Results 101 to 110 of about 235,344 (293)
Investigation of a role for noradrenaline in the neurochemical and behavioural effects of an established and putative target for antianxiety/antidepressant drugs: a microdialysis and behavioural study in rats and NK1 receptor knockout mice. [PDF]
, 2005 The precise neurochemical effects of antidepressants that underlie their efficacy remain unclear. Many antidepressants modulate noradrenaline transmission in vivo.
Stewart, R.J.
core
Exploring new avenues: Psychedelic‐assisted therapy for young people
British Journal of Clinical Pharmacology, EarlyView.Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou +3 more
wiley +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask +6 more
wiley +1 more source
Pharmacological Monotherapy for Depressive Disorders: Current and Future—A Narrative Review
MedicinaObjective: To narratively review currently available antidepressants and future potential antidepressants as monotherapy for the treatment of depressive disorders.
Keming Gao +2 more
doaj +1 more source
, 2008 Although serotonin, serotonin uptake inhibitors and serotonin precursors (including tryptophan or 5- hydroxytryptophan) are known to have hypoglycemic action in rodents or human, it is not clear whether serotonin has hypoglycemic effect in streptozotocin-
紀宗呈;何宜錦;李水盛;鄭瑞棠;蘇銘嘉 +1 more
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, 2010 International audienceThis review focuses on new insights provided by gene-modified animals into the cardiovascular pharmacology of serotonin. During their development, mice mutant for tryptophan hydroxylase 1 and lacking peripheral serotonin, or mutant ...
Tarak Ayadi +9 more
core +1 more source
Environmental impact of antidepressants: Is a new prescription framework possible?
British Journal of Clinical Pharmacology, EarlyView.Aims Antidepressants such as venlafaxine and sertraline pose high risks to water ecosystems. As depressive disorders and other mental health conditions become increasingly prevalent worldwide, prescription and environmental presence of these pharmaceuticals continue to rise. This study explores the practical viability of a new framework for prescribing
Matilde Bianconi +5 more
wiley +1 more source
Reformulating a Pharmacophore for 5‑HT2A Serotonin Receptor Antagonists
, 2016 Several pharmacophore models have been proposed for 5-HT2A serotonin receptor antagonists. These typically consist of two aromatic/hydrophobic moieties separated by a given distance from each other, and from a basic amine.
Lia Baki (2883374) +13 more
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang +3 more
wiley +1 more source
Role of serotonin type 2 receptors in regulation of aldosterone production
, 1985 It is well recognized that serotonin stimulates aldosterone production by the adrenal glands. To investigate the possible roles of serotonin type 1 and 2 receptors in the regulation of aldosterone production, we examined the effects of cyproheptadine (a ...
M. Ishii +3 more
core +1 more source