Results 241 to 250 of about 267,093 (291)

Pharmacogenetics of the serotonin transporter

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2005
Response to psychopharmacologic drugs is genetically complex, results from an interplay of multiple genomic variations with environmental influences, and depends on the structure or functional expression of gene products, which are direct drug targets or indirectly modify the development and synaptic plasticity of neural networks critically involved in
Klaus Peter, Lesch, Lise, Gutknecht
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Seasonal Difference in Brain Serotonin Transporter Binding Predicts Symptom Severity in Patients With Seasonal Affective Disorder.

Brain, 2016
Cross-sectional neuroimaging studies in non-depressed individuals have demonstrated an inverse relationship between daylight minutes and cerebral serotonin transporter; this relationship is modified by serotonin-transporter-linked polymorphic region ...
Claus Svarer, Klaus Kähler Holst, William F. C. Baaré   +2 more
exaly   +2 more sources

Serotonin transporter and memory

Neuropharmacology, 2011
The serotonin transporter (SERT) has been associated to diverse functions and diseases, though seldom to memory. Therefore, we made an attempt to summarize and discuss the available publications implicating the involvement of the SERT in memory, amnesia and anti-amnesic effects.
Alfredo, Meneses, Georgina, Perez-Garcia, Teresa, Ponce-Lopez, Ruth, Tellez, Carlos, Castillo   +4 more
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Serotonin Transporter and Serotonin Receptors

2013
The nature of the primary defect responsible for triggering and maintaining pulmonary artery smooth muscle (PA-SMC) proliferation in pulmonary artery hypertension (PAH) is poorly understood but may be either an inherent characteristic of PA-SMCs or a secondary response to an external abnormality, such as upregulation of growth factors.
Serge, Adnot, Amal, Houssaini, Shariq, Abid, Elisabeth, Marcos, Valérie, Amsellem   +4 more
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Schizophrenia and the Serotonin Transporter Gene

Psychiatric Genetics, 1998
A case control study was conducted among cases with schizophrenia (DSM IV criteria) and screened adult controls from three cohorts. Bi-allelic polymorphisms in the promoter region of the serotonin transporter gene (5-HTT) were examined in conjunction with those of the serotonin 5-HT2a receptor (HTR2).
D, Rao, E G, Jönsson, S, Paus, R, Ganguli, M, Nöthen, V L, Nimgaonkar   +5 more
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Anatomy of the Serotonin Transporter

2019
Serotonin plays an important role in the regulation of various physiological functions, including mood, social and sexual behaviors, appetite, digestion, sleep, and memory. Therefore, the extracellular levels of serotonin must be finely controlled and regulated.
Beecher, Kate, Belmer, Arnauld, Bartlett, Selena E.   +2 more
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Genetic perspectives on the serotonin transporter

Brain Research Bulletin, 2001
The serotonin transporter (5-HTT) is most well known as the site of action of the serotonin reuptake inhibitors, which were initially developed as antidepressants, but now are the most widely used agents in the treatment of many additional neuropsychiatric and related disorders.
D L, Murphy, Q, Li, S, Engel, C, Wichems, A, Andrews, K P, Lesch, G, Uhl   +6 more
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Studies on the serotonin transporter in platelets

Experientia, 1988
[3H]-Imipramine and [3H]-paroxetine label with high affinity a recognition site which is associated with the serotonergic transporter in blood platelets. The pharmacological profile of [3H]-imipramine and [3H]-paroxetine binding is highly correlated with the potency of drugs to inhibit the uptake of serotonin.
S Z, Langer, A M, Galzin
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Serotonin and the serotonin transporter in the adrenal gland

The adrenal glands are key components of the mammalian endocrine system, helping maintain physiological homeostasis and the coordinated response to stress. Each adrenal gland has two morphologically and functionally distinct regions, the outer cortex and inner medulla.
Mary Beth, Bauer, Kevin P M, Currie
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6-Fluoro-serotonin as a substrate for the neuronal serotonin transporter

Journal of Neural Transmission, 1994
6-Fluoro-serotonin (6F-5-HT) was previously identified in the rat brain after peripheral administration of 6-fluoro-DL-tryptophan, a serotonin (5-HT) synthesis inhibitor. These present studies, performed with rat brain synaptosomes show that: i-neuronal 6F-5-HT uptake partly involved the 5-HT transporter since it was inhibited by clomipramine, a 5-HT ...
E, Chanut, J J, Bonnet, J H, Trouvin, M, Plat, J, Costentin, C, Jacquot   +5 more
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