Results 11 to 20 of about 183,910 (327)
Functional analysis of a missense mutation in the serine protease inhibitor SPINT2 associated with congenital sodium diarrhea. [PDF]
PLoS ONE, 2014 Membrane-bound serine proteases play important roles in different biological processes. Their regulation by endogenous inhibitors is poorly understood.
Nicolas Faller +2 more
doaj +6 more sources
Extracellular Pneumococcal Serine Proteases Affect Nasopharyngeal Colonization
Frontiers in Cellular and Infection Microbiology, 2021 Streptococcus pneumoniae has evolved versatile strategies to colonize the nasopharynx of humans. Colonization is facilitated by direct interactions with host cell receptors or via binding to components of the extracellular matrix.
Murtadha Q. Ali +7 more
doaj +1 more source
European Journal of Entomology, 2023 Rhyzopertha dominica is a pest that uses trypsin-like serine protease enzymes to hydrolyse the proteins in the cereal grains on which it feeds. The present study reveals for the first time that that there are both glycosylated and non-glycosylated serine
Fernanda S. ZAVALA-IBARRA +9 more
doaj +1 more source
Microbiology Spectrum, 2023 Serine proteases are a group of important hydrolytic enzymes that play vital roles in various cellular processes in fungi. In this study, the S8 serine protease-encoding gene CrKP43 was identified in the highly efficient Clonostachys chloroleuca 67–1 ...
Binna Lv +4 more
doaj +1 more source
Activity-Based Probes to Utilize the Proteolytic Activity of Cathepsin G in Biological Samples
Frontiers in Chemistry, 2021 Neutrophils, migrating to the site of infection, are able to release serine proteases after being activated. These serine proteases comprise cathepsin G (CatG), neutrophil elastase protease 3 (PR3), and neutrophil serine protease 4 (NSP4). A disadvantage
Timo Burster +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Several serine proteases have been linked to autoimmune disorders and tumour initiation although the mechanisms are not fully understood. Activation of the kynurenine pathway enzyme indoleamine-2,3-dioxygenase (IDO1) modulates cellular activity in the ...
Felix I. L. Clanchy +6 more
doaj +1 more source
Neurobiology of Disease, 2014 Although tissue plasminogen activator (tPA) is known to promote neuronal remodeling in the CNS, no mechanism of how this plastic function takes place has been reported so far.
Sighild Lemarchant +17 more
doaj +1 more source
IUBMB Life, 2009 AbstractOver one third of all known proteolytic enzymes are serine proteases. Among these, the trypsins underwent the most predominant genetic expansion yielding the enzymes responsible for digestion, blood coagulation, fibrinolysis, development, fertilization, apoptosis, and immunity.
openaire +3 more sources
Protease inhibitors targeting coronavirus and filovirus entry. [PDF]
, 2015 In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases.
Agudelo, Juliet +10 more
core +1 more source
SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties. [PDF]
, 2018 BackgroundSerine proteases are important virulence factors for many pathogens. Recently, we discovered a group of trypsin-like serine proteases with domain organization unique to flatworm parasites and containing a thrombospondin type 1 repeat (TSR-1 ...
Caffrey, Conor R +13 more
core +9 more sources