Results 211 to 220 of about 267,093 (291)

Psychotropic medication and the fetal brain

The Journal of Physiology, EarlyView.
Abstract figure legend Brain region changes linked to in‐utero psychotropic exposure. Abstract Medications known to cross the blood–brain barrier (psychotropic medications) are commonly prescribed to women during pregnancy, often for the management of mental illness.
Oliver Gale‐Grant, Tomoki Arichi
wiley   +1 more source

Serotonin transporter downregulation is associated with aortic stenosis, and early profibrotic remodeling is mitigated by pharmacological inhibition of HTR2B receptor. [PDF]

Front Cardiovasc Med
Levine D, Camillo C, Castillero E, Bektik E, Kosuri Y, Campbell A, Karcher C, Krieger A, Pei L, Peng T, Zeak N, Faridmoayer E, Oyama MA, Grau JB, Levy RJ, Ferrari G.   +15 more
europepmc   +1 more source

Physiological and anatomical determinants of placental drug transfer

The Journal of Physiology, EarlyView.
Abstract figure legend Fetal exposure to pharmaceuticals and their subsequent clearance back to the maternal circulation are governed by placental transfer. Passive diffusion down a maternal‐to‐fetal concentration gradient is the primary route of fetal drug exposure, with specific compounds undergoing transporter‐mediated transfer.
Rohan M. Lewis, Anandita Umapathy, Jane K. Cleal, Bram G. Sengers   +3 more
wiley   +1 more source

Differential susceptibility to prenatal stress exposure in serotonin transporter-deficient female mice-an epigenetic exploration. [PDF]

Front Neurosci
Weidner MT, Zöller JEM, Hamann CS, Schraut KG, Ali M, Lardenoije R, Eijssen L, Foerstner KU, Gorbunov N, Strekalova T, Domschke K, Schmitt-Böhrer AG, Lesch KP, Leibold NK, van den Hove DLA.   +14 more
europepmc   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Human <i>in vivo</i> assessment of ketamine binding of the serotonin transporter-follow up at a higher dose. [PDF]

Front Neurosci
Schlosser G, Murgaš M, Godbersen GM, Reichel S, Silberbauer L, Nics L, Winkler D, Stimpfl T, Hacker M, Kasper S, Rujescu D, Lanzenberger R, Spies M.   +12 more
europepmc   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

The Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière, Thomas Boulin, Maëlle Jospin, Alexandre Janin, Gilles Millat, Philippe Chevalier, Olga Andrini   +6 more
wiley   +1 more source

Cell membrane cholesterol affects serotonin transporter efflux due to altered transporter oligomerization. [PDF]

Mol Psychiatry
Rudin D, Luethi D, Niello M, Yang JW, Burger I, Sandtner W, Birner-Gruenberger R, Schütz GJ, Sitte HH.   +8 more
europepmc   +1 more source

Association between the serotonin transporter gene and affective disorder: the evidence so far [PDF]

, 1997
Harmar, Anthony J, Ogilvie, A D
core  

High‐altitude headache: Insights into pathophysiology and potential treatment implications

The Journal of Physiology, EarlyView.
Abstract figure legend High‐altitude headache occurs during prolonged exposure to low oxygen, such as during ascent to high altitude. Several risk factors increase its likelihood, with the degree of hypoxia, often driven by rapid ascent to greater altitudes, being the most prominent factor.
Marika Falla, Florian Frank, Giacomo Strapazzon, Justin Lawley   +3 more
wiley   +1 more source