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Serotonin syndrome: a clinical review of current controversies [PDF]

Journal of Integrative Neuroscience, 2020
Serotonin syndrome is a state of increased central and peripheral serotonin (5-hydroxytryptamine) activity. Unless recognized and treated early, serotonin syndrome can lead to seizures, shock and death.
Ursula Werneke, Petra Truedson-Martiniussen, Henrik Wikström, Michael Ott   +3 more
doaj   +1 more source

Plasma Serotonin and Cardiovascular Outcomes in Chronic Kidney Disease

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Platelet‐poor plasma serotonin levels are associated with adverse cardiovascular outcomes. Although plasma serotonin levels increase in chronic kidney disease, the cardiovascular implications remain unknown.
Daniel Edmonston, Tamara Isakova, Myles Wolf   +2 more
doaj   +1 more source

Targeting SERT promotes tryptophan metabolism: mechanisms and implications in colon cancer treatment

Journal of Experimental & Clinical Cancer Research, 2021
Background Serotonin signaling has been associated with tumorigenesis and tumor progression. Targeting the serotonin transporter to block serotonin cellular uptake confers antineoplastic effects in various tumors, including colon cancer.
Di Ye, Huanji Xu, Hongwei Xia, Chenliang Zhang, Qiulin Tang, Feng Bi   +5 more
doaj   +1 more source

DNA methylation of the serotonin transporter gene in peripheral cells and stress-related changes in hippocampal volume: a study in depressed patients and healthy controls. [PDF]

PLoS ONE, 2015
Serotonin plays an important role in the etiology of depression. Serotonin is also crucial for brain development. For instance, animal studies have demonstrated that early disruptions in the serotonin system affect brain development and emotion ...
Linda Booij, Moshe Szyf, Angela Carballedo, Eva-Maria Frey, Derek Morris, Sergiy Dymov, Farida Vaisheva, Victoria Ly, Ciara Fahey, James Meaney, Michael Gill, Thomas Frodl   +11 more
doaj   +1 more source

Monoamine Oxidase A Contributes to Serotonin—But Not Norepinephrine-Dependent Damage of Rat Ventricular Myocytes

Biomolecules, 2023
Serotonin effects on cardiac hypertrophy, senescence, and failure are dependent either on activation of specific receptors or serotonin uptake and serotonin degradation by monoamine oxidases (MAOs).
Jonas Knittel, Nadja Itani, Rolf Schreckenberg, Jacqueline Heger, Susanne Rohrbach, Rainer Schulz, Klaus-Dieter Schlüter   +6 more
doaj   +1 more source

The Effects of Serotonin in Immune Cells

Frontiers in Cardiovascular Medicine, 2017
Serotonin [5-hydroxytryptamine (5-HT)] plays an important role in many organs as a peripheral hormone. Most of the body’s serotonin is circulating in the bloodstream, transported by blood platelets and is released upon activation.
Nadine Herr, Christoph Bode, Daniel Duerschmied   +2 more
doaj   +1 more source

Telotristat ethyl reverses myxomatous changes in mice mitral valves

Frontiers in Cardiovascular Medicine, 2022
RationaleMyxomatous mitral valve degeneration is a common pathological manifestation of mitral valve regurgitation, with or without valvular prolapse.
Xinmei Wang, Danielle Kuban-Johnston, Pablo Lapuerta, Carla M. R. Lacerda   +3 more
doaj   +1 more source

Serotonin reuptake inhibitors and cardiovascular disease [PDF]

, 2005
Selective serotonin re-uptake inhibiting drugs (SSRIs) are widely used for endogenous depression. In addition to depleting the nerve terminals of serotonin they also lower blood platelet serotonin levels.
Belcher, P.R., Drake-Holland, A.J., Noble, M.   +2 more
core   +1 more source

Glycogen Synthase Kinase-3 is an intermediate modulator of serotonin neurotransmission

Frontiers in Molecular Neuroscience, 2011
Serotonin is a neurotransmitter with broad functions in brain development, neuronal activity, and behaviors; and serotonin is the prominent drug target in several major neuropsychiatric diseases.
Xiaohua eLi, Abigail ePolter
doaj   +1 more source

Food Anticipatory Activity on Circadian Time Scales Is Not Dependent on Central Serotonin: Evidence From Tryptophan Hydroxylase-2 and Serotonin Transporter Knockout Mice

Frontiers in Molecular Neuroscience, 2020
A number of studies implicate biogenic amines in regulating circadian rhythms. In particular, dopamine and serotonin influence the entrainment of circadian rhythms to daily food availability.
Christian M. Gallardo, Camille S. Martin, Andrew D. Steele   +2 more
doaj   +1 more source