Results 51 to 60 of about 6,315 (155)
Critical involvement of the ATM-dependent DNA damage response in the apoptotic demise of HIV-1-elicited syncytia. [PDF]
PLoS ONE, 2008 DNA damage can activate the oncosuppressor protein ataxia telangiectasia mutated (ATM), which phosphorylates the histone H2AX within characteristic DNA damage foci.
Jean-Luc Perfettini +20 more
doaj +1 more source
Mathematical modelling of serine integrase - mediated gene assembly [PDF]
, 2018 Abstract Site-specific recombination promoted by serine integrases can be used for ordered assembly of DNA fragments into larger arrays. When a plasmid vector is included in the assembly, the circular product DNA molecules can transform E. coli cells.
Pokhilko, Alexandra +3 more
openaire +1 more source
The catalytic residues of Tn3 resolvase [PDF]
, 2009 To characterize the residues that participate in the catalysis of DNA cleavage and rejoining by the site-specific recombinase Tn3 resolvase, we mutated conserved polar or charged residues in the catalytic domain of an activated resolvase variant.
Olorunniji, F.J. +5 more
core +1 more source
Variable orthogonality of RDF – large serine integrase interactions within the ϕC31 family
Abstract Large serine integrases are phage- (or mobile element-) encoded enzymes that catalyse site-specific recombination reactions between a short DNA sequence on the phage genome ( attP ) and a corresponding host genome sequence ( attB ...
MacDonald AI +6 more
europepmc +3 more sources
Adaptation of the invasive pest Drosophila suzukii to a specialized nutritional niche
Insect Science, EarlyView.Unlike most Drosophila larvae that feed on spoiled food, Drosophila suzukii larvae thrive on ripening fruits and consequently face a low‐protein, high‐carbohydrate nutritional challenge. Comparisons of growth among D. suzukii, D. biarmipes, and D. melanogaster larvae across diets with varying protein‐to‐carbohydrate ratios demonstrate that D.
Yan Hou, Ying Zhen
wiley +1 more source
Mutational analysis of PhiC31 integrase to improve gene therapeutic applications [PDF]
, 2010 Die Bakteriophagen Integrase PhiC31 stellt ein viel versprechendes Werkzeug zur Integration genetischen Materials im nicht viral-basierten Gentransfer dar.
Liesner, Raphael
core
Genome‐Wide In Silico Analysis of the Type VI Secretion System (T6SS) Within the Morganella Genus
MicrobiologyOpen, Volume 15, Issue 3, June 2026.▪ Species‐specific T6SS patterns among Morganella genus (M. morganii and M. sibonii). ▪ Only one‐third of M. morganii isolates haboured a T6SS. ▪ All M. sibonii possess four T6SS clusters. ▪ M. sibonii exhibited a wide diversity of effectors compared to M. morganii.
Mathilde Duque +4 more
wiley +1 more source
Accuracy and efficiency define Bxb1 integrase as the best of fifteen candidate serine recombinases for the integration of DNA into the human genome [PDF]
, 2013 Background: Phage-encoded serine integrases, such as φC31 integrase, are widely used for genome engineering. Fifteen such integrases have been described but their utility for genome engineering has not been compared in uniform assays.
Smith, Maggie +17 more
core +1 more source
Frontiers in Microbiology, 2020 It is well known that bacteriophages play crucial roles in many aspects, such as controlling the number and the diversity of bacteria and participating in horizontal gene transfer, which is a key process in the evolution of bacteria. However, so far, the
Xinyan Yu +5 more
doaj +1 more source
MicrobiologyOpen, Volume 15, Issue 3, June 2026.Wastewater from urban and rural areas was analyzed to investigate antimicrobial‐resistant bacteria and resistance genes. ESBL‐Escherichia coli and genes coding for clinically relevant resistances, namely, those to macrolides, carbapenems, and vancomycin, were higher in urban than in rural areas.
Maya Petricciuolo +7 more
wiley +1 more source