Neutrophil serine proteases in antibacterial defense. [PDF]
Current Opinion in Microbiology, 2015 Neutrophil serine proteases (NSPs) are critical for the effective functioning of neutrophils and greatly contribute to immune protection against bacterial infections. Thanks to their broad substrate specificity, these chymotrypsin-like proteases trigger multiple reactions that are detrimental to bacterial survival such as direct bacterial killing ...
D. Stapels +2 more
semanticscholar +4 more sources
The Versatility of Serine Proteases from Brazilian Bothrops Venom: Their Roles in Snakebites and Drug Discovery [PDF]
BiomoleculesSerine proteases are multifunctional and versatile venom components found in viper snakes, including the Bothrops species, a widely distributed genus notorious for causing the highest number of snakebites across Latin America. These enzymes, representing
Marcela Romanazzi +12 more
doaj +2 more sources
Modeling and structural analysis of PA clan serine proteases
BMC Research Notes, 2012 Background Serine proteases account for over a third of all known proteolytic enzymes; they are involved in a variety of physiological processes and are classified into clans sharing structural homology. The PA clan of endopeptidases is the most abundant
Laskar Aparna +3 more
doaj +2 more sources
Serine proteases, serine protease inhibitors, and protease-activated receptors: Roles in synaptic function and behavior [PDF]
Brain Research, 2011 Serine proteases, serine protease inhibitors, and protease-activated receptors have been intensively investigated in the periphery and their roles in a wide range of processes-coagulation, inflammation, and digestion, for example-have been well characterized (see Coughlin, 2000; Macfarlane et al., 2001; Molinari et al., 2003; Wang et al., 2008; Di Cera,
Antoine G. Almonte, J. Sweatt
semanticscholar +4 more sources
Exploring the Diversity and Function of Serine Proteases in Toxicofera Reptile Venoms: A Comprehensive Overview [PDF]
ToxinsToxicofera reptile venoms are composed of several toxins, including serine proteases. These proteases are glycosylated enzymes that affect the prey’s hemostatic system. Their actions extend across the coagulation cascade, the kallikrein–kinin system, and
Julia F. D. Vidal +7 more
doaj +2 more sources
Airborne indoor allergen serine proteases and their contribution to sensitisation and activation of innate immunity in allergic airway disease [PDF]
European Respiratory ReviewCommon airborne allergens (pollen, animal dander and those from fungi and insects) are the main triggers of type I allergic disorder in the respiratory system and are associated with allergic rhinitis, allergic asthma, as well as immunoglobulin E (IgE ...
Xuan Ouyang +3 more
doaj +2 more sources
Protein targets of inflammatory serine proteases and cardiovascular disease
Journal of Inflammation, 2010 Serine proteases are a key component of the inflammatory response as they are discharged from activated leukocytes and mast cells or generated through the coagulation cascade.
Sharony Ram +5 more
doaj +2 more sources
Antibodies to Serine Proteases in the Antiphospholipid Syndrome [PDF]
Current Rheumatology Reports, 2010 It is generally accepted that the major autoantigen for antiphospholipid antibodies (aPL) in the antiphospholipid syndrome (APS) is β2-glycoprotein I (β2GPI). However, a recent study has revealed that some aPL bind to certain conformational epitope(s) on
Pojen P. Chen, I. Giles
semanticscholar +5 more sources
Discovery of Leishmania Druggable Serine Proteases by Activity-Based Protein Profiling [PDF]
Frontiers in Pharmacology, 2022 Leishmaniasis are a group of diseases caused by parasitic protozoa of the genus Leishmania. Current treatments are limited by difficult administration, high cost, poor efficacy, toxicity, and growing resistance. New agents, with new mechanisms of action,
Exequiel O. J. Porta +4 more
doaj +2 more sources
Design, synthesis, and evaluation of Bothrops venom serine protease peptidic inhibitors [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2021 Background: In Central and South America, snakebite envenomation is mainly caused by Bothrops spp. snakes, whose venoms feature significant biochemical richness, including serine proteases.
Gloria Maria da Silva +8 more
doaj +1 more source