Advanced Science, EarlyView.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Extracellular: Plasma Membrane Proteases – Serine Proteases
, 2016 Membrane-anchored serine proteases are a group of extracellular serine proteases tethered directly to plasma membranes, via a C-terminal glycosylphosphatidylinositol linkage (GPI-anchored), a C-terminal transmembrane domain (Type I), or an N-terminal transmembrane domain (Type II).
Antalis, T.M., Buzza, M.S.
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Ultrastructural Analysis of Sporulation in a Conditional Serine Protease Mutant of Bacillus subtilis [PDF]
, 1972 Leatrice Y. Santo +2 more
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Post‐Translational Modifications in Cilia and Ciliopathies
Advanced Science, EarlyView.This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley +1 more source
Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors
Blood Advances, 2018 : Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics.
Alexey Dementiev +6 more
doaj
Advanced Science, EarlyView.This study revealed that oncogene Collaborator of ARF (CARF) is closely related to B‐cell lymphoma tumorigenesis, and shares a conserved mechanism regulating protein stability with Arabidopsis Kip‐Related Protein6 (KRP6) through casein kinase 1‐mediated phosphorylation. Reduced phosphorylation led to the enhanced protein stability of CARF, resulting in
Li Qu +7 more
wiley +1 more source
Interplay of Staphylococcal and Host Proteases Promotes Skin Barrier Disruption in Netherton Syndrome. [PDF]
, 2020 Netherton syndrome (NS) is a monogenic skin disease resulting from loss of function of lymphoepithelial Kazal-type-related protease inhibitor (LEKTI-1).
Butcher, Anna M +12 more
core
Lipopolysaccharide‐sensitive serine‐protease zymogen (factor C) of horseshoe crab hemocytes. Identification and alignment of proteolytic fragments produced during the activation show that it is a novel type of serine protease [PDF]
, 1987 Fuminori Tokunaga +6 more
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Advanced Science, EarlyView.GbSER02 with a single base change (SNP517G) encodes normal serpin protein and interacts with transcription factor VOZ1 to alleviate the repression of VOZ1 on GA3ox1 and promote GA3 biosynthesis. Further, GA3 induces the expression of cell wall loosening‐related genes and decreases flavonoid content, ultimately facilitating fiber cell elongation in ...
Hao Jia +12 more
wiley +1 more source
Requirement for glucose during production of extracellular serine protease by cultures ofBacillus licheniformis [PDF]
, 1981 G.W. Hanlon, Norman Hodges
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