Results 31 to 40 of about 40,842 (165)

Cholestatic Pruritus in Children: Conventional Therapies and Beyond

Biology, 2023
Pruritus in the setting of cholestatic liver disease is difficult to treat and occurs in patients ranging in age from infancy to adulthood. Likely multifactorial in etiology, this symptom often involves multimodal therapy targeting several pathways and ...
Minna Rodrigo, Xinzhong Dong, Daphne Chien, Wikrom Karnsakul   +3 more
doaj   +1 more source

5-Hydroxytryptamine Receptors and Tardive Dyskinesia in Schizophrenia

Frontiers in Molecular Neuroscience, 2020
BackgroundTardive dyskinesia (TD) is a common side effect of antipsychotic treatment. This movement disorder consists of orofacial and limb-truncal components.
Ivan V. Pozhidaev, Ivan V. Pozhidaev, Diana Z. Paderina, Diana Z. Paderina, Olga Yu. Fedorenko, Olga Yu. Fedorenko, Elena G. Kornetova, Elena G. Kornetova, Arkadiy V. Semke, Anton J. M. Loonen, Anton J. M. Loonen, Nikolay A. Bokhan, Nikolay A. Bokhan, Nikolay A. Bokhan, Bob Wilffert, Bob Wilffert, Svetlana A. Ivanova, Svetlana A. Ivanova, Svetlana A. Ivanova   +18 more
doaj   +1 more source

Is the combination of domperidone and metoclopramide increasing the risk of developing serotonin syndrome?: a case report [PDF]

Pediatric Emergency Medicine Journal
Metoclopramide and domperidone are dopamine antagonists that can cause an acute dystonic reaction. Metoclopramide is a rare but major contributor to serotonin syndrome, particularly when used with other serotonergic agents.
Abdullah Nasser Aldosari, Abdullah Alzahrani, Mohammed Alghamdi, Abdulaziz Alzahrani, Abdulraheem Alghamdi   +4 more
doaj   +1 more source

Antagonists of the serotonin receptor 5A target human breast tumor initiating cells

BMC Cancer, 2020
Background Breast tumor initiating cells (BTIC) are stem-like cells that initiate and sustain tumor growth, and drive disease recurrence. Identifying therapies targeting BTIC has been hindered due primarily to their scarcity in tumors.
William D. Gwynne, Mirza S. Shakeel, Adele Girgis-Gabardo, Kwang H. Kim, Emily Ford, Anna Dvorkin-Gheva, Craig Aarts, Methvin Isaac, Rima Al-awar, John A. Hassell   +9 more
doaj   +1 more source

Serotonin 5-HT7 Receptor Antagonists

Current Medicinal Chemistry-Central Nervous System Agents, 2004
The 5-HT7R is the most recent addition to the burgeoning family of serotonin receptors. Preliminary evidences suggest that it may be involved in depression, control of circadian rhythms, and relaxation in a variety of vascular smooth muscles, indicating the high potential of 5-HT7R ligands as new therapeutic drugs.
López Rodríguez, María L., Benhamú, Bellinda, Morcillo, M. José, Porras, Esther, Pardo, Leonardo, Lavandera Díaz, José Luis   +5 more
openaire   +2 more sources

Function and distribution of 5-HT2 receptors in the honeybee (Apis mellifera). [PDF]

PLoS ONE, 2013
BACKGROUND: Serotonin plays a pivotal role in regulating and modulating physiological and behavioral processes in both vertebrates and invertebrates. In the honeybee (Apis mellifera), serotonin has been implicated in division of labor, visual processing,
Markus Thamm, Daniel Rolke, Nadine Jordan, Sabine Balfanz, Christian Schiffer, Arnd Baumann, Wolfgang Blenau   +6 more
doaj   +1 more source

The effect of acute Lithium and AMI-193, a new 5HT2 antagonist, on Apomorphine-induced pecking in pigeon [PDF]

Acta Medica Iranica, 2002
Intramascular (IM) administration of apomorphine (a mixed D1/D2 dopamine receptors agonist 0.2-1.6 mg/kg) induced pecking, a stereotype behavior in pigeons in a dose- dependent manner. In this study the effect of lithium (Li+, 240 mg/kg, IM) and AMI-193 (
Bagheri T, Ejtemaei Mehr Sh, Shamshirgaran Sh   +2 more
doaj   +1 more source

Influence of the descending pain-inhibiting serotonergic pathway on the antihyperalgesic effect of gabapentin in neuropathic pain model rats

Neuroscience Research
Gabapentinoids are used worldwide as first-line agents for the treatment of neuropathic pain. Accumulating evidence indicates that one of the antihyperalgesic mechanisms of gabapentinoids is through activation of the noradrenergic pathway of the ...
Harue Yanagimura, Mika Sasaki, Hiroshi Baba, Yoshinori Kamiya   +3 more
doaj   +1 more source

Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

RUDN Journal of Medicine, 2011
This study is dedicated to investigation of serotoninergic structures that activate motility of the stomach. Experiments were performed on 94 Wistar rats under general anesthesia, mechanical ventilation, bilateral vagotomy and transection of both ...
V I Torshin, V M Smirnov, D S Sveshnikov, A V Kuchuk, I A Yurasova   +4 more
doaj  

Serotonin syndrome: An often-neglected medical emergency

Journal of Family and Community Medicine
Optimum serotonin level in the serotonergic synapses of the central nervous system (CNS) is related to mood, behavior, and sleep. Serotonin syndrome (SS) is a rare yet very dangerous adverse effect resulting from increased serotonin in CNS. The diagnosis
Ahmed Badar
doaj   +1 more source