Results 201 to 210 of about 198,301 (307)

HIF2A as a prognostic and clinical therapeutic target in ovarian clear cell carcinoma

International Journal of Cancer, EarlyView.
What's New? Ovarian clear cell carcinoma is highly associated with hypoxia. Hypoxia‐inducible factor 2A (HIF2A) is a key regulator of hypoxic responses, but its role in ovarian clear cell carcinoma remains unclear. This study demonstrated the unfavorable prognostic significance of HIF2A expression in ovarian clear cell carcinoma.
Mengxin Jiang, Ken Yamaguchi, Kohei Hamada, Yuko Hosoe, Yuka Mise, Sachiko Kitamura, Zhihong Liu, Hairong Wei, Zhenhai Gao, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Rin Mizuno, Taito Miyamoto, Junzo Hamanishi, Masaki Mandai   +15 more
wiley   +1 more source

Exploring the Potential of Coumarin Derivatives on Serotonin Receptors 5-HT_1A and 5HT_2A. [PDF]

Int J Mol Sci
Ostrowska K, Horosz G, Kruk K, Sieroń B, Leśniak A, Czartoryska Z, Bujalska-Zadrożny M, Milenkovic D, Trzaskowski B.   +8 more
europepmc   +1 more source

Modulation of Serotonin Receptors in Neurodevelopmental Disorders: Focus on 5-HT7 Receptor. [PDF]

Molecules, 2021
Lee J, Avramets D, Jeon B, Choo H.
europepmc   +1 more source

Effects from a single application of photobiomodulation on pain intensity from perineal trauma related to childbirth: A randomized controlled trial

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective To analyze the effects of a single photobiomodulation (PBM) application on perineal pain and healing in women in the immediate postpartum period. Methods Randomized controlled trial, double‐blind, two‐center, with 60 postpartum women with perineal trauma and pain scoring 4 or more on the Numeric Rating Scale (NRS).
Edna Jéssica Lima Gondim, Simony Lira Nascimento, Maria Victória Candida Gaitero, Ticiana Aparecida Alves Mira, Andrea Vasconcelos Gonçalves, Fernanda Garanhani Surita   +5 more
wiley   +1 more source

Zacopride stimulates 5-HT₄ serotonin receptors in the human atrium. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Neumann J, Hesse C, Hofmann B, Gergs U.
europepmc   +1 more source

Serotonin (5-HT1A) receptor; serotonin (5-HT3) receptor [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Mosapride stimulates human 5-HT₄-serotonin receptors in the heart. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Neumann J, Hesse C, Hofmann B, Gergs U.
europepmc   +1 more source

Host–microbiota interaction drives 5‐hydroxyindole‐3‐acetic acid production to promote linear growth in infant mice

iMetaOmics, EarlyView.
This study discovered that Lactiplantibacillus plantarum Hi188 promoted linear growth in postweaning mice. Transcriptomic analysis, untargeted metabolomics, and in vitro experiments showed that the elevated levels of 5‐hydroxyindole‐3‐acetic acid (5‐HIAA) activated the hepatic aryl hydrocarbon receptor (AhR) and subsequently promoted insulin‐like ...
Yongmei Yang, Jing Yang, Weiyao Zhang, Linghao Zhou, Chenxu Zhu, Xuguang Zhang, Yuejian Mao, Meiling Zhang   +7 more
wiley   +1 more source

Weizmannia coagulans XY2 Mitigates Copper Neurotoxicity via Gut–Brain Axis Modulation of Tryptophan Metabolism and Oxidative‐Inflammatory Crosstalk

iMetaOmics, EarlyView.
Copper interferes with tryptophan metabolism and 5‐HT levels by modulating intestinal flora. Intestinal barrier breakdown and inflammatory response trigger nerve damage under copper exposure. W. coagulans XY2 alleviates copper‐induced neurotoxicity by targeting a multi‐dimensional “tryptophan metabolism‐antioxidant defense‐gut‐brain axis” network.
Yufang Gao, Xiaodong Zheng, Fujie Yan
wiley   +1 more source