Results 81 to 90 of about 16,013 (203)

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, Volume 49, Issue 7, Page 3500-3517, July 2026.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

Characterization of endopeptidases from the midgut of Morimus funereus (Coleoptera: Cerambycidae) larvae

, 2014
— Application of specific chromogenic substrates, use of class-specific inhibitors, and zymogram analysis enabled us to identify several peptidase classes in extracts of the midgut of Morimus funereus larvae. Zymogram analysis with gelatin as a peptidase
Nataša Božić, Vera Nenadović, Biljana Dojnov, Jelisaveta Ivanović, Ra Milovanović, Z. Vujčić   +5 more
core  

Clostripain: Characterization of the active site

, 1991
In view of the probability that clostripain (EC 3,4,22.8) is fundamentally different in structure from other known cysteine endopeptidases. It was of interest to examine the characteristics of the active site Z-Pho-Lys-CH2S(CH3)2 irreversibly and rapidly
Peter Rauber, Ashu A. Kembhavi, Alan J. Barrett, Buttle, David J., David J. Buttle, Rauber, Peter, Kembhavi, Ashu A., Barrett, Alan J.   +7 more
core   +1 more source

Methodological Evaluation of Carbapenemase Detection by Different Methods

Polish Journal of Microbiology
The global proliferation of carbapenemase-producing bacteria (CPB) has garnered significant attention worldwide. Early diagnosis of CPB and accurate identification of carbapenemases are crucial for preventing the spread of CPB and ensuring targeted ...
Gao Nana, Zhou Jing, Li Ge, Liu Runde, Lu Guoping, Shen Jilu   +5 more
doaj   +1 more source

Racemisation of Amino Acids: From Synthetic Challenge to Biological Significance

ChemBioChem, Volume 27, Issue 11, 15 June 2026.
Racemisation, once considered an undesirable synthetic side reaction, also occurs naturally in amino acids and influences biological processes. Evidence links stereochemical conversion to ageing, protein turnover, and cellular development. This review examines mechanisms, control strategies in synthesis, applications and implications in physiology ...
Othman Al Musaimi
wiley   +1 more source

Macrocyclic Inhibitors of HGF-Activating Serine Proteases Overcome Resistance to Receptor Tyrosine Kinase Inhibitors and Block Lung Cancer Progression

Hepatocyte growth factor (HGF), the ligand for the MET receptor tyrosine kinase, is a tumor-promoting factor that is abundant in the tumor microenvironment. Proteolytic activation of inactive pro-HGF by one or more of the serine endopeptidases matriptase,
Tina Primeau (6718994), Vishnu C. Damalanka (1403389), Lidija Klampfer (245404), Jorine J. L. P. Voss (11832145), James W. Janetka (1386372), Matthew W. Mahoney (2272336), Shunqiang Li (1349001)   +6 more
core   +2 more sources

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, Volume 13, Issue 33, 15 June 2026.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Discovery of an Adaptive Neuroimmune Response Driving Itch and Fast Tick Removal with Implications for Preventing Pathogen Transmission

Advanced Science, Volume 13, Issue 32, 9 June 2026.
Itch‐induced tick removal (IITR): An acquired neuroimmune mechanism, itch‐induced tick removal, develops after repeated tick exposure, mobilizing T cells and macrophages at the tick bite site to trigger a rapid scratching response that facilitates timely tick removal within a critical window that precedes the transmission of many tick‐borne pathogens ...
Johannes S. P. Doehl, Tiago D. Serafim, Serena Doh, Charles S. Grugan, Eva Iniguez, Luana Rogerio, Ronja Frigard, Ranadhir Dey, Pedro Cecilio, Xinglong Gu, Pang‐Yen Tseng, Aline da Silva Moreira, Mahnaz Minai, James Oristian, Hans Ackerman, Steven Brooks, Caroline Percopo, Siu‐Ping Ng, Derron A. Alves, Lucas Tirloni, Jennifer M. Anderson, Adriana Marques, Fabiano Oliveira, Shaden Kamhawi, Daniel E. Sonenshine, José M. C. Ribeiro, Mark Hoon, Jesus G. Valenzuela   +27 more
wiley   +1 more source

Four spatial points that define enzyme families

, 2009
The catalytic properties of enzymes, containing the Asp-His-Ser triads are deeply investigated for a long time. Serine endopeptidases, cutinases, acetylcholinesterases, cellulases, among other enzymes, contain these triads.
Iván, Gábor, Náray-Szabó, Gábor, Grolmusz, Vince, Ördög, Rafael, Szabadka, Zoltán   +4 more
core   +1 more source

Artificial Sweeteners and Autoimmune Diseases: Insights From Integrative Bioinformatics and Mendelian Randomization

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
This study provides a novel molecular perspective on the role of AS in ADs development. We identified a positive association between artificially sweetened cereal intake and ADs risk and revealed multiple pathogenic mechanisms involving apoptosis, inflammatory signaling, immune activation, and gut microbiota dysbiosis.
Yupei Liu, Jizhen Huang, Xue Hu, Shan Tian, Jiao Li, Shiyun Tan, Weiguo Dong   +6 more
wiley   +1 more source