Results 51 to 60 of about 60,901 (333)

Dietary regulation of serine proteinases that are resistant to serine proteinase inhibitors

Journal of Insect Physiology, 1997
Ingestion of Kunitz soybean trypsin inhibitor (STI) by larval Helicoverpa zea, Agrotis ipsilon, and Trichoplusia ni extended the retention time of food in the digestive tract and increased the level of activity of proteolytic enzymes that were not susceptible to inhibition by STI.
openaire   +3 more sources

The Search for Natural and Synthetic Inhibitors That Would Complement Antivenoms as Therapeutics for Snakebite Envenoming

Toxins, 2021
A global strategy, under the coordination of the World Health Organization, is being unfolded to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure safe and effective treatments.
José María Gutiérrez, Laura-Oana Albulescu, Rachel H. Clare, Nicholas R. Casewell, Tarek Mohamed Abd El-Aziz, Teresa Escalante, Alexandra Rucavado   +6 more
doaj   +1 more source

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]

, 1989
Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY, Damsky, CH, Fisher, SJ, Grahl, K, Hartman, L, Tarpey, J, Zhang, GY, Zhang, L   +7 more
core   +3 more sources

Inibidores de proteases de hospedeiros nativos e exóticos e sua ação em intestinos de lagartas de Thyrinteina leucoceraea Proteinase inhibitors of novel and native host plants and their action in midgut of Thyrinteina leucoceraea caterpillars

Revista Árvore, 2008
Os insetos podem causar perdas consideráveis aos seus hospedeiros, entretanto alguns deles habitam em plantas sem causar-lhes danos. Por exemplo, Thyrinteina leucoceraea, herbívoro da entomofauna brasileira, pode ser encontrado na goiabeira, hospedeiro ...
Jeanne Scardini Marinho, Maria Goreti Almeida Oliveira, Raul Narciso Carvalho Guedes, Angelo Pallini, Claudinei Lima Oliveira   +4 more
doaj   +1 more source

Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick. [PDF]

PLoS ONE, 2008
Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of farm ...
Sandra Macedo-Ribeiro, Carla Almeida, Bárbara M Calisto, Thomas Friedrich, Reinhard Mentele, Jörg Stürzebecher, Pablo Fuentes-Prior, Pedro José Barbosa Pereira   +7 more
doaj   +1 more source

Degradation of human kininogens with the release of kinin peptides by extracellular proteinases of Candida spp. [PDF]

, 2010
The secretion of proteolytic enzymes by pathogenic microorganisms is one of the most successful strategies used by pathogens to colonize and infect the host organism.
Ben Nasr A., Ben Nasr A., Bergmann S., Boskey E.R., Colman R.W., De Bernardis F., Frick I.M., Imamura T., Kaminishi H., Karkowska-Kuleta J., Koelsch G., Maeda H., Maruo K., Matsudaira P., Molla A., Tapper H., White T.C.   +16 more
core   +1 more source

Purification and Characterization of a Novel Kazal-Type Trypsin Inhibitor from the Leech of Hirudinaria manillensis

Toxins, 2016
Kazal-type serine proteinase inhibitors are found in a large number of living organisms and play crucial roles in various biological and physiological processes.
Yanmei Lai, Bowen Li, Weihui Liu, Gan Wang, Canwei Du, Rose Ombati, Ren Lai, Chengbo Long, Hongyuan Li   +8 more
doaj   +1 more source

Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation

FEBS Letters, EarlyView.
The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt, Marcus S. Münchhoff, Jacqueline Krohn, Philip M. Palarz, Manuel H. Taft, Johannes N. Greve, Nataliya Di Donato, Falk F. R. Buettner, Dietmar J. Manstein   +8 more
wiley   +1 more source

Processing of Neutrophil α-Defensins Does Not Rely on Serine Proteases In Vivo. [PDF]

PLoS ONE, 2015
The α-defensins, human neutrophil peptides (HNPs) are the predominant antimicrobial peptides of neutrophil granules. They are synthesized in promyelocytes and myelocytes as proHNPs, but only processed in promyelocytes and stored as mature HNPs in ...
Andreas Glenthøj, Katrin Nickles, Jack Cowland, Niels Borregaard   +3 more
doaj   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source