CRISPR/Cas9 for studying the ...
Michael Panting, Inger B. Holme, Giuseppe Dionisio, Henrik Brinch‐Pedersen   +3 more
wiley   +1 more source