Results 101 to 110 of about 20,933 (225)

Fibroblast Activation Protein Promotes Thoracic Aortic Dissection via PLAUR/ITGB1‐Mediated Pro‐inflammatory Macrophage Polarization

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This study reveals that FAP promotes thoracic aortic dissection (TAD) through a nonenzymatic mechanism involving fibroblast‐macrophage crosstalk via the FAP/PLAUR/ITGB1/FAK axis. Targeting this pathway might offer a promising therapeutic strategy for TAD.
Hongqiao Zhu, Jianlie Wu, Ziyi Xu, Yifei Pei, Zaiping Jing, Jian Zhou, Rui Feng, Junjun Liu   +7 more
wiley   +1 more source

Self‐Adaptive Allantoin@ZIF8 Nanocomposite Hydrogel with Resveratrol Synergy for MRSA‐Infected Wound Regeneration

Advanced Science, Volume 13, Issue 21, 13 April 2026.
Based on allantoin‐loaded ZIF8 nanoparticles (Alla@ZIF8) and methacrylated quaternary ammonium carboxymethyl chitosan/resveratrol composite hydrogels (RMQCC), an adaptive multifunctional hydrogel system (Alla@ZIF8‐Gel) was constructed and confirmed to induce the healing of MRSA‐infected wounds via suppressing bacterial proliferation, alleviating ...
Yongjie Zhu, Dun Liu, Mengran Zhao, Xinyi Jian, Enuo Peng, Xingping Zhao, Zezhang Zhu, Bolin Tang, Benlong Shi   +8 more
wiley   +1 more source

Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity : a review [PDF]

, 2017
Ticks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous arthropods considered vectors of human infectious diseases. While consuming blood to obtain the nutrients necessary to carry on life functions, these insects can ...
A Ali, A Borges-Veloso, A Estrela, A Fontaine, A Mulenga, A Mulenga, A Mulenga, A Santos, A Schwarz, A Seixas, A Seixas, AA Rascón, AB Estrela, AC Bahia, AC Barnard, AF Rowley, AH Kollien, AL Williamson, AR Khan, AS Raikhel, AV Graça-Souza, BM Christensen, C Balczun, C Barillas-Mury, C Gaboriaud, C Logullo, Carla Nunes de Araújo, CC Hsu, CC Hsu, CE Cruz, CH Kim, CN Araújo de, CV Barillas-Mury, D Boldbaatar, D Borovsky, D Feder, D Feder, D Sojka, D Sojka, D Sojka, D Sojka, D Sojka, D Sojka, D Sojka, D Trevisan-Silva, DE Sonenshine, DP Oldiges, DS Buarque, DS Silva da, E Calvo, E Calvo, E Calvo, E Faudry, E Goulielmaki, EC Borges, EL Telleria, EL Telleria, ES Garcia, FA Lara, FG Noriega, FG Noriega, FG Noriega, FL Watson, Flávia Nader Motta, G Bian, G Dias-Lopes, G Renard, G Renard, G Ribeiro, GM Attardo, GR Garcia, H Mehlhorn, HM Müller, HM Müller, IM Francischetti, IM Francischetti, Izabela M. Dourado Bastos, J Chmelar, J Chmelař, J Isoe, J Kotál, J Leyria, J Mendiola, J Rivera, J Vizioli, Jaime M. Santana, JAT Dow, JG Houseman, JM Anderson, JM Ramalho-Ortigão, JM Ribeiro, JM Ribeiro, JM Ribeiro, JM Ribeiro, JM Ribeiro, JM Ribeiro, JMC Ribeiro, JMC Ribeiro, K Uchida, K Yamaji, KA Edgar, L Cerenius, L Cerenius, L Feitosa, L Gupta, L Liu, L Saboia-Vahia, LA Abreu, Lehane, LM Liu, M Abdul Alim, M Delcroix, M Horn, M Kazimírová, M Lehane, M Motobu, MA Alim, MA Alim, MC Brandon, MH Castro de, MH Sorgine, MJ Gorman, MJ Gorman, N Ruttayaporn, ND Rawlings, ND Rawlings, O Hajdušek, P Bork, P Sriwichai, Paula Beatriz Santiago, PB Santiago, PF Pimenta, PJ Waniek, PM Moolhuijzen, Q Jiang, R Amino, R Graf, R Graf, RB Silveira da, RB Silveira da, RW Almeida de, S Imamura, S Karim, S Tsakas, SA Armitage, Sébastien Charneau, T Hatta, T Lopez-Ordoñez, T Masaki, T Miyoshi, T Miyoshi, T Miyoshi, T Okamoto, T Okamoto, TC Assumpção, TC Assumpção, TC Assumpção, TF Huang, V Urbanová, WL Cho, WL Cho, World Health Organization, X Guo, X Nirmala, X Yu, XL Xu, Y Decrem, Y Dong, Y Schlein, Yanna Reis Praça, Z Franta, Z Franta, Z Shen, Ž Radulović   +173 more
core   +2 more sources

A Synthetic Study and Preliminary Evaluation of a Protease-Activated Doxazolidine Prodrug [PDF]

, 2012
Described are studies focused on prodrug delivery of a doxorubicin-formaldehyde conjugate, doxazolidine (Doxaz). Designed for targeted activation by the serine protease plasmin, Protease-Activated Doxazolidine (PAD) embodies a new approach to selective ...
Colvin, Sean
core   +2 more sources

Antimicrobial Peptides and Systemic Inflammation: A Network Analysis

Immunity, Inflammation and Disease, Volume 14, Issue 4, April 2026.
ABSTRACT Introduction Antimicrobial peptides (AMPs) are essential components of the innate immune system, exhibiting diverse mechanisms of action. Objective This study investigates the roles of cathelicidin (LL‐37), alpha‐defensins, and the S100 proteins S100A8 and S100A9 in systemic inflammation associated with sepsis, severe COVID‐19, and acute ...
Fabiano Pinheiro da Silva, Francisco Garcia Soriano, Ludhmila Abrahão Hajjar   +2 more
wiley   +1 more source

Hyaluronic Acid Decoration Facilitates CD44‐Mediated Targeting and Alters Protein Corona Formation of Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 4, April 2026.
ABSTRACT Cell recognition and uptake of extracellular vesicles (EVs) is mediated by a variety of surface molecules. Growing interest has recently been drawn towards glycan structures on EVs. Hyaluronic acid (HA) is a negatively charged glycosaminoglycan that can decorate the surface of EVs from different origins.
Heikki Kyykallio, Elena Scurti, Martina Hanzlíková, Kirsti Härkönen, Tuovi Salo, Veera Keinonen, Janne Capra, Tapani Viitala, Jaakko Teppo, Tatu Lajunen, Kirsi Rilla   +10 more
wiley   +1 more source

Crystal Structure of Crataeva tapia Bark Protein (CrataBL) and Its Effect in Human Prostate Cancer Cell Lines

, 2013
A protein isolated from the bark of Crataeva tapia (CrataBL) is both a Kunitz-type plant protease inhibitor and a lectin. We have determined the amino acid sequence and three-dimensional structure of CrataBL, as well as characterized its selected ...
Bertolin, T., Cabral Silva, M., dos Santos Correia, M., Ferreira, J., Ferreira, R., Guedes Paiva, P., Gustchina, A., Mentele, R., Paredes-Gamero, E., Silva-Lucca, R., Vilela Oliva, M., Wlodawer, A., Zhou, D.   +12 more
core   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

Tetraopes Milkweed Beetle Genomes Elucidate the Adaptive Basis of a Temperate Coevolutionary Radiation

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT The coevolutionary radiation of 27 species of Tetraopes longhorned beetles and their Asclepias milkweed hosts represents a classic example of adaptive evolution driven by plant chemical defences and herbivore counteradaptations. Investigations to date, however, have focused on a single species, Tetraopes tetrophthalmus, which feeds on the ...
Sangil Kim, Brian D. Farrell
wiley   +1 more source

Cloning, sequencing and extracellular expression of the alkaline protease gene from Bacillus stearothermophilus F1 [PDF]

, 2001
The gene of a highly thermostable alkaline protease was amplified from Bacillus stearothermophilus F1 by polymerase chain reaction using consensus primers based on the sequences of serine protease genes from related species.
Fu, Zhibiao
core