Results 121 to 130 of about 479,925 (360)
Angewandte Chemie, EarlyView.Short amyloid peptides can act as efficient catalysts of neurotransmitter degradation, and libraries of short peptides can be used to identify core fragments present in larger proteins that might be linked to neurodegenerative diseases. Abstract We have shown that de novo designed peptides self‐assemble in the presence of copper to create ...
Inhye Kim +5 more
wiley +1 more source
Preclinical discovery of duloxetine for the treatment of depression [PDF]
, 2012 Introduction: Affective disorders, including major depressive disorder (MDD), are among the most severely disabling mental disorders, and in many cases areIntroduction: Affective disorders, including major depressive disorder (MDD), are among the most ...
Berrocoso Domínguez, Esther María +4 more
core +2 more sources
Parkinson's Disease, 2012 L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease.
Eunju Shin +2 more
doaj +1 more source
Honesty mediates the relationship between serotonin and reaction to unfairness [PDF]
, 2012 How does one deal with unfair behaviors? This subject has long been investigated by various disciplines including philosophy, psychology, economics, and biology. However, our reactions to unfairness differ from one individual to another.
C. F. Camerer +36 more
core +2 more sources
Serotonin, serotonin receptors and their actions in insects
Neurotransmitter, 2015 Serotonin is an ancient monoamine neurotransmitter, biochemically derived from tryptophan. It is most abundant in the gastrointestinal tract, but is also present throughout the rest of the body of animals and can even be found in plants and fungi. Serotonin is especially famous for its contributions to feelings of well-being and happiness.
Vleugels, Rut +2 more
openaire +2 more sources
Dissimilar Reactions and Enzymes for Psilocybin Biosynthesis in Inocybe and Psilocybe Mushrooms
Angewandte Chemie International Edition, EarlyView.Mushrooms have learned twice independently how to make the iconic magic mushroom natural product psilocybin. This article introduces the enzymes of the second pathway, found in a fiber cap mushroom. Curiously, the two pathways do not share any reaction, nor do the enzymes show a close relationship, but both pathways proceed via 4‐hydroxytryptamine as a
Tim Schäfer +3 more
wiley +1 more source
The synergistic effect of anticholinergic burden and depression on fall risk in older persons
British Journal of Clinical Pharmacology, EarlyView.Aims Both anticholinergic burden (ACB) and depression are known to increase fall risk in older persons, next to increasing morbidity and mortality. However, the effect of depression on fall risk associated with ACB is unclear. This is relevant because several antidepressants have anticholinergic effects to some extent.
Raymond Salet +7 more
wiley +1 more source
Relationship of Platelet Serotonin to Disturbances of Clotting and Hemostasis [PDF]
, 1957 Murray Weiner, Sidney Udenfriend
openalex +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Analgesic medicines are an important component of pain management, with different medicines carrying different risks and benefits. The aim of this study was to examine trends in analgesic prescribing in Ireland and England between 2014 and 2022. Methods Monthly data on medicines prescribed and dispensed in primary care were used. For Ireland, data
Molly Mattsson +8 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims We estimate trends in severe drug–drug interaction (DDI) prevalence and examine longitudinal associations between DDI exposure and health outcomes (emergency department [ED] visits, quality‐of‐life [QoL] and functional decline) over approximately 10‐years in the older community‐dwelling population in Ireland.
John E. Hughes +2 more
wiley +1 more source