Results 81 to 90 of about 5,999 (124)

Isolation and characterization of the new Streptomyces phages Kamino, Geonosis, Abafar, and Scarif infecting a broad range of host species

Microbiology Spectrum
Streptomyces, a multifaceted genus of soil-dwelling bacteria belonging to the phylum Actinomycetota, features intricate phage-host interactions shaped by its complex life cycle and the synthesis of a diverse array of specialized metabolites.
Bente Rackow, Clara Rolland, Isabelle Mohnen, Johannes Wittmann, Mathias Müsken, Jörg Overmann, Julia Frunzke   +6 more
doaj   +1 more source

A bipartite thermodynamic-kinetic contribution by an activating mutation to RDF-independent excision by a phage serine integrase. [PDF]

Nucleic Acids Res, 2020
Fan HF, Su BY, Ma CH, Rowley PA, Jayaram M.   +4 more
europepmc   +1 more source

Serine Integrase Structure and Function

The FASEB Journal, 2011
Gregory D Van Duyne, Karen Rutherford, Kushol Gupta   +2 more
openaire   +1 more source

Large Serine Integrase Off-target Discovery and Validation for Therapeutic Genome Editing

SUMMARYWhile numerous technologies for the characterization of potential off-target editing by CRISPR/Cas9 have been described, the development of new technologies and analytical methods for off-target recombination by Large Serine Integrases (LSIs) are required to advance the application of LSIs for therapeutic gene integration.
Dane Z. Hazelbaker, Japan B. Mehta, Connor McGinnis, Didac Santesmasses, Anne M. Bara, Xiaoyu Liang, Thomas Biondi, Tim Fennell, Nils Homer, Brett Estes, Jenny Xie, Davood Norouzi, Kaivalya Molugu, Ravindra Amunugama, Chong Luo, Parth Amin, Xiarong Shi, Jesse Cochrane, Sandeep Kumar, Jie Wang, Matthew H. Bakalar, Jonathan D. Finn, Daniel J. O’Connell   +22 more
openaire   +1 more source

Control of Recombination Directionality by the Listeria Phage A118 Protein Gp44 and the Coiled-Coil Motif of Its Serine Integrase. [PDF]

J Bacteriol, 2017
Mandali S, Gupta K, Dawson AR, Van Duyne GD, Johnson RC.   +4 more
europepmc   +1 more source

Highly enhanced transgene integration in human pluripotent stem cells by serine integrase BxbI

SummaryGenome engineering and especially integration of large DNA payloads in human pluripotent stem cells (hPSC) remains challenging largely due to the sensitive nature of hPSCs. Site specific recombinases such as the serine integrase Bxb1 have been utilised successfully to target hPSC, however the targeting efficiencies remain low.
Matias I. Autio, Arnaud Perrin
openaire   +1 more source

Integrase-On-Demand: bioprospecting integrases for targeted genomic insertion of genetic cargo. [PDF]

Nucleic Acids Res
McClain HM, Lowrey LC, Quinto LB, Torrance EL, Gagliano TR, Isaacs FJ, Schoeniger JS, Williams KP, Mageeney CM.   +8 more
europepmc   +1 more source

Gene-sized editing for the therapy of genetic diseases. [PDF]

Funct Integr Genomics
Padureanu T, Cocoș R, Matache IM, Bucur O.   +3 more
europepmc   +1 more source

Genome Sequences of Cluster A Mycobacteriophages Dorothea and LappelDuVide, Isolated on <i>Mycobacterium smegmatis</i> mc ² 155. [PDF]

MicroPubl Biol
Pasterczyk N, Wilson C, Broker Z, Chobor A, Daughtry D, Dibor O, John A, Kandru S, Kodirova M, Mulligan C, Owate C, Pistone O, Smith S, Teitelman S, Victor S, Oganovich P, Hult M, Hooper R, Novak E, Mariaca S, Graham L, Mensah S, Kenna M, Ware V.   +23 more
europepmc   +1 more source

Introducing Two New Bacteriophages Isolated Using <i>Arthrobacter globiformis</i> : BlueShadow and Schaffner. [PDF]

MicroPubl Biol
Dojs M, Fleischacker C, Brekken C, Emineth E.   +3 more
europepmc   +1 more source