Results 121 to 130 of about 234,379 (321)

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

open access: yesBMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu   +7 more
wiley   +1 more source

Anti‐inflammatory and Gastroprotective Effects of the Chamaerops humilis L. (DOUM) Fruit Aqueous Extract in Experimental Models of Edema and Gastric Ulcer

open access: yesChemistry &Biodiversity, EarlyView.
ABSTRACT Chronic inflammation can lead to various diseases, including gastric ulcers, highlighting the need for effective therapeutic strategies. The traditional use of Chamaerops humilis in Moroccan folk medicine for treating gastrointestinal disorders underscores its potential as a valuable natural remedy.
Yasmina Jaouhari   +12 more
wiley   +1 more source

New insights into glioma frequency maps: From genetic and transcriptomic correlate to survival prediction

open access: yesInternational Journal of Cancer, Volume 152, Issue 5, Page 998-1012, 1 March 2023., 2023
What's new? The spatial distribution of glioma is nonrandom. However, whether pathological grade influences glioma distribution across the brain remains unclear. Here, the authors built a population‐based frequency map for 396 patients with glioblastoma multiforme and 190 patients with lower‐grade glioma, revealing their distinct topographic ...
Hongbo Bao   +10 more
wiley   +1 more source

Prediction of 5-hydroxytryptamine Transporter Inhibitor based on Machine Learning [PDF]

open access: yesarXiv, 2019
In patients with depression, the use of 5-HT reuptake inhibitors can improve the condition. Topological fingerprints, ECFP4, and molecular descriptors were used. Some SERT and small molecules combined prediction models were established by using 5 machine learning methods. We selected the higher accuracy models(RF, SVM, LR) in five-fold cross-validation
arxiv  

Serotonergic modulators in Alzheimer's disease: a hope in the hopeless condition

open access: yesChemistry &Biodiversity, Accepted Article.
Alzheimer disease (AD) is the main cause of dementia worldwide. AD is a progressive brain neurodegenerative disease due to genetic and environmental factors that induce a progressive accumulation of intracellular hyperphosphorylated tau protein and extracellular amyloid protein (Aβ).
Ali I. Al-Gareeb   +5 more
wiley   +1 more source

Sentinel lymph node mapping in endometrial cancer: A comparison of main national and international guidelines

open access: yesInternational Journal of Gynecology &Obstetrics, Volume 160, Issue 1, Page 220-225, January 2023., 2023
Abstract Objectives To compare national and international guidelines regarding sentinel lymph node (SLN) mapping in endometrial cancer. Methods A descriptive comparative study of the National Comprehensive Cancer Network (NCCN), the Society of Gynecologic Oncology (SGO), the European Society of Gynecological Oncology (ESGO), the British Gynecological ...
Aharon Dick   +5 more
wiley   +1 more source

Role of Serotonin Neurons in L-DOPA- and Graft-Induced Dyskinesia in a Rat Model of Parkinson's Disease

open access: yesParkinson's Disease, 2012
L-DOPA, the most effective drug to treat motor symptoms of Parkinson's disease, causes abnormal involuntary movements, limiting its use in advanced stages of the disease.
Eunju Shin   +2 more
doaj   +1 more source

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