Results 251 to 260 of about 267,093 (291)

Serotonin Transporters, Serotonin Release, and the Mechanism of Fenfluramine Neurotoxicity

Annals of the New York Academy of Sciences, 2000
AbstractAdministration ofd,l‐fenfluramine (FEN), or the more active isomerd‐fenfluramine (dFEN), causes long‐term depletion of forebrain serotonin (5‐HT) in animals. The mechanism underlying FEN‐induced 5‐HT depletion is not known, but appears to involve 5‐HT transporters (SERTs) in the brain. Some investigators have postulated that 5‐HT release evoked
M H, Baumann, M A, Ayestas, C M, Dersch, J S, Partilla, R B, Rothman   +4 more
openaire   +2 more sources

Organic cation transporter capable of transporting serotonin is up‐regulated in serotonin transporter‐deficient mice

Journal of Neuroscience Research, 2002
AbstractThe serotonin (5HT) transporter (5HTT) regulates serotonergic neurotransmission by mediating the reuptake of 5HT from the synaptic cleft. Although lacking the high affinity and selectivity of the 5HTT, the brain expresses a large number of other transporters, including the polyspecific organic cation transporters (OCTs).
A, Schmitt, R, Mössner, A, Gossmann, I G, Fischer, V, Gorboulev, D L, Murphy, H, Koepsell, K P, Lesch   +7 more
openaire   +2 more sources

Polymorphism of the Serotonin Transporter

American Journal of PharmacoGenomics, 2001
Selective serotonin reuptake inhibitors (SSRIs) are used to treat a number of psychiatric disorders related to mood and anxiety, and variations in the serotonin transporter (5-HTT) gene may be involved in a number of these. A polymorphic site in the promoter region is associated with differences in 5-HTT gene expression.
F E, Lotrich, B G, Pollock, R E, Ferrell
openaire   +2 more sources

Behavioural Genetics of the Serotonin Transporter

2011
The serotonin transporter is a key regulator of the bioavailability of serotonin and therefore any modulation in the expression or action of the transporter would be expected to have consequences on behaviour. The transporter has therefore become a target for pharmaceutical intervention in behavioural and mood disorders.
K, Haddley, V J, Bubb, G, Breen, U M, Parades-Esquivel, J P, Quinn   +4 more
openaire   +2 more sources

The serotonin transporter gene as a QTL for ADHD

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2005
AbstractMolecular studies of attention deficit hyperactivity disorder (ADHD) have identified susceptibility genes for the categorically diagnosed disorder using operational diagnostic criteria. Here, we take a QTL approach to mapping genes for ADHD using a composite continuous index of ADHD behavior in a large epidemiological sample.
Craig, I, Sham, P, Curran, S, Purcell, S, Asherson, P   +4 more
openaire   +4 more sources

Tegaserod Inhibits the Serotonin Transporter SERT

Digestion, 2007
<i>Background:</i> Tegaserod is a novel drug for the treatment of constipation-predominant irritable bowel syndrome. Tegaserod is thought to exert its prokinetic effect as a selective partial agonist of serotonin receptor type 4 (5-HT₄) receptors located in the enteric nervous system.
Ismair Manfred G., Kullak-Ublick Gerd A., Blakely Randy D., Fried Michael, Vavricka Stephan R.   +4 more
openaire   +3 more sources

The serotonin transporter and depression

Depression and Anxiety, 1998
M J, Owens, C B, Nemeroff
openaire   +2 more sources

Structure-Based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

Cell, 2023
Anubha Seth, Brian K. Shoichet, Gary Rudnick   +2 more
exaly  

Platelet serotonin transporter

1992
G, Rudnick, C J, Humphreys
openaire   +2 more sources

Serotonin transporter and behavioral traits

Psychiatry Research, 2018
Beuy, Joob, Viroj, Wiwanitkit
openaire   +2 more sources