Results 41 to 50 of about 40,842 (165)

Triptans and CGRP blockade – impact on the cranial vasculature

The Journal of Headache and Pain, 2017
The trigeminovascular system plays a key role in the pathophysiology of migraine. The activation of the trigeminovascular system causes release of various neurotransmitters and neuropeptides, including serotonin and calcitonin gene-related peptide (CGRP),
Silvia Benemei, Francesca Cortese, Alejandro Labastida-Ramírez, Francesca Marchese, Lanfranco Pellesi, Michele Romoli, Anne Luise Vollesen, Christian Lampl, Messoud Ashina, On behalf of the School of Advanced Studies of the European Headache Federation (EHF-SAS)   +9 more
doaj   +1 more source

Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome

Clinical and Experimental Gastroenterology, 2014
Ryohei Itagaki, Keiji Koda, Masato Yamazaki, Kiyohiko Shuto, Chihiro Kosugi, Atsushi Hirano, Hidehito Arimitsu, Risa Shiragami, Yukino Yoshimura, Masato Suzuki Department of Surgery, Teikyo University Chiba Medical Center, Anesaki, Ichihara, Chiba, Japan
Itagaki R, Koda K, Yamazaki M, Shuto K, Kosugi C, Hirano A, Arimitsu H, Shiragami R, Yoshimura Y, Suzuki M   +8 more
doaj  

Behavioral and neuropharmacological evidence that serotonin crosses the blood-brain barrier in Coturnix japonica (Galliformes; Aves)

Brazilian Journal of Biology
This study was carried out aiming to reach behavioral and neuropharmacological evidence of the permeability of the blood-brain barrier (BBB) to serotonin systemically administered in quails. Serotonin injected by a parenteral route (250-1000 µg.kg-1, sc)
PA. Polo, RO. Reis, PL. Cedraz-Mercez, HR. Cavalcante-Lima, EL. Olivares, MA. Medeiros, WS. Côrtes, LC. Reis   +7 more
doaj   +1 more source

5-HT3 and 5-HT4 antagonists inhibit peristaltic contractions in guinea-pig distal colon by mechanisms independent of endogenous 5-HT

Frontiers in Neuroscience, 2013
Recent studies have shown that endogenous serotonin is not required for colonic peristalsis in vitro, nor gastrointestinal (GI) transit in vivo. However, antagonists of 5-Hydroxytryptamine (5-HT) receptors can inhibit peristalsis and GI-transit in ...
Tiong Cheng Sia, Malcolm eWhiting, Melinda eKyloh, Sarah eNicholas, Simon J Brookes, John eOliver, Phil eDinning, David A Wattchow, Nick J Spencer   +8 more
doaj   +1 more source

5-HT3 receptor antagonists protect against pressure overload-induced cardiac hypertrophy in murine

Acta Pharmaceutica Sinica B, 2012
Activation of cardiac sympathetic afferent reflex results in the increase of sympathetic activity. Serotonin (5-HT) activates cardiac sympathetic afferent through stimulating 5-HT3 receptors, the aim of present study is to test whether 5-HT3 receptor ...
Rong Huo, Chang Chen, Yan Chen, Zhe Li, Yunlong Hou, Deli Dong   +5 more
doaj   +1 more source

Advances in migraine treatment - a review

Quality in Sport
Introduction Migraine is a heavily debilitating disease  that ranks second place in Global Burden Disease. It is estimated that around 1 billion of people suffer from it.
Katarzyna Słychan, Agata Frańczuk, Aleksandra Makłowicz, Angelika Szpulak, Ewelina Kopczyńska, Julia Głoskowska, Michalina Grzelka, Katarzyna Kuleta, Aleksandra Elżbieta Łęska, Paulina Kejna   +9 more
doaj   +1 more source

Serotonin Type 6 and 7 Receptors as a Novel Therapeutic Target for the Treatment of Schizophrenia

Neuropsychiatric Disease and Treatment, 2020
Etsay Weldekidan Tsegay,1 Desalegn Getnet Demise,1 Nigus Alemu Hailu,2 Zenawi Hagos Gufue3 1Department of Pharmacy, College of Medicine and Health Sciences, Adigrat University, Adigrat, Tigray, Ethiopia; 2Department of Biomedical Science, College of ...
Tsegay EW, Demise DG, Hailu NA, Gufue ZH
doaj  

Pharmacological Monotherapy for Depressive Disorders: Current and Future—A Narrative Review

Medicina
Objective: To narratively review currently available antidepressants and future potential antidepressants as monotherapy for the treatment of depressive disorders.
Keming Gao, Evrim Bayrak Oruc, Buket Koparal   +2 more
doaj   +1 more source

Serotonin Antagonist [PDF]

, 2020
openaire   +1 more source

Neurokinin 1/3 Receptor Antagonists for Vasomotor Symptoms in Women with Breast Cancer

healthbook TIMES. Oncology Hematology
Endocrine therapy remains a cornerstone treatment for patients with hormone receptor-positive breast cancer. However, its benefits are often undermined by treatment-related adverse events, including vasomotor symptoms (VMS) such as hot flashes and night ...
Michael Gnant, Marcus Vetter, Petra Stute   +2 more
doaj   +1 more source