Serotonin antagonists - Open Access .click

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O-Methylasparvenone, a nitrogen-free serotonin antagonist

Bioorganic & Medicinal Chemistry, 1997
O-Methylasparvenone (1) and asparvenone (2) were isolated from an Aspergillus parvulus Smith broth in a microbial screening for 5-HT2C ligands and found to be 5-HT2C antagonists. They represent the first nitrogen-free serotonin ligands. The absolute configuration of 1 was determined to be S by X-ray analysis of the corresponding Mosher-ester.
M, Bös +5 more
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Influence of serotonin antagonists on bulbospinal systems

Brain Research, 1973
Abstract We attempted to elucidate the function of the serotonin-containing bulbospinal neurons by directly stimulating the raphe nucleus of unanesthetized decerebrates cats. Such stimuli evoked both a dorsal and a ventral root potential, and produced a complex time-dependent facilitation and inhibition of segmentally evoked monosynaptic reflexes ...
H K, Proudfit, E G, Anderson
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Serotonin, Serotonergic Antagonists, and Hypertension

1986
Whether the increased total systemic vascular resistance characteristic of chronic hypertension is a primary event or secondary to increased cardiac output is still debated. Whatever the initiating cause, the increased resistance must result from the narrowing of the small arteries and arterioles (Fig. 1).
P. M. Vanhoutte, R. F. J. Shepherd
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Ketanserin, A Serotonin Antagonist