Results 71 to 80 of about 5,999 (124)
Functional significance of SRJ domain mutations in CITED2.
PLoS ONE, 2012 CITED2 is a transcriptional co-activator with 3 conserved domains shared with other CITED family members and a unique Serine-Glycine Rich Junction (SRJ) that is highly conserved in placental mammals.
Chiann-mun Chen +10 more
doaj +1 more source
Advanced Science, Volume 12, Issue 41, November 6, 2025.This figure is a candidate for the cover image. It shows a whole‐mount fluorescent image of lymphatic vessels (red) in the heart of an adult Cdh5‐Dre; Prox1‐RSR‐CreER; Rosa26‐tdT mouse. Image courtesy of Ximeng Han. Abstract Cell fate determination is a fundamental process in multicellular development.
Hui Chen +3 more
wiley +1 more source
Advanced Science, Volume 12, Issue 42, November 13, 2025.Current herpesvirus treatments targeting the viral DNA polymerase are limited by toxicities and drug resistance. Novel compounds inhibiting the nuclease activity of the herpes simplex virus 1 (HSV‐1) terminase complex, required for viral genome packaging, have been identified.
Sabina Andreu +12 more
wiley +1 more source
Multi-target QSAR modelling in the analysis and design of HIV-HCV co-inhibitors: an in-silico study
BMC Bioinformatics, 2011 Background HIV and HCV infections have become the leading global public-health threats. Even more remarkable, HIV-HCV co-infection is rapidly emerging as a major cause of morbidity and mortality throughout the world, due to the common rapid mutation ...
Liu Qi +5 more
doaj +1 more source
Multipart DNA Assembly Using Site-Specific Recombinases from the Large Serine Integrase Family [PDF]
, 2017 Assembling multiple DNA fragments into functional plasmids is an important and often rate-limiting step in engineering new functions in living systems. Bacteriophage integrases are enzymes that carry out efficient recombination reactions between short, defined DNA sequences known as att sites.
Olorunniji, FJ +5 more
openaire +2 more sources
Organoid Models to Study Human Infectious Diseases
Cell Proliferation, Volume 58, Issue 11, November 2025.Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu +4 more
wiley +1 more source
BMC Microbiology, 2010 Background Vibrio Pathogenicity Island-2 (VPI-2) is a 57 kb region present in choleragenic V. cholerae isolates that is required for growth on sialic acid as a sole carbon source. V.
Napolitano Michael G +2 more
doaj +1 more source
Structural basis of directionality control in large serine integrases
AbstractLarge serine integrases (LSIs) catalyze unidirectional site-specific DNA recombination reactions, yet those reactions are reversed by the presence of a cognate recombination directionality factor (RDF). Mechanistic understanding of directionality control has been hampered by a lack of structural information.
Shin H +5 more
europepmc +2 more sources
The Plant Journal, Volume 124, Issue 4, November 2025.Significance Statement A transposable element (TE) enhances the expression of the cysteine‐rich receptor‐like kinase gene CRK8 in Arabidopsis thaliana, thereby reducing susceptibility to the fungal pathogen Sclerotinia sclerotiorum, but reducing tolerance to salt. Considering the widespread presence/absence polymorphism of this TE in the A.
Joris Macquet +4 more
wiley +1 more source
Control of the Serine Integrase Reaction: Roles of the Coiled-Coil and Helix E Regions in DNA Site Synapsis and Recombination. [PDF]
J Bacteriol, 2021 Mandali S, Johnson RC.
europepmc +1 more source